Rodents / / Committee on Rodents, Institute of Laboratory Animal Resources, Commission on Life Sciences, National Research Council

• Record Nr.: UNINA9910970044203321
• Pubbl/distr/stampa: Washington, D.C., : National Academy Press, 1996
• ISBN: 9786610196050; 9780309176927; 0309176921; 9781280196058; 128019605X; 9780309585774; 0309585775; 9780585019949; 0585019940
• Edizione: [1st ed.]
• Descrizione fisica: 1 online resource (179 pages) : illustrations
• Collana: Laboratory animal management
• Disciplina: 619/.93
• Soggetti: Rodents as laboratory animals
• Lingua di pubblicazione: Inglese
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Note generali: Bibliographic Level Mode of Issuance: Monograph
• Nota di bibliografia: Includes bibliographical references and index.
• Nota di contenuto: Rodents -- Copyright -- Preface -- Contents -- 1 Laboratory Animals and Public Perspective -- REGULATORY ISSUES -- ETHICAL CONSIDERATIONS -- REFERENCES -- 2 Responsibilities of Animal Care and Use Committees -- PROGRAM OVERSIGHT -- PROTOCOL REVIEW -- PERSONNEL QUALIFICATIONS AND TRAINING -- OCCUPATIONAL HEALTH AND SAFETY -- USE OF HAZARDOUS AGENTS -- REFERENCES -- 3 Criteria for Selecting Experimental Animals -- SPECIES AND STOCKS -- Choosing a Species for Study -- Rodent Stocks -- Genetically Defined Stocks -- Nongenetically Defined Stocks -- STANDARDIZED NOMENCLATURE FOR RODENTS -- Inbred Strains -- Substrains -- Laboratory Codes -- F1 Hybrids -- Coisogenic, Congenic, and Segregating Inbred Strains -- Recombinant Inbred (RI) Strains -- Genes -- Loci That Are Members of a Series -- Alleles -- Transgenes -- Outbred Stocks -- QUALITY -- Microbiologic Quality -- Genetic Quality -- SELECTED ASPECTS OF EXPERIMENTAL DESIGN -- ; REFERENCES -- 4 Genetic Management of Breeding Colonies -- GENETICALLY DEFINED STOCKS -- Pedigrees -- Traceability -- Selection of Parental Pairs -- Genetic Uniformity -- Foundation or Nucleus Colonies, Expansion Colonies, and Production Colonies -- NONGENETICALLY DEFINED STOCKS -- CRYOPRESERVATION -- RECORD-KEEPING -- REFERENCES -- 5 Husbandry -- HOUSING -- Caging -- Housing Systems -- Space Recommendations -- ENVIRONMENT -- Microenvironment -- Temperature -- Humidity -- Ventilation -- Ventilation Rate -- Air Quality -- Relative Air Pressures -- Cage Ventilation -- Illumination -- Spectral Distribution -- Photoperiod -- Intensity -- Noise -- FOOD -- Types of Diets -- Criteria for Selecting Optimal Rations -- Quality Assurance -- Caloric Restriction -- WATER -- BEDDING -- SANITATION -- Cleaning -- Waste Containment and Disposal -- Pest Control -- IDENTIFICATION AND RECORDS -- RODENTS OTHER THAN RATS AND MICE -- Guinea Pigs.; Hamsters -- Gerbils -- Chinchillas -- REFERENCES -- 6 Veterinary Care -- PREVENTIVE MEDICINE -- Procurement -- Sources -- Transportation -- Quarantine and Stabilization -- Separation by Species, Source, and Health Status -- SURVEILLANCE, DIAGNOSIS, TREATMENT, AND CONTROL OF DISEASE -- Daily Observations of Animals -- Control of Infectious Diseases -- Sample Size for Monitoring -- Treatment and Control -- Necropsies -- EMERGENCY, WEEKEND, AND HOLIDAY CARE -- MINIMIZATION OF PAIN AND DISTRESS -- Recognition of Pain and Distress -- Alleviation of Pain -- Alleviation of Stress and Distress -- SURVIVAL SURGERY AND POSTSURGICAL CARE -- Anesthetics and Tranquilizers -- Preparation for Survival Surgery -- Sterilization of Instruments -- Monitoring During Surgery -- Postoperative Care -- EUTHANASIA -- REFERENCES -- 7 Facilities -- LOCATION AND DESIGN -- Centralization Versus Decentralization -- Functional Areas -- Space Requirements -- Relative Relationships of Space -- Corridors, Vestibules, and Anterooms -- Interstitial Space -- CONSTRUCTION AND ARCHITECTURAL FINISHES -- MONITORING -- SPECIAL REQUIREMENTS -- SECURITY -- REFERENCES -- 8 Rodents that Require Special Consideration -- IMMUNODEFICIENT RODENTS -- Husbandry -- Plastic Cages with Filter Tops -- Individually Ventilated Plastic Cages with Filter Tops -- Isolators -- HEPA-Filtered Airflow Systems -- Environmental Considerations -- Food and Bedding -- Water -- Health Monitoring -- WILD RODENTS -- Hazards -- Care and Breeding -- Peromyscus -- Woodchucks -- AGING COHORTS -- General Considerations -- Laboratory Mice -- Rats (Rattus norvegicus) -- Husbandry -- Record-Keeping -- Transportation and Stabilization -- Veterinary Care and Surveillance -- Other Rodent Species Used for Gerontological Research -- Other Species of Mus -- Peromyscus spp. -- Guinea Pigs -- Hamsters -- Gerbils.; RODENT MODELS OF INSULIN-DEPENDENT DIABETES MELLITUS -- Diabetes-Prone and Diabetes-Resistant Rats -- Breeding Techniques and Genetic Records -- Husbandry and Care -- Use of Spleen Cells to Reduce Frequency of Diabetes and Improve Breeding Efficiency -- Shipping Pathogen-Free Rats -- NOD Mice -- TRANSGENIC MICE -- Colony Management -- Embryo Donors -- Embryo Recipients -- Offspring -- Breeding Transgenic Mice -- Identification, Records, and Genetic Monitoring -- Embryo Cryopreservation -- Data Management -- Shipment and Receipt of Transgenic Rodents -- Human Health Hazards -- Administrative Issues -- REFERENCES -- Appendix Sources of Information on Importing Rodents -- Index.
• Sommario/riassunto: During the 15 years since the Institute of Laboratory Animal Resources issued its last report on the general management of rodents, advances in biomedical technology and increased public awareness of laboratory ; animal issues have created a new research environment. This book brings researchers up to date on both of these aspects of laboratory investigation and provides a comprehensive resource manual for management of laboratory rodents. It reviews relevant laws and ethical considerations, and it examines the role and responsibilities of mandatory institutional animal care and use committees. The expert panel addresses animal selection, sources of laboratory rodents, nomenclature and record keeping, management of genetically and nongenetically defined colonies, and management of animals with special needs. Investigators will find detailed guidance on housing, environment, sanitation, diet and caloric restriction, and facilities design.