| |
|
|
|
|
|
|
|
|
1. |
Record Nr. |
UNINA9910688341403321 |
|
|
Autore |
Giuseppe Rengo |
|
|
Titolo |
The adrenergic system in cardiovascular physiology and pathophysiology [[electronic resource] /] / edited by: Giuseppe Rengo |
|
|
|
|
|
|
|
Pubbl/distr/stampa |
|
|
Frontiers Media SA, 2015 |
|
[Lausanne, Switzerland] : , : Frontiers Media SA, , 2015 |
|
©2015 |
|
|
|
|
|
|
|
|
|
Edizione |
[Second edition.] |
|
|
|
|
|
Descrizione fisica |
|
1 online resource (78 pages) : illustrations; digital, PDF file(s) |
|
|
|
|
|
|
Collana |
|
Frontiers Research Topics |
Frontiers in Physiology |
|
|
|
|
|
|
|
|
Soggetti |
|
Cardiovascular system - Diseases |
Cardiovascular system - Diseases - Pathogenesis |
Cardiovascular system - Diseases - Prevention - Research |
|
|
|
|
|
|
|
|
Lingua di pubblicazione |
|
|
|
|
|
|
Formato |
Materiale a stampa |
|
|
|
|
|
Livello bibliografico |
Monografia |
|
|
|
|
|
Nota di bibliografia |
|
Includes bibliographical references. |
|
|
|
|
|
|
Sommario/riassunto |
|
Cardiovascular diseases pose an enormous clinical challenge, remaining the most common cause of death in the world. β-adrenoceptors play an important role on cardiac, vascular and/or endothelial function at a cellular level with relevant applications in several cardiovascular diseases, such as heart failure and hypertension. G protein–coupled receptors (GPCRs), including β-adrenergic receptors, constitute the most ubiquitous superfamily of plasma membrane receptors and represent the single most important type of therapeutic drug target. Sympathetic nervous system hyperactivity, which characterizes several cardiovascular diseases, such as heart failure and hypertension, as well as physiological ageing, has been proved to exert in the long-term detrimental effects in a wide range of cardiovascular diseases. Acutely, sympathetic hyperactivity represents the response to an insult to the myocardium, aiming to compensate for decreased cardiac output. This process involves the activation of beta-adrenergic receptors by catecholamine with consequent heart rate and cardiac contractility increase. However, long-term exposure of the heart to |
|
|
|
|
|
|
|
|
|
|
|
|
|
elevated norepinephrine and epinephrine levels, originating from sympathetic nerve endings and chromaffin cells of the adrenal gland, results in further progressive deterioration in cardiac structure and function. At the molecular level, sustained sympathetic nervous system hyperactivity is responsible for several alterations including altered beta-adrenergic receptor signaling and function (down-regulation/desensitization). Moreover, the detrimental effects of catecholamine affect also the function of different cell types including, but not limited to, endothelial cells, fibroblasts and smooth muscle cells. Thus, the success of beta-blocker therapy is due, at least in part, to the protection of the heart and the vasculature from the noxious effects of augmented catecholamine levels. The current research topic aims to support the progress towards understanding the role of sympathetic nervous system under physiological conditions, and the contribution of its hyperactivity in the pathogenesis and progression of cardiovascular diseases. The topic is open to original studies, descriptions of new methodologies, reviews and opinions. |
|
|
|
|
|
|
2. |
Record Nr. |
UNINA9910969208703321 |
|
|
Autore |
Cobb Kelton |
|
|
Titolo |
The Blackwell Guide to Theology and Popular Culture |
|
|
|
|
|
Pubbl/distr/stampa |
|
|
|
|
|
|
ISBN |
|
1-281-31940-6 |
9786611319403 |
0-470-77473-8 |
0-470-77770-2 |
|
|
|
|
|
|
|
|
Descrizione fisica |
|
1 online resource (366 p.) |
|
|
|
|
|
|
Collana |
|
Blackwell guides to theology |
|
|
|
|
|
|
Disciplina |
|
|
|
|
|
|
Soggetti |
|
Christianity |
Popular culture |
Popular culture - Religious aspects |
Popular culture - Religious aspects - Christianity |
Religious aspects |
Religion |
Philosophy & Religion |
|
|
|
|
|
|
|
|
Lingua di pubblicazione |
|
|
|
|
|
|
Formato |
Materiale a stampa |
|
|
|
|
|
|
|
|
|
|
Livello bibliografico |
Monografia |
|
|
|
|
|
Note generali |
|
Description based upon print version of record. |
|
|
|
|
|
|
Nota di contenuto |
|
Contents; Acknowledgments; Introduction; Part I Theories of Popular Culture; 1 Popular Culture; 2 Cultural Studies; 3 Theology and Culture; 4 Theological Tools; Part II A Theology of Popular Culture; 5 Images of God; 6 Human Nature; 7 Sin; 8 Salvation; 9 Life Everlasting; Conclusion; Notes; Bibliography; Index |
|
|
|
|
|
|
|
|
Sommario/riassunto |
|
The Blackwell Guide to Theology of Popular Culture outlines various general theories of popular culture, identifies theologians and theological concepts that are conducive to analyzing popular culture, and explores religious themes that are asserting themselves through popular movies, novels, music, television shows and advertising. A timely examination and contribution to the rapidly expanding field of theology and popular culture Locates the theological analysis of culture alongside political, sociological, economic, aesthetic and psychological analyses Surveys |
|
|
|
|
|
|
|
| |