Thiol metabolism and redox regulation of cellular functions / / [edited by] Alfonso Pompella, Gabor Banhegyi, Maria Wellman-Rousseau

• Record Nr.: UNINA9910967929703321
• Pubbl/distr/stampa: Amsterdam ; ; Washington, DC, : IOS Press, c2002
• ISBN: 1-280-50567-2; 9786610505678; 600-00-0589-X; 1-60129-472-7
• Edizione: [1st ed.]
• Descrizione fisica: 1 online resource (365 pages) : illustrations
• Collana: NATO science series. Series I, Life and behavioural sciences, , 1566-7693 ; ; v. 347
• Altri autori (Persone): PompellaAlfonso; BánhegyiGábor; Wellman-RousseauMaria
• Disciplina: 572.7
• Soggetti: Antioxidants; Thiols - Physiological effect; Glutathione - Physiological effect; Oxidation-reduction reaction; Cell respiration
• Lingua di pubblicazione: Inglese
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Note generali: "Published in cooperation with NATO Scientific Affairs Division."; "Proceedings of the NATO Advanced Research Workshop on Thiol Metabolism and Redox Regulation of Cellular Functions, 10-13 April 2002, Pisa, Italy"--T.p. verso.
• Nota di bibliografia: Includes bibliographical references and index.
• Nota di contenuto: Cover; Title page; Foreword; Preface; Contributors; Contents; Oxidative Signaling and Glutathione Synthesis; Cell Survival and Changes in Gene Expression in Cells Unable to Synthesize Glutathione; Role of Glutathione in the Regulation of Liver Metabolism; Glutathione Transport in the Endo/Sarcoplasmic Reticulum; Role of Ascorbate in Oxidative Protein Folding; Cytophotometric Investigations on Oscillating Thiol-Disulfide Equilibria and Oxidized Protein Sulfur; Protection by Pantothenic Acid against Apoptosis and Cell Damage by Oxygen Free Radicals - The Role of Glutathione; Thiols as Major Determinants of the Total Antioxidant Capacity; ; Enzymes of the Thiol-dependent Hydroperoxide Metabolism in Pathogens as Potential Drug Targets; Is there a Role of Glutathione Peroxidases in Signaling and Differentiation?; Multidrug Resistance-associated Proteins: Export Pumps for Conjugates with Glutathione, Glucuronate or Sulfate; Detoxification of Electrophilic Compounds by Glutathione S-Transferase Catalysis: Determinants of Individual Response to Chemical Carcinogens and...; Transcriptional Regulation of Glutathione S-Transferase P1-1 in Human Leukemia; Mechanism of γ-Glutamyltranspeptidase Folding and Activation in the Endoplasmic Reticulum; The Role of γ-Glutamyl Transpeptidase in the Biosynthesis of Glutathione; Role of γ-Glutamyltransferase in the Homeostasis of Glutathione during Oxidative and Nitrosative Stress; The Importance of gamma-Glutamyl Transferase in Lung Glutathione Homeostasis and Antioxidant Defense; The Role of gamma-Glutamyltranspeptidase in the Metabolism and Cytotoxicity of 4-Hydroxynonenal-Glutathione Conjugate: Evidence and Hypothesis; γ-Glutamyltransferase-Dependent Prooxidant Reactions: a Factor in Multiple Processes; Serum gamma-Glutamyl Transpeptidase: a Prognostic Marker in Cardiovascular Diseases; Lipoic Acid: a Multifunctional Antioxidant; Is Glutathione an Important Neuroprotective Effector Molecule against Amyloid Beta Toxicity?; Antioxidants in Cancer Therapy: is there a Rationale to Recommend Antioxidants during Cancer Therapy?; Disulfide Exchange in CD4; Redox Regulation in Protein Folding and Chaperone Function; Reduction of the Endoplasmic Reticulum Accompanies the Oxidative Damage of Diabetes Mellitus; Analytical Developments in the Assay of Intra- and Extracellular GSH Homeostasis; Signalling Potential and Protein Modifying Ability of Physiological Thiols; Redox Signaling and the Map Kinase Pathways; Redox Regulation of Mitochondrial Permeability Transition: Contrasting Effects of Lipoic Acid and its Positively Charged Analog LA-Plus; Redox State of Glutathione and Thioredoxin in Differentiation and Apoptosis; Redox Regulation of DNA Repair; Author Index
• Sommario/riassunto: This volume contains contributions by some of the leading scientists in the field of thiol oxidation/reduction (redox) biochemistry. It is focused on the biological/pathophysiological implications of newly-discovered functions of cellular thiols, such as glutathione in the first place.