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Record Nr. |
UNINA9910967797203321 |
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Autore |
Vinšová Jarmila |
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Titolo |
Development of new MDR-tuberculosis drugs / / Jarmila Vinšová and Martin Krátký |
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Pubbl/distr/stampa |
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New York, : Nova Science Publishers/Nova Biomedical, c2010 |
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ISBN |
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Edizione |
[1st ed.] |
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Descrizione fisica |
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1 online resource (112 p.) |
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Collana |
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Pharmacology-research, safety testing and regulation |
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Altri autori (Persone) |
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Disciplina |
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Soggetti |
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Antitubercular agents |
Multidrug-resistant tuberculosis - Chemotherapy |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references and index. |
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Nota di contenuto |
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Resistance to commonly used drugs, mechanism of the action -- Research of novel MDR potential drugs. |
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Sommario/riassunto |
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The emergence of resistance to anti-tuberculosis drugs, particularly of MDR-TB and newly XDR-TB, has become a major public health problem. The current treatment regiment has several disadvantages, i.e. long treatment period (DOTS takes minimum 6 months) during which tubercle bacilli mutant become resistant to one or more drugs; side effects of the used drugs; co-infection of HIV/AIDS. The emergence of MDR-TB has made many currently available anti-TB drugs ineffective. Sleeping latent forms of mutant bacilli resistant against common anti-TB drugs pose the risk of epidemic for the new generation. This book outlines the recent advances in the development of new multi-drug-resistant tuberculosis (MDR-TB) drugs. |
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