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1. |
Record Nr. |
UNINA9910461559803321 |
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Autore |
Greenfield Stanley B. |
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Titolo |
Hero and exile : the art of old English poetry / / Stanley B. Greenfield ; edited by George H. Brown |
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Pubbl/distr/stampa |
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London, England ; ; Ronceverte, West Virginia : , : The Hambledon Press, , 1989 |
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©1989 |
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ISBN |
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1-283-20205-0 |
9786613202055 |
0-8264-4340-0 |
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Descrizione fisica |
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1 online resource (255 p.) |
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Disciplina |
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Soggetti |
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English poetry - Old English, ca. 450-1100 - History and criticism |
Elegiac poetry, English (Old) - History and criticism |
Civilization, Anglo-Saxon, in literature |
Civilization, Medieval, in literature |
Exile (Punishment) in literature |
Electronic books. |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Nota di contenuto |
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Contents; Introduction; Acknowledgements; I: BEOWULFIAN STUDIES; II: THE OLD ENGLISH ELEGIES; III: THE THEME OF EXILE; Index |
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2. |
Record Nr. |
UNINA9910482175103321 |
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Autore |
Augustine, Saint |
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Titolo |
D. Aurelii Augustini Hippon. episcopi Libri XIII confessionum ad 3 m.s.s. exemp. emendati.-fOpera et studio R.P.H. Sommalii . [[electronic resource]] |
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Pubbl/distr/stampa |
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Leiden, : Daniel Elzevir, 1626-1680, 1675 |
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Descrizione fisica |
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Online resource (334, [17] p, 12°) |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Reproduction of original in Koninklijke Bibliotheek, Nationale bibliotheek van Nederland. |
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3. |
Record Nr. |
UNINA9910967542303321 |
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Autore |
Kim Sang Geon |
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Titolo |
AMPK-S6K1 signaling pathway as a target for treating hepatic insulin resistance / / Sang Geon Kim, Il Je Cho and Hee Yeon Kay |
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Pubbl/distr/stampa |
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New York, : Nova Science Publishers, c2010 |
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ISBN |
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Edizione |
[1st ed.] |
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Descrizione fisica |
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1 online resource (69 p.) |
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Collana |
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Hepatology research and clinical developments series |
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Altri autori (Persone) |
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Disciplina |
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Soggetti |
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Insulin resistance - Molecular aspecsts |
Liver - Diseases - Molecular aspecsts |
Protein kinases |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references (p. [33]-49) and index. |
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Nota di contenuto |
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Introduction: Insulin signaling in hepatocytes -- Clinical and preclinical drugs for the treatment of hepatic insulin resistance. |
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Sommario/riassunto |
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Hepatic insulin resistance and altered insulin metabolism, as characterized by the desensitization of hepatic parenchymal cells to insulin, play a role in the pathogenesis of liver disease, particularly resulting in steatosis and steatohepatitis. By the same token, type II diabetic patients are at higher risk for developing liver diseases, including steatosis, hepatitis, cirrhosis, and hepatocellular carcinoma. On the other hand, established liver disease from any cause leads to glucose intolerance and peripheral insulin resistance systemically. The link between insulin resistance and liver pathology reviewed in this book suggests that insulin resistance is closely related with a variety of liver diseases. Recent evidence indicates that the AMP activating protein kinase (AMPK) in conjunction with p70 ribosomal S6 kinase 1 (S6K1) serves as a key signaling pathway regulating insulin-dependent physiological functions; thus, this pathway serves as a target for the therapy of diseases associated with insulin resistance. In this chapter, the regulatory role of the AMPK-S6K1 pathway is discussed in terms of enhancing insulin receptor signaling with insulin receptor substrate-1/2 and phosphatidylinositol phosphate kinase activity, which may contribute to preventing and/or treating insulin resistance in the liver. |
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