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1. |
Record Nr. |
UNINA9910743382103321 |
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Titolo |
Ankylosing spondylitis - Axial spondyloarthritis : cellular, molecular and environmental factors / / edited by Mohammad Hossein Nicknam |
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Pubbl/distr/stampa |
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Gateway East, Singapore : , : Springer, , [2022] |
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©2022 |
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ISBN |
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981-16-4733-X |
981-16-4732-1 |
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Descrizione fisica |
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1 online resource (188 pages) |
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Disciplina |
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Soggetti |
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Ankylosing spondylitis - Molecular aspects |
Ankylosing spondylitis |
Spondylitis, Ankylosing |
Espondiloartritis anquilosant |
Llibres electrònics |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Nota di bibliografia |
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Includes bibliographical references and index. |
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Nota di contenuto |
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Intro -- Preface -- Contents -- About the Editor -- Part I: Introduction -- 1: An Overview to Ankylosing Spondylitis and Spondyloarthropathies -- 1.1 History -- 1.2 Epidemiology -- 1.3 Clinical Manifestation -- 1.3.1 General Symptoms, Spondylitis and Arthritis -- 1.3.2 Extra-Articular Manifestations -- 1.3.3 Complications and Co-morbidities -- 1.4 Diagnosis -- 1.4.1 History and Physical Examination -- 1.4.2 Lab Test -- 1.4.3 Imaging -- 1.4.3.1 Plain Radiography -- 1.4.3.2 Computed Tomography -- 1.4.3.3 Magnetic Resonance Imaging -- 1.4.4 Classification and Diagnostic Criteria -- 1.5 Pathogenesis -- 1.6 Treatment -- 1.6.1 Nonsteroidal Anti-Inflammatory Drugs -- 1.6.2 Glucocorticoids -- 1.6.3 Disease-Modifying Anti-Rheumatic Drugs -- 1.7 Conclusion -- References -- Part II: Cells and Cytokines -- 2: Innate Immune-Related Cells and Cytokines in Spondyloarthropathies -- 2.1 Introduction -- 2.2 Innate Immunity Components -- 2.2.1 Pattern Recognition Receptors (PRR) -- 2.2.1.1 Toll-Like Receptors (TLRs) -- 2.2.1.2 NOD-Like Receptors (NLRs) -- 2.2.2 Innate Cytokines -- 2.2.2.1 IL-1 Family -- 2.2.2.1.1 IL-1 and Receptors -- |
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2.2.2.1.2 IL-37 -- 2.2.2.2 TNF and Receptors -- 2.2.2.3 IL-23 and Receptor -- 2.2.3 Soluble Components of Innate Immunity -- 2.2.3.1 Defensins -- 2.2.3.2 Complement System -- 2.2.4 Innate Immune Cells -- 2.2.4.1 Dendritic Cells (DC) -- 2.2.4.2 Macrophage Cells -- 2.2.4.3 Natural Killer (NK) Cells -- References -- 3: Adaptive Immune-Related Cells and Cytokines in Spondyloarthropathies -- 3.1 Adaptive immunity in autoimmune disorders -- 3.2 The Pathogenic Role of Adaptive Immune Lymphocytes in SpAs -- 3.3 T Cell Activation, Signaling, and Cytokines in SpAs -- 3.3.1 Th1 and Th2 role in SpAs -- 3.3.2 Th17 and IL-17 in SpAs -- 3.3.2.1 IL-17 and Enthesitis -- 3.3.2.2 IL-17 and Bone Remodeling. |
3.3.2.3 Targeting Th17 in SpAs -- 3.3.3 Th22 and IL-22 in SpAs -- 3.3.4 Functional Abnormalities of Regulatory T Cells in SpAs -- 3.3.5 Cytotoxic T Cell in SpAs -- 3.3.6 Gamma Delta T Cells and SpAs -- 3.4 B Cell Activation and Signaling -- 3.5 Conclusions and Future Directions -- References -- Part III: Genes -- 4: Association of HLA and HLA-Related Genes with Ankylosing Spondylitis -- 4.1 Biology of HLA Expression and Functions -- 4.1.1 Genomic Organization -- 4.1.1.1 HLA Nomenclature -- 4.1.2 Molecular Structure -- 4.1.2.1 Molecular Structure of HLA-Class I -- 4.1.2.2 Molecular Structure of HLA-Class II -- 4.1.3 Pathways of Antigen Presentation -- 4.1.3.1 Processing and Presentation of Endocytosed Antigens -- 4.1.3.2 Processing and Presentation of Cytosolic Antigens -- 4.2 Association of HLA loci with Ankylosing Spondylitis -- 4.2.1 HLA-B27 -- 4.2.1.1 Arthritogenic Peptide Hypothesis -- 4.2.1.2 HLA-B27 Misfolding Hypothesis -- 4.2.1.3 HLA-B27 Dimer Hypothesis -- 4.2.2 HLA Genes Other Than HLA-B27 -- 4.3 Association of HLA-Related Genes with Ankylosing Spondylitis -- 4.3.1 Transporters in Antigen Presenting (TAP) -- 4.3.2 M1 zinc-Aminopeptidases -- 4.3.2.1 Endoplasmic Reticulum Aminopeptidase (ERAP)-1 -- 4.3.2.2 ERAP2 -- 4.3.2.3 NPEPPS -- 4.3.2.4 Ubiquitinases -- 4.3.2.5 LMP2 -- 4.4 Role of Epigenetics in Ankylosing Spondylitis Pathogenesis -- 4.4.1 DNA Methylation -- 4.4.2 Histone Modifications -- 4.4.3 MicroRNAs -- References -- 5: Association of Non-HLA Genes with Ankylosing Spondylitis -- 5.1 Cytokines and Cytokine-Receptors -- 5.1.1 IL-1RN Gene -- 5.1.2 IL-6 Receptor Gene -- 5.1.3 IL-12B Gene -- 5.1.4 IL-17 Gene -- 5.1.5 IL-23 and IL-23 Receptor -- 5.1.6 TNF and TNF Receptor -- 5.1.7 IL-10 Gene -- 5.2 Overview on Signal Transduction -- 5.2.1 VDR Gene -- 5.2.2 TLR4 Gene. |
5.2.3 G Protein-Coupled Receptor Gene -- 5.2.4 CTLA-4 Gene -- 5.2.5 PD-1 Gene -- 5.2.6 PTPN22 Gene -- 5.2.7 CARD9 Gene -- 5.2.8 TBKBP1 Gene -- 5.2.9 TRADD Gene -- 5.2.10 STAT3 Gene -- 5.2.11 STAT4 Gene -- 5.2.12 RUNX3 Gene -- 5.2.13 TBX21 Gene -- 5.2.14 Ancillary Mediators Involved in Lymphocyte Differentiation -- 5.3 Other Associated Genes with AS Disease -- 5.3.1 ANTXR2 -- 5.3.2 SNAPC4 -- 5.3.3 KIF21B -- 5.3.4 PTGER4 -- 5.3.5 PPARGC1B -- 5.3.6 ANO6 Gene -- 5.3.7 Β-Defensin Gene Clusters -- 5.3.8 Pentraxin3 -- 5.3.9 MIF Gene -- 5.3.10 BCL11B -- 5.3.11 Autophagy-Related Genes -- References -- Part IV: Environmental Factors -- 6: Spondyloarthropathies and Gut Microbiota -- 6.1 Introduction -- 6.2 Gut Microbiome -- 6.3 Spondyloarthropathies and Microbes -- 6.4 Spondyloarthropathies and Inflammatory Bowel Diseases -- 6.5 Animal Models of SpA and Gut Immunity -- 6.6 Dysbiosis and Inflammation in SpA -- 6.7 HLA-B27 -- 6.8 Cytokines Induction by Microbiome -- 6.9 Probiotics and Prebiotics -- 6.10 Antibiotics and Fecal Transplant -- 6.11 Conclusion -- References -- 7: Spondyloarthropathies and Food Intake -- 7.1 Introduction -- 7.1.1 Spondyloarthropathies -- 7.1.2 Ankylosing Spondylitis -- 7.2 |
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Vitamins -- 7.2.1 Vitamin D -- 7.2.2 Other Vitamins -- 7.2.2.1 Vitamin E -- 7.2.2.2 Vitamin A -- 7.3 Low Starch Diet and Klebsiella -- 7.4 Fatty Acids -- 7.5 Obesity -- 7.6 Food Allergy -- 7.7 Conclusion -- References -- 8: Spondyloarthropathies and Environmental Stresses -- 8.1 Introduction -- 8.2 Biomechanical Stress -- 8.3 Psychological Stress -- 8.4 Oxidative Stress -- 8.5 Smoking -- 8.6 Vaccination -- References -- Index. |
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2. |
Record Nr. |
UNINA9910967353503321 |
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Autore |
Techt Uwe |
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Titolo |
Goldratt and the Theory of Constraints : The Quantum Leap in Management / Uwe Techt, VISTEM GmbH u. Co. KG |
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Pubbl/distr/stampa |
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ISBN |
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Edizione |
[1st ed.] |
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Descrizione fisica |
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1 online resource (175 p.) |
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Collana |
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QuiStainable Business Solutions |
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Disciplina |
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Soggetti |
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Corporate Strategy |
Goldratt |
business |
management |
Buffer Management |
theory |
strategy |
theories |
constraints |
Throughput Accounting |
Irresistible Offer |
Theory of Constraints |
Pull Distribution |
Viable Vision |
Drum-Buffer-Rope |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di contenuto |
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Productivity (P)Investment Turns (IT); Food for thought; What keeps us from earning money?; There is a constraint!; Five steps toward continuous improvement; 1. Identify the constraint; 2. Decide how to optimize use of the constraint; 3. Everything else must be subordinate to thisone decision; 4. Elevate the constraint; 5. Start over if the constraint shifts; Food for thought; We are not producing enough!; Problem: Local optima; Dilemma: But we do need local optima!; Idle resources are a waste; Solution: Drum Buffer Rope; Drum; Buffer; Relay runner work ethic; Buffer management |
The dangers of successShifting the constraint; Relay runner work ethic; Buffer management; The dangers of success; Shifting the constraint; Food for thought; What about finances?; Dilemma: Throughput vs. Costs; The chain analogy; Managing the chain in the "cost world"; Managing the chain in the "throughput world"; The core conflict; Do costs really follow the additive rule?; Solution: The Throughput accounting system; How much profit do we make from our products?; Find the constraint; Determine the throughput created by the product; Determine usage of the constraint |
Calculate the relationship between throughput andconstraint usageBusiness profit; Is the investment worth it?; Impact of Investment on Throughput; Increasing the constraint's capacity; Increasing the demand for X; Decreasing the costs of raw materials or purchased parts; Conclusions; Impact of Investment on Operating Expenses; Impact of Investment on Inventory and Investment Levels (I); Manufacturing yourself or purchasing?; What about inventory?; Food for thought; What lies behind the constraint?; The inherent simplicity of complex systems; An analogy: A visit to the doctor; Diagnosis |
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Sommario/riassunto |
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Businessmen and managers, consultancy clients, readers of the Goldratt novels, and workshop attendees often ask: What is this Theory of Constraints? How can it benefit me? How is it different from other management theories? Is there something I can read to quickly understand its fundamentals? This book is an answer to these questions. Using engaging language and offering many real-life examples, it provides an overview of the methods and tools of the Theory of Constraints: Drum-Buffer-Rope, Buffer Management, Throughput Accounting, Pull Distribution, Irresistible Offer, Corporate Strategy, and Viable Vision. You will learn how to recognize and use constraints, how to complete projects quickly and reliably, and how to gain a competitive lead and to turn it into profit. |
"Excellent, very recommendable!"?Wolfram Müller, Speed4Projects.Net |
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