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UNINA9910346753903321 |
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Autore |
Atsuyoshi Shimada |
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Titolo |
Neuroimmune Interface in Health and Diseases |
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Pubbl/distr/stampa |
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Descrizione fisica |
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1 online resource (174 p.) |
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Collana |
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Frontiers Research Topics |
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Soggetti |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Sommario/riassunto |
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It is now well appreciated that the immune system, in addition to its traditional role in defending the organism against pathogens, communicate in a well-organized fashion with the brain to maintain homeostasis and regulate a set of neural functions. Perturbation in this brain-immune interactions due to inflammatory responses may lead to psychiatric and neurological disorders. Microglia are one of the essential cells involved in the brain-immune interactions. Microglial cells are now not simply regarded as resident tissue macrophages in the brain. These cells are derived from myeloid progenitor cells in the yolk sac in early gestation, travel to the brain parenchyma and interact actively with neurons during the critical period of neurogenesis. Microglia provide a trophic support to developing neurons and take part in the neural wiring through the activity-dependent synapse elimination via direct neuron-microglia interactions. Altered microglial functions including changes in the gene expression due to early life inflammatory events or psychological and environmental stressors can be causally related to neurodevelopmental diseases and mental health disorders. This type of alterations in the neural functions can occur in the absence of infiltration of inflammatory cells in the brain parenchyma or leptomeninges. In this sense, the pathogenetic state underlying a significant part of psychiatric and neurological diseases may be similar to "para-inflammation", an intermediate state between homeostatic and classical inflammatory states as defined by Ruslan |
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Medzhitov (Nature 454:428-35, 2008). Therefore, it is important to study how systemic inflammation affects brain health and how local peripheral inflammation induces changes in the brain microenvironment. Chronic pain is also induced by disturbance in otherwise well-organized multisystem interplay comprising of reciprocal neural, endocrine and immune interactions. Especially, early-life insults including exposure to immune challenges can alter the neuroanatomical components of nociception, which induces altered pain response later in life. Recently the discrete roles of microglia and blood monocyte-derived macrophages are being defined. The distinction may be further highlighted by disorders in which the brain parenchymal tissue is damaged. Therefore, studies investigating the dynamics of immune cells in traumatic brain injury and neurotropic viral infections including human immunodeficiency virus, etc. as well as neurodegenerative diseases such as amyotrophic lateral sclerosis are promising to clarify the interplay between the central nervous and immune systems. The understanding of the histological architecture providing the infrastructure of such neuro-immune interplay is also essential. This Frontiers research topic brings together fourteen articles and aims to create a platform for researchers in the field of psychoneuroimmunology to share the recent theories, hypotheses and future perspectives regarding open questions on the mechanisms of cell-cell interactions with chemical mediators among the nervous, immune and endocrine systems. We hope that this platform would reveal the relevance of the studies on multisystem interactions to enhance the understanding of the mechanisms underlying a wide variety of neurological and psychiatric disorders. |
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2. |
Record Nr. |
UNINA9910966587103321 |
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Autore |
Labrecque Joseph |
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Titolo |
Adobe Edge Quickstart guide / / Joseph Labrecque |
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Pubbl/distr/stampa |
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Birmingham, UK : , : Packt Publishing, , 2012 |
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London : , : Bloomsbury Publishing (UK), , 2025 |
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ISBN |
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9786613531261 |
9781280127380 |
1280127384 |
9781849693318 |
1849693315 |
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Edizione |
[1st ed.] |
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Descrizione fisica |
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1 online resource (136 p.) |
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Collana |
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Community experience distilled |
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Disciplina |
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Soggetti |
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HTML (Document markup language) |
Web sites - Design |
Digital animation |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references and index. |
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Nota di contenuto |
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Cover; Copyright; Credits; About the Author; About the Reviewer; www.PacktPub.com; Table of Contents; Preface; Chapter 1: Introduction to Adobe Edge; Why we need Adobe Edge; Flash Player restrictions; The relationship between Adobe Edge and Adobe Flash Professional; Comparisons with Adobe Flash Professional; Stage; Timeline; Keyframes; Symbols; Library; Actions; HTML technology maturity; Mobile deployment; What Adobe Edge can be used for; Web animation; Interactive content; The history of Adobe Edge; The inner workings of Edge; HTML, CSS, and JavaScript; HTML; CSS; JavaScript |
How jQuery is used in EdgeJSON; The Adobe Edge Runtime; Getting started; Installing Adobe Edge; The Adobe Edge welcome screen; Creating a new Edge Project; Save; Save As...; Edge project file structure; Summary; Chapter 2: The Edge Application Interface; Application interface overview; The application window; Customizing the Edge panel layout; Managing workspaces; The Edge menu system; File; Edit; View; Modify; Timeline; Window; Help; The Edge Toolbar; Selection tool; Transform tool; Rectangle tool; Rounded Rectangle tool; |
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Text tool; Background Color and Border Color; The Stage |
The Edge TimelinePanels in Edge; Elements panel; Library panel; Properties panel; Actions panel; Summary; Chapter 3: Working with Edge Tools and Managing Assets; Using the drawing tools; The Rectangle tool; Using the Rectangle tool; The Rounded Rectangle tool; Using the Rounded Rectangle tool; The Text tool; Using the Text tool; Using web fonts; The Selection and Transform tools; Using the Selection tool; Color tools; Importing external assets; What is SVG?; Importing SVG images; What is a bitmap?; Importing bitmap Images; Working with imported assets; Converting assets into symbols |
Create a SymbolSummary; Chapter 4: Creating Motion with Edge; Animation within Edge; The Edge Timeline; Playback controls; Time; Search; Timeline options; Timeline controls; The Playhead; The Mark; Zoom controls; Keyframes; Creating motion; Animating with the Playhead; Animating with the Mark; Editing Transition; Duration; Delay; End; Easing; Example: Animating a website header; Project setup, asset import, and general layout; Animating elements; Summary; Chapter 5: Adding Interactivity to an Edge Composition; Working with Actions; The Timeline Actions layer; Working with Triggers |
Working with LabelsApplying Actions to the Stage; Applying Actions to individual elements; Overview: The Adobe Edge Runtime APIs; Document Object Model events; Mouse events; Touch events; Virtual mouse events; Timeline events; Example: Adding interactivity to a website header; Creating the Text element; Adding interactivity to the Title; Adding interactivity to the album art; Completing the final website header composition; Summary; Chapter 6: Additional Resources; Using an Edge composition within an existing website; Online resources; About the forthcoming book: Learning Adobe Edge |
Learning Adobe Edge |
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Sommario/riassunto |
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Adobe Edge Quickstart Guide is a practical guide on creating engaging content for the Web with Adobe's newest HTML5 tool. By taking a chapter-by-chapter look at each major aspect of Adobe Edge, the book lets you digest the available features in small, easily understandable chunks, allowing you to start using Adobe Edge for your web design needs immediately. If you are interested in creating engaging motion and interactive compositions using web standards with professional tooling, then this book is for you. Those with a background in Flash Professional wanting to get started quickly with Adobe |
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