Modern alkaloids : structure, isolation, synthesis and biology / / edited by Ernesto Fattorusso and Orazio Taglialatela-Scafati

• Record Nr.: UNINA9911019549103321
• Pubbl/distr/stampa: Weinheim, : Wiley-VCH, c2008
• ISBN: 9786611311810; 9781281311818; 1281311812; 9783527621071; 3527621075; 9783527621088; 3527621083
• Descrizione fisica: 1 online resource (691 p.)
• Altri autori (Persone): FattorussoErnesto; Taglialatela-ScafatiOrazio
• Disciplina: 572.549
• Soggetti: Alkaloids - Structure; Alkaloids
• Lingua di pubblicazione: Inglese
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Note generali: Description based upon print version of record.
• Nota di bibliografia: Includes bibliographical references and index.
• Nota di contenuto: Modern Alkaloids; Contents; Preface; List of Contributors; I Bioactive Alkaloids: Structure and Biology; 1 Ecological Roles of Alkaloids; 1.1 Introduction: Defense Strategies in Plants; 1.2 Ecological Roles of Alkaloids; 1.3 Modes of Action; 1.3.1 Unspecific Interactions; 1.3.2 Specific Interactions; 1.3.3 Cytotoxicity of Alkaloids; 1.4 Evolution of Alkaloidal Defense Systems; 1.5 Conclusions; 2 Antitumor Alkaloids in Clinical Use or in Clinical Trials; 2.1 Introduction; 2.2 Antitumor Alkaloids in Clinical Use; 2.2.1 Vinca Alkaloids; 2.2.1.1 Vinblastine (VLB, 1); 2.2.1.2 Vincristine (VCR, 2); 2.2.1.3 Vindesine (VDS, 3)2.2.1.4 Vinorelbine (VRLB, 4); 2.2.1.5 Vinflunine (VFL, 5); 2.2.2 Camptothecin and Analogs; 2.2.2.1 Camptothecin (CPT, 6); 2.2.2.2 Irinotecan (CPT-11); 2.2.2.3 Topotecan; 2.2.2.4 Exatecan; 2.2.2.5 Gimatecan; 2.2.2.6 Karenitecin; 2.2.2.7 Lurtotecan; 2.2.2.8 Rubitecan (9-nitrocamptothecin); 2.2.3 Taxanes; 2.2.3.1 Paclitaxel; 2.2.3.2 Docetaxel; 2.3 Antitumor Alkaloids in Clinical ; Trials; 2.3.1 Ecteinascidin-743 (Yondelis, Trabectedin); 2.3.2 7-Hydroxystaurosporine (UCN-01); 2.3.3 Ellipticine and Analogs; 2.3.4 Acronycine and Analogs; 2.3.5 Colchicine and Analogs; 2.3.6 Ukrain2.4 Alkaloids Used for MDR Reversal; 2.4.1 Cinchona Alkaloids; 2.4.2 Dofequidar Fumarate (MS-209); 2.5 Alkaloids Used for Cancer Prevention; 2.6 Conclusions; 2.7 Acknowledgments; 3 Alkaloids and the Bitter Taste; 3.1 Introduction; 3.2 The Bitter Taste Chemoreception Mechanism; 3.3 Bitter Alkaloids in Food; 3.4 The Bitter Taste of Alkaloids in Other Drugs and Poisons; 3.5 Alkaloids and Taste in Insects; 3.6 The Bitter Taste of Alkaloids: Should We Avoid, Mask, or Understand?; 3.7 Acknowledgments; 4 Capsaicin and Capsaicinoids; 4.1 Introduction; 4.2 What Is an Alkaloid? Is Capsaicin an Alkaloid?4.3 Diversity, Biosynthesis, and Metabolism of Capsaicinoids; 4.4 Quantization of Capsaicinoids and Their Distribution in Chili Pepper; 4.5 Isolation and Synthesis of Capsaicin; 4.6 TRV1 as the Biological Target of Capsaicin and the Ecological Raison d'être of Capsaicinoids: A Molecular View; 4.7 Naturally Occurring Analogs and Antagonists of Capsaicin and Endogenous Vanilloids; 4.8 Structure-Activity Relationships of Capsaicinoids; 4.9 Molecular Gastronomy of Hot Food; 4.9.1 Biomedical Relevance of Capsaicin-Induced Trigeminal Responses; 4.9.2 Effect of Capsaicin on Taste4.9.3 Gustatory Sweating; 4.9.4 Gustatory Rhinitis; 4.9.5 Hot Food Mitridatism; 4.9.6 Effect of Capsaicin on Digestion; 4.9.7 Capsaicin and Stomach Cancer; 4.9.8 The Effect of Age and Sex on the Sensitivity to Capsaicin; 4.9.9 Capsaicin as a Slimming Agent; 4.9.10 Quenching Capsaicin; 4.9.11 Chilies and Olive Oil; 4.9.12 Who Should Avoid Chilies?; 4.9.13 How can the Pungency of Chilies be Moderated?; 4.9.14 Psychology of Pepper Consumption; 4.10 Conclusions; 4.11 Acknowledgments; 5 Glycosidase-Inhibiting Alkaloids: Isolation, Structure, and Application; 5.1 Introduction
• Sommario/riassunto: This book presents all important aspects of modern alkaloid chemistry, making it the only work of its kind to offer up-to-date and comprehensive coverage. While the first part concentrates on the structure and biology of bioactive alkaloids, the second one analyzes new trends in alkaloid isolation and structure elucidation, as well as in alkaloid synthesis and biosynthesis.A must for biochemists, organic, natural products, and medicinal chemists, as well as pharmacologists, pharmaceutists, and those working in the pharmaceutical industry.

Extratemporal lobe epilepsy surgery / / Mohamad Z. Koubeissi and Robert J. Maciunas

• Record Nr.: UNINA9910965043803321
• Autore: Koubeissi Mohamad Z
• Pubbl/distr/stampa: Montrouge, France, : John Libbey Eurotext, 2011
• ISBN: 9782742011803; 2742011803
• Descrizione fisica: 1 online resource (529 p.)
• Collana: Progress in epileptic disorders / International Epilepsy Colloquium-Clevland, , 1777-4284 ; ; v. 10
• Altri autori (Persone): MaciunasRobert J
• Disciplina: 616.853
• Soggetti: Epilepsy - Surgery; Epileptics
• Lingua di pubblicazione: Inglese
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Note generali: Description based upon print version of record.
• Nota di bibliografia: Includes bibliographical references.
• Nota di contenuto: section 1. Semiology of extratemporal epilepsy -- section 2. Non-invasive neurophysiology of extratemporal lobe epilepsies -- section 3. Neuroimaging of extra temporal lobe epilepsies -- section 4. Invasive evaluation of extratemporal lobe epilepsies -- section 5. Surgery and outcome of extratemporal lobe epilepsies.
• Sommario/riassunto: The theme of the Cleveland colloquium which took place in May 2010 was extratemporal lobe epilepsy surgery. Patients with refractory extratemporal lobe epilepsy, particularly those in whom imaging examinations did not reveal any brain lesions, have a less positive prognosis after surgery than those with mesial temporal lobe epilepsy. The semiology of seizures, the functional imaging techniques, neuropsychological evaluation and intracranial EEG are used to select surgical patients. Moreover, a large number of centres have experimented with new methods for identifying the epileptogenic area in these patients. This work outlines diagnostic and prognostic tools available as well as epilepsy surgery. Written by international experts who attended the Cleveland colloquium, it will be all the more useful to neurologists, neurosurgeons and epileptologists as no other work until now has focused on this subject.