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1. |
Record Nr. |
UNINA9910155281303321 |
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Autore |
Manninen V |
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Titolo |
Sudden Coronary Death : : 4th Paavo Nurmi Symposium, Helsinki, September 1977: Proceedings / / editors, V. Manninen, P.I. Halonen |
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Pubbl/distr/stampa |
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Basel : , : S. Karger, , 1978 |
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ISBN |
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Edizione |
[1st ed.] |
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Descrizione fisica |
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1 online resource (VIII + 232 pages) : : 54 figures, 41 tables |
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Collana |
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Advances in Cardiology, , 1662-2839 ; ; Vol.25 |
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Altri autori (Persone) |
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ManninenVesa |
HalonenPentti I |
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Disciplina |
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Soggetti |
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Cardiovascular System |
Cytology |
Metabolism |
Pathology |
Pharmaceutics |
Pharmacology |
Preventive Medicine |
Social Medicine |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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2. |
Record Nr. |
UNINA9910963970003321 |
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Titolo |
Kallikrein-related peptidases . Volume 1 Characterization, regulation, and interactions within the protease web / / Viktor Magdolen ... [et al.], editors |
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Pubbl/distr/stampa |
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Berlin, : Walter de Gruyter, c2012 |
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ISBN |
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Edizione |
[1st ed.] |
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Descrizione fisica |
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1 online resource (428 p.) |
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Collana |
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Kallikrein-related peptidases ; ; Volume 1 |
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Classificazione |
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Altri autori (Persone) |
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Disciplina |
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Soggetti |
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Kallikrein - Genetics |
Kallikrein - Metabolism |
Tumors - Genetics |
Proteolytic enzymes - Metabolism |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references and index. |
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Nota di contenuto |
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Genomic structure of the KLK locus -- Single nucleotide polymorphisms in the human KLK locus and their implication in various diseases -- Evolution of Kallikrein-related peptidases -- Structural aspects of Kallikrein-related peptidases -- Molecular recognition properties of Kallikrein-related peptidases on synthetic and endogenous substrates -- Natural, engineered, and synthetic inhibitors of Kallikrein-related peptidases -- Kallikrein-related peptidases as pharmaceutical targets -- Expression of Kallikrein-related peptidases under (patho) physiological conditions -- Kallikrein-related peptidases within the proteolytic web -- Kallikrein-Kinin cascade: bioregulation by human tissue kallikrein 1 (HK1, KLK 1) -- Role of KLK4 in dental enamel formation. |
Kallikrein-related peptidases and semen -- Kallikrein-related peptidases and inhibitors of the skin -- Physiological and pathophysiological roles of Kallikrein-related peptidases in the central nervous system -- Kallikrein-related peptidases (KLKS), proteinase-mediated signaling and proteinase-activated receptors (PARS) -- Pathophysiology of Kallikrein-related peptidases in lung cancer -- |
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Clinical relevance of Kallikrein-related peptidases in gastric and colorectal cancer -- Pathophysiology of Kallikrein-related peptidases in head and neck cancer -- PSA (prostate-specific antigen) and other Kallikrein-related peptidases in prostate cancer -- Cellular model systems to study the tumor biological role of Kallikrein-related peptidases in ovarian and prostate cancer -- Clinical relevance of Kallikrein-related peptidases in breast cancer -- Clinical relevance of Kallikrein-related peptidases in ovarian cancer -- MicroRNAs : a new control mechanism for Kallikrein-related peptidases in kidney and other cancers -- Genomic instability of the KLK-locus in cancer -- Kallikrein-related peptidases as biomarkers in personalized cancer medicine. |
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Sommario/riassunto |
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This handbook is the first comprehensive book of its kind reviewing the clinically relevant current status of tissue kallikrein and kallikrein-related peptidases research. Since several members of the KLK family are key players in (patho-)physiological processes, structural, functional, and regulatory studies are under way to develop new strategies to prevent and treat disorders to which individual members of the KLK protease family contribute significantly. The goal of this book is to inform clinicians, physician scientists and researchers about the prominent role of the multifaceted and interactive KLK system in normal physiology and pathological organ function. |
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3. |
Record Nr. |
UNINA9910975149303321 |
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Titolo |
Demarketing / / edited by Nigel Bradley and Jim Blythe |
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Pubbl/distr/stampa |
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Abingdon, Oxon : , : Routledge, , 2014 |
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ISBN |
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0-415-81648-3 |
0-203-59120-8 |
1-135-07041-5 |
1-135-07042-3 |
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Edizione |
[1st ed.] |
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Descrizione fisica |
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1 online resource (445 p.) |
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Altri autori (Persone) |
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BlytheJim |
BradleyNigel <1958-> |
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Disciplina |
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Soggetti |
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Marketing - Management |
Marketing |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references and index. |
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Nota di contenuto |
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Cover; Half Title; Title Page; Copyright Page; Dedication; Table of Contents; List of tables and figures; Acknowledgments; Contributors; 1. Demarketing: an overview of the antecedents and current status of the discipline; 2. Synchromarketing; 3. Synchromarketing: demarketing places; 4. Countermarketing in a wicked problem context - the case of cocaine; 5. Counter-marketing case studies; 6. General demarketing; 7. General demarketing case study; 8. Selective demarketing: a value destruction approach; 9. Selective demarketing: case study - Frizzell Insurance |
10. Ostensible demarketing: the power of prohibition11. Ostensible demarketing case study; 12. Unintentional demarketing; 13. "Unintentional demarketing" in higher education; 14. Demarketing and marketing: a conceptual discussion; Index |
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Sommario/riassunto |
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<P>We all understand the basic principles underpinning marketing activity: to identify unfulfilled needs and desires and boost demand for the solutions a product is offering. The mantra is always ""sell more"". De-marketing tries for the very opposite. Why would a company actively try to decrease demand?</P><P>There are many good reasons to do so: a firm cannot supply large enough quantities, or |
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wants to limit supply to a region of narrow profit margin. Or, crucially, to discourage undesirable customers: those that could be bad for brand reputation, or in the case of the finance sector, high r |
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