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Record Nr. |
UNINA9910963356103321 |
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Autore |
Robinson Joseph D. |
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Titolo |
Mechanisms of synaptic transmission : bridging the gaps (1890-1990) / / Joseph D. Robinson |
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Pubbl/distr/stampa |
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Oxford ; ; New York, : Oxford University Press, 2001 |
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ISBN |
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0-19-803145-9 |
9786610834624 |
1-280-83462-5 |
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Descrizione fisica |
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1 online resource (xiv, 451 pages) : illustrations |
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Disciplina |
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Soggetti |
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Neural transmission - Research - History - 20th century |
Synapses - Research - History - 20th century |
Synaptic Transmission - physiology |
Research - history |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references (p. 359-442) and index. |
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Nota di contenuto |
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Contents; 1. Beginnings: Cajal and the Neuron Theory (1889-1909); Cajal at Berlin; Background: Cells, Nerve Cells, and Nerve Impulses; Proclamation of the Neuron Theory; Cajal's Contributions; Confirmations, Criticisms, and Responses; Conclusions; 2. Beginnings: Sherrington and the Synapse (1890-1913); Sherrington, Reflexes, and the Synapse; Background: Reflexes; Sherrington's Achievements; Synapses and the Reflex Arc; Conclusions; 3. Chemical Transmission at Synapses (1895-1945); Nerve Impulse Conduction and Synapse Structure; Background: The Autonomic Nervous System |
Chemical Transmission in the Autonomic Nervous SystemChemical Transmission at Neuromuscular Junctions; Chemical Transmission in the Central Nervous System; Electrical Transmission; Conclusions; 4. Chemical Transmission at Synapses (1945-1965); Postwar Progress; Identifying Chemical Transmission; Visualizing Synaptic Gaps and Synaptic Vesicles; Identifying Electrical Transmission; Conclusions; 5. Identifying Neurotransmitters (1946-1976); Scope and Criteria; |
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Acetylcholine; Noradrenaline; Dopamine; Serotonin; GABA; Glutamate; Glycine; Neuropeptides: Substance P and Enkephalins; Conclusions |
6. Characterizing Receptors (1905-1983)Essential Issues; Drug-Receptor Interactions; Receptor Classification; Structure-Activity Relationships; Receptor Identification and Purification; Responses of Individual Receptor Molecules; Conclusions; 7. Second Messengers (1951-1990); Cyclic AMP; Protein Kinases and Phosphatases; G-Proteins; Ca[sup(2+)]; Inositol-trisphosphate and Diacylglycerol; Conclusions; 8. Receptor Structures and Receptor Families (1983-1990); Molecular Biology and Recombinant DNA Techniques; Nicotinic Cholinergic Receptors; Ligand-Gated Ion Channels; Adrenergic Receptors |
G-Protein Coupled ReceptorsReceptor Regulation; Conclusions; 9. Synthesis, Storage, Transport, and Metabolic Degradation of Neurotransmitters; Steps in Chemical Transmission; Synthesis; Storage; Degradation; Transport (""Reuptake""); Conclusions; 10. Neurotransmitter Release; Proposals; Evidence for Exocytotic Release; Triggering of Release; Mechanism of Release; Endocytotic Retrieval of Vesicles; Ca[sup(2+)]-Independent Non-Exocytotic Release; Conclusions; 11. Formation of Specific Synapses; Embryonic Development of Synaptic Connections; Approaches and Possible Mechanisms |
Early Arguments Concerning Chemotaxis (1890-1963)Cell Death and Neurotrophic Factors; Chemical Guidance (1963-1990); Growth Cone Motility; Synapse Formation; Conclusions; 12. Learning; Background; Chemical Representations; Learning in Aplysia; Learning in Drosophila; Learning in Mammals: The Hippocampus and Long-Term Potentiation (LTP); Conclusions; 13. Diseases and Therapies; Defining and Developing; Parkinson's Disease; Schizophrenia; Depression and Manic-Depressive Illness; Conclusions; 14. Epilogue; Progress; Historical Accounts and Conclusions; Assumptions; Approaches; Goals |
Generalities and Exceptions |
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Sommario/riassunto |
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This book describes a century of research on how nerve cells communicate with one another, beginning with the formulation of the Neuron Theory and proceeding through studies embracing a broad range of disciplines. The Neuron Theory initially depicted discrete nerve cells interacting at their points of contact (""synapses""); since nerve impulse were often indentified as electrical signals traveling along neuronal processes, it seemed plausible that impulses would also pass from cell to electrically. Over the next hundred years, however, ingenious experiments, facilitated by powerful new techni |
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