Molecular aspects of infectious disease / / Mazen T. Saleh, editor

• Record Nr.: UNINA9910956822103321
• Pubbl/distr/stampa: New York, : Nova Science Publishers, c2011
• ISBN: 1-61761-251-0
• Edizione: [1st ed.]
• Descrizione fisica: 1 online resource (214 p.)
• Collana: Immunology and immune system disorders; Nova biomedical
• Altri autori (Persone): SalehMazen T
• Disciplina: 616.9/0471
• Soggetti: Molecular microbiology; Communicable diseases - Molecular aspects; Pathology, Molecular
• Lingua di pubblicazione: Inglese
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Note generali: Description based upon print version of record.
• Nota di bibliografia: Includes bibliographical references and index.
• Nota di contenuto: Intro -- MOLECULAR ASPECTS OF INFECTIOUS DISEASE -- MOLECULAR ASPECTS OF INFECTIOUS DISEASE -- Library of Congress Cataloging-in-Publication Data -- Contents -- Chapter I Overview -- Epidemiology -- Host-Pathogen Interaction -- Emerging Infectious Diseases -- Chapter II Structure and Function of Bacterial and Fungal Cell Walls -- Bacterial Cell Walls -- Gram-Positive Cell Walls -- Mycobacterial Cell Walls -- Gram-Negative Cell Walls -- Fungal Cell Walls -- Conclusion -- References -- Chapter III Bacterial Cell Surface Structures Important in Pathogenesis -- Importance of the Bacterial Cell Surface -- Bacterial Capsules and Slime Layers -- S-Layers -- References -- Chapter IV An Introduction to Protein Secretion in Prokaryotes -- Type I Secretion System (T1ss) -- Architecture -- Mechanism of Transport -- Protein Folding -- Summary -- Type II Secretion System (T2ss) -- General Secretory Pathway (Gsp) -- Architecture -- Mechanism of Transport -- Protein Folding -- Twin Arginine Translocation (Tat) Pathway -- Architecture -- Mechanism of Transport -- Outer Membrane Transport -- Summary -- Type III Secretion System (T3ss) -- Architecture -- Mechanism of Transport -- Summary -- Type IV Secretion System (T4ss) -- Architecture -- Mechanism of Transport -- Summary -- Type V Secretion System (T5ss) -- Autotransporters (Va) -- Two-Partner Secretion (Vb) -- ; Oligomeric Coiled-Coil Adhesins (Vc) -- Summary -- Type VI Secretion System (T6ss) -- Architecture and Mechanism of Transport -- Summary -- Type VII Secretion System (T7ss) -- Architecture and Mechanism of Transport -- Summary -- Conclusion -- References -- Chapter V Viruses -- Basic Structure -- The Viral Lifecycle within Host Cells -- Survey of Medically Important Viruses -- Therapeutic Strategies -- References -- Chapter VI The Innate Immune System -- Abstract -- 1. General Description.; 2. Nature of the Innate Immune System Repertoire -- 3. Mechanisms of Recognition by the Innate System - Receptor-Specific Responses -- I. Secreted PRR -- II. Cytoplasmic PRR -- III. Cell Surface Receptors -- Toll-Like Receptors -- 4. Cell Types and Processes Involved in the Innate Immune System -- I. Innate Barriers to Infection -- II. Innate Immune Cells -- II. Innate Immune Cells -- IV. Cytokine and Chemokine Production -- 5. Inflammatory Responses -- 6. Antigen Processing - Role of Innate Immunity in Stimulating Adaptive Immune Responses -- 7. Disorders of the Innate Immune System -- References -- Chapter VII Respiratory Infections -- Abstract -- Introduction -- Pulmonary Infections -- Streptococcus Pneumoniae -- Colonization of Upper Airways -- Invasion and Dissemination -- Immune Defense and Inflammation -- Immune Evasion -- PSEUDOMONAS AERUGINOSA -- Clinical Significance -- Pseudomonas Aeruginosa in CF -- Mechanisms of Microbial Pathogenesis -- Apoptosis of Host Cells Caused by Pseudomonas Aeruginosa -- Molecular Mechanisms of Inflammation Caused by Pseudomonas Aeruginosa Infection -- The Role of Airway Epithelial Cells in the Pathogenesis of Pseudomonas Aeruginosa Pulmonary Infections -- Immune Evasion -- Conclusion -- References -- Chapter VIII Prions -- Abstract -- Introduction -- Infectious but Proteinaceous Pathogens -- Isolation of Infectious Agents Composed of Proteins only -- Identification of Prp Gene -- Protein-only Hypothesis -- Isoforms of Prion Protein: PrPc and PrPsc -- PrPc Function in Physiology and Prion Pathogenesis -- Structure of PrPc and PrPsc -- Models of PrPsc Aggregates -- Prion Replication -- Conclusion -- Acknowledgments -- References -- Chapter IX Transmissible Spongiform Encephalopathy (TSE) -- Abstract -- Introduction -- Transmission of TSEs -- Species Barrier -- Prion Strain -- Prion Pathogenesis.; TSEs in Humans and Animals -- Clinical and Pathological Features -- Human TSEs -- Idiopathic TSEs: sCJD and Sporadic Fatal Insomnia -- Inherited TSEs: fCJD, GSS and FFI -- Acquired TSEs: kuru, iCJD, and vCJD -- Animal TSes -- Scrapie -- BSE -- CWD -- Other Animal TSEs -- Conclusion -- Acknowledgments -- References -- Chapter X Diagnostic Microbiology -- Abstract -- Introduction -- Direct Examination and Antigen Testing -- Microscopic Examination -- Common Stain Methods -- Biochemical and Antigen Testing -- Microorganism and Virus Culture -- Primary Alive Culture -- Culture using Living Cells -- Immunological Diagnosis -- Immunofluorescence Methods -- Enzyme Immunoassays -- Immunoblotting -- Other Serologic Techniques -- Molecular Diagnosis -- Nucleic Acid Extraction -- Non-Amplified Probe Methods -- Amplification Methods -- Signal Amplification -- PCR-Target Amplification -- Real Time PCR -- Post Amplification Analyses -- Colorimetric ELISA -- Reverse Hybridization -- Solid Nucleic Acid Arrays -- Suspension Array Analysis -- Sequencing -- Conclusion -- Acknowledgments -- References -- Index.
• Sommario/riassunto: This book contains material relevant for students and researchers interested in the basic science of infectious diseases. The material in this book is organized into three major sections. The first describes the ; structures of various pathogenic microbes. The emphasis in this section is on the surface structures as they mediate the critical step of adsorption of pathogens to their target host cells. There is also a subsection on protein secretion in bacteria. The second section reviews the basics of innate immunity as these are the first line of immune defense and are important to understand the immunological response and its consequences on the health status and physiological balance in the host. The third section provides a description of a number of infectious diseases, particularly those of the respiratory system and prion-related infections.