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1. |
Record Nr. |
UNINA9910954517203321 |
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Titolo |
Responsible research with biological select agents and toxins / / Committee on Laboratory Security and Personnel Reliability Assurance Systems for Laboratories Conducting Research on Biological Select Agents and Toxins, Board on Life Sciences, Division on Earth and Life Studies, National Research Council of the National Academies |
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Pubbl/distr/stampa |
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Washington, D.C., : National Academies Press, c2009 |
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ISBN |
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9786612554629 |
9780309150293 |
0309150299 |
9781282554627 |
128255462X |
9780309145367 |
0309145368 |
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Edizione |
[1st ed.] |
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Descrizione fisica |
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1 online resource (188 p.) |
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Disciplina |
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Soggetti |
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Biological laboratories - Security measures - United States |
Biological laboratories - United States - Safety measures |
Biological weapons |
Biology - Research - Standards |
Bioterrorism - Safety measures |
Hazardous substances |
Laboratories - Security measures - United States |
Microbiological laboratories - Security measures - United States |
Microbiological laboratories - United States - Safety measures |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references (p. 135-141). |
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Nota di contenuto |
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""Front Matter""; ""Preface""; ""Acknowledgments""; ""Contents""; ""Executive Summary""; ""Summary""; ""1 Introduction""; ""2 The Current Regulatory Environment""; ""3 Guiding Principles for Science and Security""; ""4 Issues Related to Personnel Reliability""; ""5 Managing BSAT Research and the Select Agent Program""; ""References""; |
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""Appendixes""; ""Appendix A: Committee Member and Staff Biographies""; ""Appendix B: Information on Briefings and Site Visits""; ""Appendix C: Abbreviations and Acronyms""; ""Appendix D: Application for Security Risk Assessment"" |
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Sommario/riassunto |
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The effort to understand and combat infectious diseases has, during the centuries, produced many key advances in science and medicine--including the development of vaccines, drugs, and other treatments. A subset of this research is conducted with agents that, like anthrax, not only pose a severe threat to the health of humans, plants, and animals but can also be used for ill-intended purposes. Such agents have been listed by the government as biological select agents and toxins. The 2001 anthrax letter attacks prompted the creation of new regulations aimed at increasing security for research with dangerous pathogens. The outcome of the anthrax letter investigation has raised concern about whether these measures are adequate. Responsible Research with Biological Select Agents and Toxins evaluates both the physical security of select agent laboratories and personnel reliability measures designed to ensure the trustworthiness of those with access to biological select agents and toxins. The book offers a set of guiding principles and recommended changes to minimize security risk and facilitate the productivity of research. The book recommends fostering a culture of trust and responsibility in the laboratory, engaging the community in oversight of the Select Agent Program, and enhancing the operation of the Select Agent Program. |
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2. |
Record Nr. |
UNINA9910969824303321 |
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Titolo |
Global view of the fight against influenza / / Petar M. Mitrasinovic, editor |
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Pubbl/distr/stampa |
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New York, : Nova Science Publishers, 2009 |
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ISBN |
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Edizione |
[1st ed.] |
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Descrizione fisica |
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1 online resource (442 p.) |
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Altri autori (Persone) |
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MitrasinovicPetar M. <1968-> |
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Disciplina |
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Soggetti |
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Influenza - Prevention |
Influenza |
Influenza - Epidemiology |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references and index. |
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Nota di contenuto |
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1. William Graeme Laver (Graeme) Ph.D. frs 1929-2008 / Robert G. Webster -- 2. The origin and control of pandemic influenza / the abstract and first section - the late W. Graeme Laver ; Penny G. Laver and Adrian J. Gibbs -- 3. Flu drugs : pathway to discovery / William Graeme Laver -- 4. Advances in molecular evolution of influenza a virus / Xiu-Feng Wan and Michael Emch -- 5. Pathogenesis of avian influenza (h5n1) infection in humans / Ruishu Deng and Jiang Gu -- 6. The interactions between avian h5n1 influenza virus and dendritic cell-specific icam-3 grabbing non-integrin (dc-sign) / Sheng-Fan Wang and Yi-Ming Arthur Chen -- 7. The activity of neuraminidase inhibitor oseltamivir against all subtypes of influenza viruses / Noel A. Roberts and Elena A. Govorkova -- 8. Computational investigations of the binding mechanism of current influenza virus neuraminidase inhibitors: correlation with experiment / Marija L. Mihajlovic and Petar M. Mitrasinovic -- 9. The impact of structural biology on the understanding of the influenza virus and the rational design of antivirals / Philip S. Kerry and Rupert J. Russell -- 10. The structure-based design of novel inhibitors of h5n1 virus neuraminidase / Petar M. Mitrasinovic -- 11. On the development of vaccines against pandemic influenza / Petar M. Mitrasinovic -- 12. Alternative strategies for vaccine development against avian flu / Michele A. Zacks and Slobodan Paessler -- 13. Advances in quantitative analyses of the hemagglutinin |
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of influenza a viruses and vaccines / Xuguang Li, Terry D. Cyr, Michel Girard, Changgui Li, Junzi Wang, Gary Van Domselaar, Aaron Farnsworth, Helen Macdonald-Piquard, and Runtao He -- 14. Niaid resources for the global research community to support development of new influenza therapeutics / Amy Krafft, Rachelle Salomon, and Martin Crumrine -- 15. Micronutrients in the global fight against influenza / Raxit J. Jariwalla, M. Waheed Roomi, Tatiana Kalinovsky, Matthias Rath, and Aleksandra Niedzwiecki -- 16. The ikarus syndrome in the poultry industry and the concern about a new great influenza pandemic : what to learn from Ikarus' crash / Sievert Lorenzen -- 17. Theoretical aspect of prevention policies against influenza pandemic / Shingo Iwami, Yasuhiro Takeuchi, Xianning Liu, Andrei Korobeinikov, Eunok Jung, and Tae-Chang Jo -- 18. The impact of an emerging avian influenza virus (h5n1) in a seabird colony / Suzanne M. O'Regan, Tom C. Kelly, Andrei Korobeinikov, Michael J.A. O'Callaghan, and Alexei V. Pokrovskii -- 19. Control of influenza at healthcare facilities in resource-limited settings / Thana Khawcharoenporn, Anucha Apisarnthanarak, and Linda M. Mundy -- 20. Between panic and apathy : the fight against influenza in South Africa / Thomas Gstraunthaler. |
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Sommario/riassunto |
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Influenza has become an important infectious disease with regard to its enormous clinical and economic impact on population health. This book indicates the future directions in which the war versus influenza is to be developed, thus ensuring its scientific priority. It is suitable for health care professionals and health science administrators. |
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