1.

Record Nr.

UNINA9910144700003321

Autore

Symposium CIBA Foundation

Titolo

Ageing in transient tissues [[electronic resource] /] / editors for the Ciba Foundation, G.E.W. Wolstenholme and Elaine C.P. Millar

Pubbl/distr/stampa

London, : J. & A. Churchill, 1956

ISBN

1-280-76857-6

9786613679345

0-470-71898-6

0-470-71643-6

Descrizione fisica

1 online resource (302 p.)

Collana

Ciba Foundation colloquia on ageing ; ; v. 2

Altri autori (Persone)

WolstenholmeG. E. W (Gordon Ethelbert Ward)

MillarElaine C. P

Disciplina

612.67

Soggetti

Aging

Animals - Growth

Placenta

Reproduction

Electronic books.

Lingua di pubblicazione

Inglese

Formato

Materiale a stampa

Livello bibliografico

Monografia

Note generali

Description based upon print version of record.

Nota di bibliografia

Includes bibliographical references and indexes.

Nota di contenuto

CIBA FOUNDATION COLLOQUIA ON AGEING VOLUME 2; CONTENTS; Chairman's opening remarks; Organ culture studies of foetal rat reproductive tracts; Discussion; The age factor in some prenatal endocrine events; Discussion; The regenerative capacity of ovarian tissue; Discussion; The history and fate of redundant follicles; Discussion; The corpus luteum of the guinea pig; Discussion; Observations on the cytomorphosis of the germinal and interstitial cells of the human testis; Discussion; Mitochondrial changes in different physiological states; Discussion

Morphological aspects of ageing in the placentaDiscussion; Chronological changes in placental function; Discussion; Biochemical evidence of ageing in the placenta; Discussion; Uptake of radio-potassium (42K) by the uterus and placenta during the advancement of pregnancy in the rat and the goat; Discussion; Modifications in the foetal development of the rat after administration of growth hormone



or cortisone to the mother; Discussion; The growth cycle of deer antlers; Discussion; Ageing of the axillary apocrine sweat glands in the human female; Discussion; The metabolism of senescent leaves

DiscussionThe physical instability of human red blood cells and its possible importance in their senescence; Ageing in human red cells; Discussion; General Discussion

2.

Record Nr.

UNINA9910954385003321

Autore

Miteva Maria A

Titolo

In silico lead discovery / / by Maria A. Miteva

Pubbl/distr/stampa

[Saif Zone, Sharjah, United Arab Emirates], : Bentham Science Publishers Ltd., [2011]

ISBN

9781608051427

1608051420

Edizione

[1st ed.]

Descrizione fisica

1 online resource (201 p.)

Disciplina

615/.19

Soggetti

Drug development

Drug development - Computer simulation

Lingua di pubblicazione

Inglese

Formato

Materiale a stampa

Livello bibliografico

Monografia

Note generali

Description based upon print version of record.

Nota di bibliografia

Includes bibliographical references and index.

Nota di contenuto

01 Title.pdf; 02 Cover Page; 03 eBooks End User License Agreement-Website; 04 Content; 05 Foreword_Grigirov; 06 Preface_Miteva; 07 Contributors_Proposal_forEbook-MariaMiteva; 08 Chapter 1 Lagorce_et al_revised 2; 09 Chapter 2 Sperandio_et al_revised 2; 10 Chapter 3 Guyon_Tuffery_corrected 2; 11 Chapter 4 Todorov_corrected 2; 12 Chapter 5 Alexov_revised 2; 13 Chapter 6 Miteva_revised 2; 14 Chapter 7 Roche-revised 2; 15 Chapter 8 Pajeva_Wiese_revised 2; 16 Chapter 9 Moro_revised 2; 17 Chapter 10 Lee; 18 Index

Sommario/riassunto

Computer-aided drug design and in silico screening have contributed to the discovery of several compounds that have either reached the market or entered clinical trials. In silico Lead Discovery is a compilation of the efforts of several experts on bioinformatics and drug design in developing the latest advances of in silico approaches for lead discovery. It contains an overview of structure-based, ligand-based methods and current fragment-based methods as well as



examples for successful applications of such methods in discovering new hit/lead molecules for important therapeutic targets. Treat