| |
|
|
|
|
|
|
|
|
1. |
Record Nr. |
UNINA9910953146603321 |
|
|
Titolo |
Preclinical development handbook ADME and biopharmaceutical properties / / [edited by] Shayne Cox Gad |
|
|
|
|
|
|
|
Pubbl/distr/stampa |
|
|
Hoboken, N.J., : Wiley-Interscience, c2008 |
|
|
|
|
|
|
|
ISBN |
|
9786611237417 |
9781281237415 |
1281237418 |
9780470249031 |
047024903X |
9780470249024 |
0470249021 |
|
|
|
|
|
|
|
|
Edizione |
[1st ed.] |
|
|
|
|
|
Descrizione fisica |
|
1 online resource (1347 p.) |
|
|
|
|
|
|
Collana |
|
Pharmaceutical Development Series ; ; v.3 |
|
|
|
|
|
|
Altri autori (Persone) |
|
|
|
|
|
|
Disciplina |
|
|
|
|
|
|
|
|
Soggetti |
|
Pharmacokinetics |
Drug development |
|
|
|
|
|
|
|
|
Lingua di pubblicazione |
|
|
|
|
|
|
Formato |
Materiale a stampa |
|
|
|
|
|
Livello bibliografico |
Monografia |
|
|
|
|
|
Note generali |
|
Description based upon print version of record. |
|
|
|
|
|
|
Nota di bibliografia |
|
Includes bibliographical references and index. |
|
|
|
|
|
|
Nota di contenuto |
|
PRECLINICAL DEVELOPMENT HANDBOOK ADME and Biopharmaceutical Properties; CONTRIBUTORS; CONTENTS; Preface; 1 Modeling and Informatics in Drug Design; 2 Computer Techniques: Identifying Similarities Between Small Molecules; 3 Protein-Protein Interactions; 4 Method Development for Preclinical Bioanalytical Support; 5 Analytical Chemistry Methods: Developments and Validation; 6 Chemical and Physical Characterizations of Potential New Chemical Entity; 7 Permeability Assessment; 8 How and Where Are Drugs Absorbed?; 9 Absorption of Drugs after Oral Administration |
10 Distribution: Movement of Drugs through the Body11 The Blood-Brain Barrier and Its Effect on Absorption and Distribution; 12 Transporter Interactions in the ADME Pathway of Drugs; 13 Accumulation of Drugs in Tissues; 14 Salt and Cocrystal Form Selection; 15 Dissolution; 16 Stability: Physical and Chemical; 17 Dosage |
|
|
|
|
|
|
|
|
|
|
|
Formulation; 18 Cytochrome P450 Enzymes; 19 Metabolism Kinetics; 20 Drug Clearance; 21 In Vitro Metabolism in Preclinical Drug Development; 22 Utilization of In Vitro Cytochrome P450 Inhibition Data for Projecting Clinical Drug-Drug Interactions |
23 In Vivo Metabolism in Preclinical Drug Development24 In Vitro Evaluation of Metabolic Drug-Drug Interactions: Scientific Concepts and Practical Considerations; 25 Mechanisms and Consequences of Drug-Drug Interactions; 26 Species Comparison of Metabolism in Microsomes and Hepatocytes; 27 Metabolite Profiling and Structural Identification; 28 Linkage between Toxicology of Drugs and Metabolism; 29 Allometric Scaling; 30 Interrelationship between Pharmacokinetics and Metabolism; 31 Experimental Design Considerations in Pharmacokinetic Studies; 32 Bioavailability and Bioequivalence Studies |
33 Mass Balance Studies34 Pharmacodynamics; 35 Physiologically Based Pharmacokinetic Modeling; 36 Mathematical Modeling as a New Approach for Improving the Efficacy/Toxicity Profile of Drugs: The Thrombocytopenia Case Study; 37 Regulatory Requirements for INDs/FIH (First in Human) Studies; 38 Data Analysis; Index |
|
|
|
|
|
|
Sommario/riassunto |
|
A clear, straightforward resource to guide you through preclinical drug developmentFollowing this book's step-by-step guidance, you can successfully initiate and complete critical phases of preclinical drug development. The book serves as a basic, comprehensive reference to prioritizing and optimizing leads, dose formulation, ADME, pharmacokinetics, modeling, and regulations. This authoritative, easy-to-use resource covers all the issues that need to be considered and provides detailed instructions for current methods and techniques.Each chapter is written by one or more leadin |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
2. |
Record Nr. |
UNINA9910971552503321 |
|
|
Autore |
Tangwa Godfrey B |
|
|
Titolo |
Road companion to democracy and meritocracy : (further essays from an African perspective) / / Godfrey B. Tangwa |
|
|
|
|
|
|
|
Pubbl/distr/stampa |
|
|
Mankon, Bamenda, Cameroon, : Langaa Research & Pub. CIG, 2010 |
|
|
|
|
|
|
|
ISBN |
|
1-282-86919-1 |
9786612869198 |
9956-578-37-1 |
9956-616-84-2 |
9956-616-92-3 |
|
|
|
|
|
|
|
|
Descrizione fisica |
|
1 online resource (264 p.) |
|
|
|
|
|
|
Disciplina |
|
|
|
|
|
|
Soggetti |
|
Democracy - Africa |
Africa Politics and government Philosophy |
Africa Civilization |
|
|
|
|
|
|
|
|
Lingua di pubblicazione |
|
|
|
|
|
|
Formato |
Materiale a stampa |
|
|
|
|
|
Livello bibliografico |
Monografia |
|
|
|
|
|
Note generali |
|
"This book is a follow-up to my Democracy and meritocracy : philosophical essays and talks from an African perspective (Galda + Wilch Verlag, Glienicke-Berlin, 1996)"--P. xiii. |
|
|
|
|
|
|
|
|
Nota di bibliografia |
|
Includes bibliographical references. |
|
|
|
|
|
|
Nota di contenuto |
|
Cover; Title Page; Copyright Page; Content; Dedication; Acknowledgement; Preface; Part One; 1. Democracy and Development in Africa: Putting the Horse before the Cart; 2. The Medium and Long Term Lessons of the Lake Nyos Natural Disaster; 3. X For All by the Year 2000; 4. Letter to the Dean; 5. Fonlon's Socratic Life: Its Relevance to our Political Culture and Contemporary Situation; 6. The Sasse Motto Fide Quaerens Intellectum; 7. The Plight of the Ex-seminarian and Ex-religious in Modern Cameroon; 8. Bernard Fonlon Evening Monday 19th November 1990; 9. Fale Wache, Lament of a Mother |
10. On The Television Programme "The Debate"11. Is There Really an Anglophone Problem in Cameroon?; 12. The Beginning of the End; 13. Our Book of Revelations; 14. Cameroonians are Unshockable; 15. From Unshockability to Exaggerated Credulity; 16. For the Attention of my Students; 17. Revelations Chapter 3; 18. Our Mungo Bridges; Part Two. In the Spirit of GOBATA; 1. The Stuff Mandela is Made of; 2. Of Prof |
|
|
|
|
|
|
|
|
|
|
|
Ngwafor's Practical Jealousy and Ambition's Sterner Stuff; 3. Struggling Non-violently: The Case of the SCNC; 4. Western Democracies and African Dictatorships |
5. Western Democracies and African Dictatorships6. Tenth Anniversary of a Horrible Year; 7. Where we Should Be Heading; 8. In the Spirit of a Zealous Disciple; 9. A Rich Harvest of Peters by Paul; 10. The Collapse of the French Empire in Africa; 11. Between Mvondo and Mvodo; The Emergence of Victor Ayissi; 12. Corruption Fights Cameroon; 13. Rumours of Dangerous Manoeuvres and Machinations; 14. Politics of Back Scratching; 15. For the Attention of All Potential Ethnic Cleansers; 16. Independent Electoral Commission, an Absolute Necessity; 17. How to Demystify John Fru Ndi |
18. If You Saw The Shah Escaping...19. On Behalf of a College Room-mate; 20. Mixed Signals of the Emerging Shape of Things; 21. Address to the Youth; 22. Registering on the Electoral List; 23. In Provisional Praise of Paul Biya; 24. Constitutional Council: Why we Are Worried; 25. For Every Mobutu a Kabila; 26. Killing an Innocent Person Can Never Be Justified; 27. On the Threshold of a Democratic Breakthrough; 28. Yielding Place to a New Order; 29. Mola Njoh Litumbe's Concept of Home; 30. As a Participant Observer; 31. Waiting for Kabila; 32. Kleptocracy and Mendacity as Identification Marks |
33. Non Dimittis, Domine33Non Dimittis, Domine |
|
|
|
|
|
|
Sommario/riassunto |
|
Each of the essays in this book is marked by a certain simplicity and clarity, a seriousness tinged with humour, masking a profundity that are unmistakably characteristic of Godfrey B. Tangwa alias Rodcod Gobata, one of the leading critical minds amongst Cameroonians. The essays are centred on the theme of democracy and meritocracy which the author believes to be the pre-conditions for genuine development in Africa. The immediate focus of these essays is Cameroon, a country remarkable for experimenting with French/English bilingualism and for having a political dictatorship which claims, wrong |
|
|
|
|
|
|
|
| |