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Record Nr. |
UNINA9910143702703321 |
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Titolo |
Mast cells and basophils [[electronic resource] ] : development, activation and roles in allergic/autoimmune disease |
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Pubbl/distr/stampa |
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Chichester, : John Wiley, 2005 |
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ISBN |
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1-280-30875-3 |
9786610308750 |
0-470-03344-4 |
0-470-03051-8 |
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Descrizione fisica |
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1 online resource (275 p.) |
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Collana |
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Novartis Foundation symposium ; ; 271 |
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Altri autori (Persone) |
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Disciplina |
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Soggetti |
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Mast cells |
Basophils |
Electronic books. |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Symposium on mast cells and basophils : development, activation and roles in allergic/autoimmune disease, held at the Novartis Foundation, London, 16-18 November 2004. |
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Nota di bibliografia |
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Includes bibliographical references and indexes. |
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Nota di contenuto |
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MAST CELLS AND BASOPHILS: DEVELOPMENT, ACTIVATION AND ROLES IN ALLERGIC/AUTOIMMUNE DISEASE; Contents; Participants; Chair's introduction; MITF and SgIGSF: an essential transcription factor and its target adhesion molecule for development and survival of mast cells; Discussion; Immune sensitization in the skin is enhanced by antigen-independent effects of IgE on mast cells; Discussion; The role of Src family kinases in mast cell effector function; Discussion; RasGRP4 in mast-cell signalling and disease susceptibility; Discussion |
Regulation of mast cell secretory response to the type I Fce receptor: inhibitory elements and desensitisationDiscussion; General discussion I; IgE regulation of mast cell survival and function; Discussion; RabGEF1, a negative regulator of Ras signalling, mast cell activation and skin inflammation; Discussion; Role of CC chemokines and their receptors in multiple aspects of mast cell biology: comparative protein profiling of FceRI- and/or CCR1-engaged mast cells using protein chip |
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technology; Discussion; The role of phosphoinositide-3-kinase in mast cell homing to the gastrointestinal tract |
DiscussionThe mast cell and the cysteinyl leukotrienes; Discussion; Regulation of gene expression in mast cells: micro-RNA expression and chromatin structural analysis of cytokine genes; Discussion; The involvement of Bcl-2 in mast cell apoptosis; Discussion; General discussion II; General discussion III; Mast cells in autoantibody responses and arthritis; Discussion; MASTering the immune response: mast cells in autoimmunity; Discussion; Mastocytosis; Discussion; Index of contributors; Subject index |
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Sommario/riassunto |
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The book presents recent advances relating to the factors and mechanisms that regulate the growth, differentiation and function of mast cells and basophils; discussion of new technologies used to study these cells, and integration of the basic scientific findings in the context of therapeutic possibilities for the treatment of diseases such as allergic inflammation and autoimmune disease which are mediated, in part, by these granulocytes. |
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2. |
Record Nr. |
UNINA9910903796903321 |
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Autore |
Kämpf Günter |
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Titolo |
Antiseptic Stewardship : Biocide Resistance and Clinical Implications / / by Günter Kampf |
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Pubbl/distr/stampa |
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Cham : , : Springer International Publishing : , : Imprint : Springer, , 2024 |
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ISBN |
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Edizione |
[2nd ed. 2024.] |
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Descrizione fisica |
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1 online resource (1056 pages) |
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Disciplina |
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Soggetti |
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Medical microbiology |
Public health |
Medicine - Research |
Biology - Research |
Bacteria |
Environmental health |
Medical Microbiology |
Public Health |
Biomedical Research |
Environmental Health |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Nota di contenuto |
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Introduction -- Definitions -- Biofilm and Biocides -- Ethanol -- Propan-1-ol -- Propan-2-ol -- Peracetic Acid -- Hydrogen Peroxide -- Glutaraldehyde -- Sodium Hypochlorite -- Triclosan -- Benzalkonium Chloride -- Didecyldimethylammonium Chloride -- Polihexanide -- Chlorhexidine Digluconate -- Octenidine Dihydrochloride -- Silver -- Povidone Iodine -- Antiseptic Stewardship for Alcohol-based Hand Rubs -- Antiseptic Stewardship for Skin Antiseptics -- Antiseptic Stewardship for Surface Disinfectants -- Antiseptic Stewardship for Instrument Disinfectants -- Antiseptic Stewardship for Antimicrobial Soaps -- Antiseptic Stewardship for Wound and Mucosal Antiseptics. |
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Sommario/riassunto |
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This updated and expanded second edition of Antiseptic Stewardship serves as a comprehensive reference guide to common biocidal active substances and antiseptic agents, examining their antimicrobial efficacy and potential to induce cell tolerance, including cross-tolerance to other biocidal agents, as well as cross-resistance to antibiotics. In addition, the book discusses the appropriate and targeted use of biocidal active substances by balancing their expected health benefits against the likelihood of clinically relevant resistance, including misuse and overuse of some products during the COVID-19 pandemic. This guide, which focuses on human, veterinary and household products, helps readers make informed decisions about disinfectants and antiseptic products based on their composition. Various biocidal active substances and antiseptic agents are used for disinfection and antisepsis in healthcare, veterinary medicine, animal production and household products. However, not all of them provide significant health benefits, especially for some products used in human medicine. Antimicrobial soaps, surface disinfectants, instrument disinfectants and wound antiseptics may contain one or more biocidal active ingredients with comparable antimicrobial efficacy, but with large differences in their potential for microbial adaptation and tolerance. Increased bacterial tolerance has been described for several biocidal active substances and antiseptics, sometimes including cross-resistance to antibiotics. The book is therefore intended to help reduce unnecessary selection pressure on emerging pathogens, including by describing non-biocidal alternatives for specific antimicrobial applications, with the aim of retaining the powerful biocidal agents and antiseptics for those applications where there is a clear health benefit (e.g. reduction of healthcare-associated infections). The book addresses healthcare, industrial and veterinary professionals as well as educated laypersons interested in efficient and controlled disinfection strategies. |
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