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Record Nr. |
UNINA9910143740103321 |
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Titolo |
Genetics of autoimmunity [[electronic resource] /] / [editors: Gregory Bock and Jamie Goode] |
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Pubbl/distr/stampa |
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Chichester, UK ; ; Hoboken, NJ, USA, : Wiley, 2005 |
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ISBN |
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1-280-23841-0 |
9786610238415 |
0-470-02139-X |
0-470-02138-1 |
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Descrizione fisica |
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1 online resource (261 p.) |
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Collana |
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Novartis Foundation symposium ; ; 267 |
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Altri autori (Persone) |
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Disciplina |
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Soggetti |
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Autoimmunity |
Autoimmunity - Genetic aspects |
Electronic books. |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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"Symposium on Genomics of Autoimmunity, held at the Novartis Foundation, London, 22-24 June 2004." |
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Nota di bibliografia |
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Includes bibliographical references and index. |
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Nota di contenuto |
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GENETICS OF AUTOIMMUNITY; Contents; Participants; Chair's introduction; Patterns of genetic variation in humans and mice; Discussion; Haplotype tagging in pharmacogenetics; Discussion; Multiple sclerosis: a haplotype association study; Discussion; Mapping genes for asthma and psoriasis; Discussion; Natural genetic variants influencing type 1 diabetes in humans and in the NOD mouse; Discussion; The importance of epistatic interactions in the development of autoimmunity; Discussion; Mapping autoimmune disease genes in humans: lessons from IBD and SLE; Discussion |
A combined genetics and genomics approach to unravelling molecular pathways in coeliac diseaseDiscussion; Progress towards understanding the genetic pathogenesis of systemic lupus erythematosus; Discussion; A molecular dissection of lymphocyte unresponsiveness induced by sustained calcium signalling; Discussion; Genetic lesions in thymic T cell clonal deletion and thresholds for autoimmunity; Discussion; An |
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autoimmune disease-associated CTLA4 splice variant lacking the B7 binding domain signals negatively in T cells; Discussion; Large-scale screens for cDNAs with in vivo activity; Discussion |
Genomic mining of new genes and pathways in innate and adaptive immunityDiscussion; Index of contributors; Subject index |
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Sommario/riassunto |
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This title provides an extremely helpful analysis of genes that may be associated with autoimmunity, and answers questions such as how these genes can be identified, and how the functions of the gene products can be elucidated.Incorporating data on disease-associated chromosomal loci that has been accumulated from inbred mice, the title:* describes how some susceptibility loci may be common to many diseases, whereas others are relatively disease specific* discusses the importance of developing criteria for establishing the significance of these different categories of disease-as |
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2. |
Record Nr. |
UNINA9910141253303321 |
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Autore |
Olofsson Peter <1963-> |
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Titolo |
Probability, statistics, and stochastic processes / / Peter Olofsson, Mikael Andersson |
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Pubbl/distr/stampa |
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Hoboken, N.J., : Wiley, 2012 |
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ISBN |
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9786613622280 |
9781280592454 |
1280592451 |
9781118231296 |
1118231295 |
9781118231302 |
1118231309 |
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Edizione |
[2nd ed.] |
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Descrizione fisica |
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1 online resource (574 p.) |
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Classificazione |
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Altri autori (Persone) |
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Disciplina |
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Soggetti |
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Stochastic processes |
Probabilities |
Mathematical statistics |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Nota di bibliografia |
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Includes bibliographical references and index. |
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Nota di contenuto |
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PROBABILITY, STATISTICS, AND STOCHASTIC PROCESSES; CONTENTS; Preface; Preface to the First Edition; 1 Basic Probability Theory; 1.1 Introduction; 1.2 Sample Spaces and Events; 1.3 The Axioms of Probability; 1.4 Finite Sample Spaces and Combinatorics; 1.4.1 Combinatorics; 1.5 Conditional Probability and Independence; 1.5.1 Independent Events; 1.6 The Law of Total Probability and Bayes' Formula; 1.6.1 Bayes' Formula; 1.6.2 Genetics and Probability; 1.6.3 Recursive Methods; Problems; 2 Random Variables; 2.1 Introduction; 2.2 Discrete Random Variables; 2.3 Continuous Random Variables |
2.3.1 The Uniform Distribution2.3.2 Functions of Random Variables; 2.4 Expected Value and Variance; 2.4.1 The Expected Value of a Function of a Random Variable; 2.4.2 Variance of a Random Variable; 2.5 Special Discrete Distributions; 2.5.1 Indicators; 2.5.2 The Binomial Distribution; 2.5.3 The Geometric Distribution; 2.5.4 The Poisson Distribution; 2.5.5 The Hypergeometric Distribution; 2.5.6 Describing Data Sets; 2.6 The Exponential Distribution; 2.7 The Normal Distribution; 2.8 Other Distributions; 2.8.1 The Lognormal Distribution; 2.8.2 The Gamma Distribution; 2.8.3 The Cauchy Distribution |
2.8.4 Mixed Distributions2.9 Location Parameters; 2.10 The Failure Rate Function; 2.10.1 Uniqueness of the Failure Rate Function; Problems; 3 Joint Distributions; 3.1 Introduction; 3.2 The Joint Distribution Function; 3.3 Discrete Random Vectors; 3.4 Jointly Continuous Random Vectors; 3.5 Conditional Distributions and Independence; 3.5.1 Independent Random Variables; 3.6 Functions of Random Vectors; 3.6.1 Real-Valued Functions of Random Vectors; 3.6.2 The Expected Value and Variance of a Sum; 3.6.3 Vector-Valued Functions of Random Vectors; 3.7 Conditional Expectation |
3.7.1 Conditional Expectation as a Random Variable3.7.2 Conditional Expectation and Prediction; 3.7.3 Conditional Variance; 3.7.4 Recursive Methods; 3.8 Covariance and Correlation; 3.8.1 The Correlation Coefficient; 3.9 The Bivariate Normal Distribution; 3.10 Multidimensional Random Vectors; 3.10.1 Order Statistics; 3.10.2 Reliability Theory; 3.10.3 The Multinomial Distribution; 3.10.4 The Multivariate Normal Distribution; 3.10.5 Convolution; 3.11 Generating Functions; 3.11.1 The Probability Generating Function; 3.11.2 The Moment Generating Function; 3.12 The Poisson Process |
3.12.1 Thinning and SuperpositionProblems; 4 Limit Theorems; 4.1 Introduction; 4.2 The Law of Large Numbers; 4.3 The Central Limit Theorem; 4.3.1 The Delta Method; 4.4 Convergence in Distribution; 4.4.1 Discrete Limits; 4.4.2 Continuous Limits; Problems; 5 Simulation; 5.1 Introduction; 5.2 Random Number Generation; 5.3 Simulation of Discrete Distributions; 5.4 Simulation of Continuous Distributions; 5.5 Miscellaneous; Problems; 6 Statistical Inference; 6.1 Introduction; 6.2 Point Estimators; 6.2.1 Estimating the Variance; 6.3 Confidence Intervals |
6.3.1 Confidence Interval for the Mean in the Normal Distribution with Known Variance |
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Sommario/riassunto |
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Praise for the First Edition "". . . an excellent textbook . . . well organized and neatly written.""-Mathematical Reviews "". . . amazingly interesting . . .""-Technometrics Thoroughly updated to showcase the interrelationships between probability, statistics, and stochastic processes, Probability, Statistics, and Stochastic Processes, Second Edition prepares readers to collect, analyze, and characterize data in their chosen fields. Beginning with three chapters that develop |
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probability theory and introdu |
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3. |
Record Nr. |
UNINA9910894240703321 |
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Titolo |
Postcolonial Europe : journal of literary and cultural studies with a focus on the Eastern and Central Europe |
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Pubbl/distr/stampa |
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Stockholm, : Slaviska Institutionen vid Stockholms Universitet, 2009- |
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Descrizione fisica |
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Classificazione |
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Disciplina |
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Soggetti |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Periodico |
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Note generali |
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