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Record Nr. |
UNINA9910886988303321 |
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Autore |
Baker Jillian G |
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Titolo |
Adrenoceptors / / edited by Jillian G. Baker, Martin C. Michel, Roger J. Summers |
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Pubbl/distr/stampa |
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Cham : , : Springer International Publishing : , : Imprint : Springer, , 2024 |
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ISBN |
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Edizione |
[1st ed. 2024.] |
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Descrizione fisica |
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1 online resource (691 pages) |
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Collana |
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Handbook of Experimental Pharmacology, , 1865-0325 ; ; 285 |
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Altri autori (Persone) |
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MichelMartin C |
SummersRoger J |
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Disciplina |
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Soggetti |
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Pharmacology |
Drugs - Design |
Structure-Based Drug Design |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Nota di contenuto |
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Introduction: a short history of adrenoceptor research -- Structures of Adrenoceptors -- Genetic Variants of Adrenoceptors -- Adrenoceptors: Receptors, Ligands and Their Clinical Uses, Molecular Pharmacology and Assays -- Signalling of adrenoceptors: canonical pathways and new paradigms -- Presynaptic Adrenoceptors -- Roles of b-adrenoceptor subtypes and therapeutics in human cardiovascular disease:- heart failure, tachyarrhythmias and other cardiovascular disorders -- Adrenoceptors and Hypertension -- Adrenoceptors in the Lower Urinary Tract -- Asthma and COPD: A Focus on b-Agonists – Past, Present and Future -- Adrenoceptors in the Eye- Physiological and Pathophysiological Relevance -- Adrenoceptors: A Focus on Psychiatric Disorders and Their Treatments -- Locus Coeruleus and Noradrenergic Pharmacology in Neurodegenerative Disease -- Clinical use of adrenergic receptor ligands in acute care settings -- Adrenoceptor expression and function in the endocrine pancreas -- b-adrenoceptors in cancer: old players and new perspectives. |
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Sommario/riassunto |
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Adrenoceptors have been at the forefront of physiological and pharmacological research for a century. They served as prototypes for rationale drug design as recognized by a Nobel Prize to Sir James Black and for the molecular understanding and structure of G protein- |
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