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Record Nr. |
UNINA9910136797503321 |
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Autore |
Praveen R. Juvvadi |
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Titolo |
Advances in Aspergillus fumigatus pathobiology [[electronic resource] /] / edited by: Frederic Lamoth, Praveen R. Juvvadi and William J. Steinbach |
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Pubbl/distr/stampa |
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Frontiers Media SA, 2016 |
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[Lausanne, Switzerland] : , : Frontiers Media SA, , 2016 |
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©2016 |
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Descrizione fisica |
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1 online resource (109 pages) : illustrations; digital, PDF file(s) |
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Collana |
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Frontiers Research Topics |
Frontiers in Microbiology |
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Soggetti |
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Aspergillus fumigatus |
Pathogenic microorganisms - Research |
Aspergillus fumigatus - pathogenicity |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Nota di bibliografia |
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Includes bibliographical references. |
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Sommario/riassunto |
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Aspergillus fumigatus is a human fungal pathogen that causes invasive aspergillosis (IA), a major infectious cause of death in the expanding population of immunocompromised individuals such as cancer patients and transplant recipients. The mortality of IA remains high (30-70%) and emerging resistance to triazoles, the first-line antifungal drug class, is of particular concern. Second-line therapies for IA are limited by their toxicity (polyenes) or their lack of fungicidal activity (echinocandins). Identification of novel antifungal targets is an urgent need for improving the outcome of IA. A. fumigatus is a filamentous fungus exhibiting a complex developmental cycle and elaborated mechanisms of adaptation to allow the initiation and progression of infection in the human host. The fungal cell wall, with its unique and dynamic structure, is crucial for protecting cell integrity and evading the host immune system, also contributing to biofilm formation and virulence, and thus representing an ideal antifungal target. However, compensatory mechanisms of cell wall remodeling are present and still |
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poorly understood. Recent work has highlighted the key roles of intracellular signaling proteins or molecular chaperones, such as calcineurin or the heat shock protein 90 (Hsp90), in morphogenesis, stress responses, virulence and antifungal resistance. The emergence of azole resistance implies various and complex mechanisms that need to be further elucidated. Other important processes, such as biosynthetic pathways and toxin/metabolite production are important for fungal survival and propagation in the host environment, ultimately leading to disease. Moreover, the host immune response is a determinant factor in influencing the course of infection. The objective of this topic issue is to provide an overview of the recent advances in our understanding of A. fumigatus pathobiology and of IA pathogenesis to outline future research. The topic will focus on mechanisms of antifungal resistance, stress adaptation and virulence and the discovery of potential novel antifungal targets via a genetic and molecular approach. Articles related to the interactions of A. fumigatus with the host immune system in the development of IA are also welcomed. We intend to collect a large variety of article types, including complete and comprehensive reviews, expert opinions, hypotheses, and also original research articles illustrating new aspects and approaches on this topic. Through this project, we expect to open an opportunity for all scientists in the world dedicated to the pathobiology of this major human fungal pathogen to share their knowledge, experience and opinions and assemble their efforts in defining main research axes to progress in our quest of improved antifungal strategies against IA. |
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2. |
Record Nr. |
UNINA9910886095803321 |
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Autore |
Kumar Sachin |
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Titolo |
Clean Energy Transition-via-Biomass Resource Utilization : A Way to Mitigate Climate Change / / edited by Sachin Kumar, Suresh Sundaramurthy, Deepak Kumar, Anuj K. Chandel |
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Pubbl/distr/stampa |
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Singapore : , : Springer Nature Singapore : , : Imprint : Springer, , 2024 |
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ISBN |
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Edizione |
[1st ed. 2024.] |
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Descrizione fisica |
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1 online resource (327 pages) |
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Collana |
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Green Energy and Technology, , 1865-3537 |
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Altri autori (Persone) |
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SundaramurthySuresh |
KumarDeepak |
ChandelAnuj K |
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Disciplina |
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Soggetti |
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Energy policy |
Bioclimatology |
Bioremediation |
Renewable energy sources |
Energy Policy, Economics and Management |
Climate Change Ecology |
Environmental Biotechnology |
Renewable Energy |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Nota di contenuto |
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1. Sustainable utilization of biomass resources -- 2. Biomass resources and potential for its applications in energy and platform chemicals with 3G biorefinery approaches -- 3. Agro-forestry biomass as a potential bioresource for climate change mitigation -- 4. Vegetable oil seeds as biomass resource for potential applications in biofuel and biomaterials -- 5. Optimization of Co-digestion of fish waste for methane generation and utilization of slurry for organic farming. |
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Sommario/riassunto |
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This book highlights clean energy transition via sustainable utilization of biomass resources, viz. forestry, agriculture, agroforestry, grassland, and seaweeds to climate change mitigation. Bioresources have tremendous potential to mitigate global warming. Also, biomass is |
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expected to play a multifunctional role including food production, source of energy and fodder, biodiversity conservation, and yield of goods and services to the society. It brings together perspectives of various communities involved in the research and regulation of bioenergy deployment in the context of climate change mitigation. The book presents the way forward to policy makers and stakeholders involved with bioenergy development. This development may be directive challenges in the transport sector where options such as hydrogen and electric vehicles relying on hydro, wind, and solar PV will require decades to become established on a substantial scale. Furthermore, meeting ambitious climate change targets will also require environment-friendly fuels in air and marine transport where no alternative to biofuels is currently available. The process design-via-onion model for sustainable utilization of biomass resources is also one of the most important subjects of the book. This book includes state-of-the-art approaches on bottlenecks and circular economy analysis for biomass energy use to reduce climate change and sustainability frameworks to guide bioenergy development. |
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