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1. |
Record Nr. |
UNINA9910645944803321 |
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Autore |
Schepers Anna Veronika |
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Titolo |
Intermediate Filament Mechanics Across Scales : From Single Filaments to Single Interactions and Networks in Cells / / Anna Veronika Schepers |
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[Place of publication not identified] : , : Universitätsverlag Göttingen, , 2022 |
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Descrizione fisica |
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1 online resource (iv, 234 pages) : illustrations |
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Collana |
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Göttingen Series in Biophysics |
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Disciplina |
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Soggetti |
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Cytoplasmic filaments |
Optical tweezers |
Cells - Mechanical properties |
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Materiale a stampa |
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Livello bibliografico |
Monografia |
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Sommario/riassunto |
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The mechanical properties of cells are largely determined by the cytoskeleton. The cytoskeleton is an intricate and complex structure formed by protein filaments, motor proteins, and crosslinkers. The three main types of protein filaments are microtubules, actin filaments, and intermediate filaments ( IFs ). Whereas the proteins that form microtubules and actin filaments are exceptionally conserved throughout cell types and organisms, the family of IFs is diverse. For example, the IF protein vimentin is expressed in relatively motile fibroblasts, and keratin IFs are found in epithelial cells. This variety of IF proteins might therefore be linked to the various mechanical properties of different cell types. In the scope of this thesis, I combine studies of IF mechanics on different time scales and in systems of increasing complexity, from single filaments to networks in cells. This multiscale approach allows for the simplification necessary to interpret observations while adding increasing physiological context in subsequent experiments. We especially focus on the tunability of the IF mechanics by environmental cues in these increasingly complex systems. In a series of experiments, including single filament elongation studies, single filament stretching measurements with optical tweezers, filament-filament interaction measurements with four |
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optical tweezers, microrheology, and isotropic cell stretching, we characterize how electrostatic (pH and ion concentration) and hydrophobic interactions (detergent) provide various mechanisms by which the mechanics of the IF cytoskeleton can be tuned. These studies reveal how small changes, such as charge shifts, influence IF mechanics on multiple scales. In combination with simulations, we determine the mechanisms by which charge shifts alter single vimentin filament mechanics and we extract energy landscapes for interactions between single filaments. Such insights will provide a deeper understanding of the mechanisms by which cells can maintain their integrity and adapt to the mechanical requirements set by their environment. |
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2. |
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UNISALENTO991001042309707536 |
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Autore |
Berkeley Physics Laboratory |
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Titolo |
Laboratory physics : Parts C and D / Berkeley Physics Laboratory |
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New York : McGraw-Hill Book Co., c1966 |
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Descrizione fisica |
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Physics-Laboratory manuals |
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Monografia |
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3. |
Record Nr. |
UNINA9910886072203321 |
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Autore |
Oetzel Sebastian |
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Titolo |
33 Phenomena of Purchasing Decisions : Understanding Customer Behavior - Knowledge and Inspiration / / by Sebastian Oetzel, Andreas Luppold |
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Pubbl/distr/stampa |
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Wiesbaden : , : Springer Fachmedien Wiesbaden : , : Imprint : Springer Gabler, , 2024 |
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ISBN |
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Edizione |
[1st ed. 2024.] |
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Descrizione fisica |
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1 online resource (180 pages) |
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Disciplina |
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Materiale a stampa |
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Livello bibliografico |
Monografia |
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Nota di bibliografia |
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Includes bibliographical references. |
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Nota di contenuto |
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Understanding the customer's purchasing decisions per purchasing phase -- Advertising - How do I become aware of the product? -- How do I plan the purchase? -- What role does the price play in the purchasing decision? -- What influence do promotions have on the purchasing decision? -- What factors increase the likelihood of an unplanned purchase? -- What factors influence the purchasing decision in the shop? -- How do I behave at the shelf? After the purchase. |
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Sommario/riassunto |
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This book delves into understanding customer purchase decisions: How do customers decide? Are they overwhelmed by choice? Can a decoy on the shelf influence them? How do factors like hunger and caffeine affect their behavior? Marketing and sales professionals often grapple with uncertain decisions, relying more on intuition than concrete knowledge. In 33 concise chapters, Sebastian Oetzel and Andreas Luppold, experts in shopper marketing and research, explore factors shaping purchasing decisions. They examine various angles, challenging common assumptions through economic, behavioral, and psychological lenses. Ideal for professionals and academics involved in purchase decisions, as well as those curious about their own decision-making processes. Includes insights on: The impact of positive framing and numerical presentation. Why "€ 0.-" surpasses "for free" and the allure of complimentary offerings over discounts. How individuality can breed dissatisfaction and the dynamics of shopping alone vs. with others. The |
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paradox of price guarantees raising prices yet enhancing retailer image. Unconscious stimuli influencing decisions and their counterintuitive effects. Plus, 28 more intriguing phenomena. The Authors Dr. Sebastian Oetzel is a Professor of General Business Administration, particularly Marketing, at the Department of Business at Fulda University of Applied Sciences. His research focuses on the application of quantitative methods to optimize marketing decisions. Andreas Luppold, Dipl. Kaufmann, is the Managing Partner of the consulting firm Innobrands GmbH and also serves as a Leading Consultant & Company Advisor at Yagora GmbH, a market research and consulting firm specializing in purchase decision behavior. The translation was done with the help of artificial intelligence. A subsequent human revision was done primarily in terms of content. This book is a translation of an original German edition. The translation was done with the help of artificial intelligence (machine translation by the service DeepL.com). A subsequent human revision was done primarily in terms of content, so that the book will read stylistically differently from a conventional translation. |
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4. |
Record Nr. |
UNIORUON00526477 |
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Autore |
Gombrich, Richard F. |
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Titolo |
Il ritmo irregolare del cambiamento : Il buddhismo Theravāda dalle origini a oggi / Richard F. Gombrich ; Nella traduzione di Luca Piscopo |
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Titolo uniforme |
Theravada Buddhism : A social history from ancient Benares to modern Colombo |
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Buddhismo theravāda - Sri Lanka |
Buddhismo theravāda - Storia |
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Materiale a stampa |
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Livello bibliografico |
Monografia |
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