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Record Nr. |
UNINA9910878078503321 |
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Titolo |
Mass spectrometry in drug metabolism and pharmacokinetics / / edited by Ragu Ramanathan |
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Pubbl/distr/stampa |
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Hoboken, N.J., : Wiley, c2009 |
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ISBN |
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1-118-21157-X |
1-282-68754-9 |
9786612687549 |
0-470-40981-9 |
0-470-40980-0 |
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Descrizione fisica |
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1 online resource (403 p.) |
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Classificazione |
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Altri autori (Persone) |
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Disciplina |
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Soggetti |
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Drugs - Design |
Drugs - Metabolism - Research - Methodology |
Mass spectrometry |
Pharmacokinetics - Research - Methodology |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references and index. |
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Nota di contenuto |
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Mass Spectrometry in Drug Metabolism and Pharmacokinetics; Contents; Preface; About the Editor; Contributors; 1. Evolving Role of Mass Spectrometry in Drug Discovery and Development; 2. Quantitative Bioanalysis in Drug Discovery and Development: Principles and Applications; 3. Quadrupole, Triple-Quadrupole, and Hybrid Linear Ion Trap Mass Spectrometers for Metabolite Analysis; 4. Applications of Quadrupole Time-of-Flight Mass Spectrometry in Reactive Metabolite Screening; 5. Changing Role of FTMS in Drug Metabolism |
6. High-Resolution LC-MS-Based Mass Defect Filter Approach: Basic Concept and Application in Metabolite Detection7. Applications of High-Sensitivity Mass Spectrometry and Radioactivity Detection Techniques in Drug Metabolism Studies; 8. Online Electrochemical-LC-MS Techniques for Profiling and Characterizing Metabolites and Degradants; 9. LC-MS Methods with Hydrogen/Deuterium Exchange for Identification of Hydroxylamine, N-Oxide, and Hydroxylated Analogs of Desloratadine; 10. Turbulent-Flow LC-MS: Applications for Accelerating |
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Pharmacokinetic Profiling and Metabolite Identification |
11. Desorption Ionization Techniques for Quantitative Analysis of Drug Molecules12. MALDI Imaging Mass Spectrometry for Direct Tissue Analysis of Pharmaceuticals; Index |
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Sommario/riassunto |
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This timely reference discusses mass spectrometry in drug metabolism and pharmacokinetic studies. With contributions by professionals from the pharmaceutical industry, this book begins with a review of current mass spectrometry techniques and applications, followed by discussions of various methods for using MS in drug metabolism studies and pharmacokinetics. Highlighting the critical importance of ADME studies for understanding how a drug is absorbed, distributed, metabolized, and excreted by the body, the book s focuses on the use of LC/MS and MALDI-MS. This is a valuable reference for scien |
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