Functions of the proteoglycans

• Record Nr.: UNINA9910877853103321
• Pubbl/distr/stampa: Chichester ; ; New York, : Wiley, 1986
• ISBN: 1-282-34585-0; 9786612345852; 0-470-51338-1; 0-470-51339-X
• Descrizione fisica: 1 online resource (311 p.)
• Collana: Ciba Foundation symposium ; ; 124
• Altri autori (Persone): EveredDavid; WhelanJulie
• Disciplina: 574.19245; 612; 612.015754
• Soggetti: Proteoglycans - Physiological effect; Physiology
• Lingua di pubblicazione: Inglese
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Note generali: Editors: David Evered (organizer) and Julie Whelan.; "Symposium on Functions of the Proteoglycans, held at the Ciba Foundation, London, 14-16 January 1986"--Contents p. [v].; "A Wiley-Interscience publication."
• Nota di bibliografia: Includes bibliographies and indexes.
• Nota di contenuto: FUNCTIONS OF THE PROTEOGLYCANS; Contents; Participants; Introduction; The properties and turnover of hyalu ronan; Cartilage proteog lycans; Biological roles of dermatan sulphate proteog lycans; Common structures of the core proteins of interstitial p rot eog lycans; Biosynthesis and processing of proteodermatan sulphate; ProteogIycan-collagen interactions; The functions of the heparan sulphate proteoglycans; Functions of proteoglycans at the cel surface; Heparan sulphate proteoglycan as mediator of some adhesive responses and cytoskeletal reorganization of cells on fibronectin matrices: independent versus cooperative functionsGeneral discussion I; Structure and function of basement membrane proteoglycans; Biosynthesis and structure of the basement rnern brane proteoglycan containing he paran sul p hate side-chains; General discussion II; Vascular cel I p roteog lycans: evidence for metabolic modulation; ; Molecular cloning of proteoglycan core proteins; Secretory granule proteoglycans of mast cells and natural killer cells; Chairman's summing-upIndex of contributors; Subject index
• Sommario/riassunto: Presents a comprehensive review of current proteoglycan research, which is providing fresh insights into many major chronic diseases. The proteoglycans are a family of macromolecules which contain one or more glycosaminoglycan chains covalently bound to a core protein. Proteoglycans are a major component of the extracellular matrix of connective tissues and help to determine its volume, resiliency, and organization. They are an important medium through which nutrients, hormones, and other solutes are transported to cells, and they play a significant role in cell-cell interactions. Disturbances