The molecular biology and pathology of elastic tissues / / [editors Derek J. Chadwick and Jamie A. Goode]

• Record Nr.: UNINA9910877644703321
• Pubbl/distr/stampa: Chichester ; ; New York, : J. Wiley, 1995
• ISBN: 1-282-45539-7; 9786612455391; 0-470-51477-9; 0-470-51478-7
• Descrizione fisica: 1 online resource (373 p.)
• Collana: Ciba Foundation symposium ; ; 192
• Altri autori (Persone): ChadwickDerek; GoodeJamie
• Disciplina: 611/.0182
• Soggetti: Elastin; Elastic tissue - Diseases - Molecular aspects
• Lingua di pubblicazione: Inglese
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Note generali: "Symposium on the Molecular Biology and Pathology of Elastic Tissues, held at the Windsor Golf and Country Club, Nairobi, Kenya, 1-3 November 1994"--P. v.; Editors: Derek J. Chadwick and Jamie A. Goode.
• Nota di contenuto: THE MOLECULAR BIOLOGY AND PATHOLOGY OF ELASTIC TISSUES; Contents; Participants; Preface; Chairman's in trod uction; Molecular biophysics of elastin structure, function and pathology; UItrastructure of elastin; General discussion I; Structure of the elastin gene; Regulation of elastin synthesis in pathological states; Catalytic properties and structural components of lysyl oxidase; General discussion II; The structure and function of fibrillin; Elastin gene mutations in transgenic mice; Elastic fibre assembly: macromolecular interactions; The 67 kDa spliced variant of b-galactosidase serves as a reusable protective chaperone for tropoelastinGeneral discussion Ill; Elastin in lung development and disease; Elastin and mechanoreceptor mechanisms with special reference to the mammalian carotid sinus; Skin elastic fibres: regulation of human elastin promoter activity in transgenic mice; Elastin in systemic and pulmonary hypertension; ; General discussion IV; Elastin in blood vessels; General discussion V; Elastase in the prevention of arterial ageing and the treatment of the rosclerosis; Interaction of tumour cells with elastin and the metastatic phenotypeA role for neutrophil elastase in solar elastosis; Closing reflections; Index of contributors; Subject Index
• Sommario/riassunto: Drawing together contributions from a diverse group of international experts in the field, this collection of papers examines the biology and pathology of elastin at the molecular level. Topics include the structure, ultrastructure and function of elastin; elastin regulation; elastin's role in aging, lung development and disease and atherosclerosis; as well as related aspects of pharmacology and nutrition.