Nanocarrier Vaccines : Biopharmaceutics-Based Fast Track Development

• Record Nr.: UNINA9910877230703321
• Autore: Chavda Vivek P
• Pubbl/distr/stampa: Newark : , : John Wiley & Sons, Incorporated, , 2024; ©2024
• ISBN: 9781394175468
• Edizione: [1st ed.]
• Descrizione fisica: 1 online resource (519 pages)
• Altri autori (Persone): ApostolopoulosVasso
• Soggetti: Nanoparticles; Vaccines
• Lingua di pubblicazione: Inglese
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Nota di contenuto: Cover -- Title Page -- Copyright Page -- Dedication Page -- Contents -- Preface -- Part 1 General -- Chapter 1 History of Nanoparticles -- 1.1 Introduction -- 1.2 History of Nanoparticles -- 1.3 Modern Development of Nanoparticles -- 1.4 Type of Nanoparticles -- 1.5 Properties of Nanoparticles -- 1.5.1 Size -- 1.5.2 Shape -- 1.5.3 Surface Area -- 1.6 Importance of Nanoparticles -- 1.7 Conclusion and Future Prospect -- References -- Chapter 2 Composition of Nanoparticles -- 2.1 Introduction -- 2.2 Types of Nanoparticles -- 2.2.1 Polymeric Nanoparticles -- 2.2.1.1 Polymeric Micelles -- 2.2.1.2 Dendrimer -- 2.2.1.3 Nanosphere -- 2.2.1.4 Nanocapsule -- 2.2.1.5 Polymersome -- 2.2.1.6 Nanocomplex -- 2.2.1.7 Nanogel -- 2.2.2 Inorganic Nanoparticle -- 2.2.2.1 Gold Nanoparticle -- 2.2.2.2 Silica Nanoparticle -- 2.2.2.3 Magnetic Nanoparticle -- 2.2.2.4 Quantum Dots -- 2.2.2.5 Nanocarbon -- 2.2.3 Hybrid Nanoparticle -- 2.2.3.1 Cell Membrane Coated Nanoparticle -- 2.2.3.2 Lipid Polymer Nanoparticle -- 2.2.3.3 Organic-Inorganic Nanocomposite -- 2.2.4 Bioinspired Nanoparticle -- 2.2.4.1 Exosomes -- 2.2.4.2 Protein Nanoparticle -- 2.2.4.3 DNA Nanostructure -- 2.2.5 Lipid-Based Nanoparticle -- 2.2.5.1 Liposome -- 2.2.5.2 Lipoplex -- 2.2.5.3 Solid Lipid Nanoparticle -- 2.3 Composition of Nanoparticles -- 2.3.1 Chitosan -- 2.3.2 Albumin -- 2.3.3 Polylactic Acid -- 2.3.4 Polylactide-co-glycolide (PLGA) -- 2.3.5 Polyacrylate -- 2.4 Synthesis of ; Nanoparticles -- 2.4.1 Top-Down Approach -- 2.4.1.1 Ball Milling -- 2.4.1.2 Physical Vapor Deposition (PVD) -- 2.4.1.3 Melt Mixing -- 2.4.1.4 Pulse Laser Ablation -- 2.4.2 Bottom-Up Approach -- 2.4.2.1 Chemical Vapor Deposition (CVD) -- 2.4.2.2 Thermal Decomposition Method -- 2.4.2.3 Chemical Methods -- 2.4.2.4 Biological Methods -- 2.5 Nanoparticle Characterization by Various Instrumental Techniques.; 2.5.1 Dynamic Light Scattering (DLS) -- 2.5.2 Zeta Potential -- 2.5.3 Microscopic Techniques to Characterize Nanoparticles -- 2.5.3.1 Scanning Electron Microscopy (SEM) -- 2.5.3.2 Transmission Electron Microscopy (TEM) -- 2.5.4 Spectroscopic Techniques to Characterize Nanoparticles -- 2.5.4.1 Ultraviolet-Visible Spectroscopy (UV-Vis) -- 2.5.4.2 Raman Spectroscopy -- 2.5.4.3 Fourier Transform Infrared Spectroscopy (FTIR) -- 2.5.5 X-Ray Diffraction Method (XRD) -- 2.6 Understanding Nanotoxicity: Potential Risks and Implications -- 2.7 Conclusion -- References -- Chapter 3 Nanotechnology and Vaccine Development -- 3.1 Introduction -- 3.2 Overview of Vaccine Development -- 3.3 Advantages of Nanoparticles in Vaccine Delivery -- 3.4 Types of Nanoparticles as Vaccine Carriers -- 3.4.1 Liposomes -- 3.4.2 Polymer-Based Nanoparticles -- 3.4.3 Virus-Like Particles (VLPs) -- 3.4.4 Nanogels -- 3.4.5 Inorganic Nanoparticles -- 3.5 Development of Nanoparticle-Based Vaccine -- 3.5.1 Viral Vector-Based Nanoparticle -- 3.5.2 Lipid-Based Nanoparticles -- 3.5.3 DNA-Based Nanoparticles -- 3.5.4 mRNA-Based Nanoparticles -- 3.5.5 Protein-Based Nanoparticles -- 3.6 Adjuvants and their Role in Vaccine Development -- 3.7 Nanoscale Adjuvants -- 3.8 Advantages -- 3.9 Techniques for Nanoscale Adjuvants -- 3.10 Route of Administration for Vaccines -- 3.11 Recent Advances in Nanotechnology-Based Vaccines -- 3.12 The Regulatory Perspective of Nanoparticle-Based Vaccine Development -- 3.13 Future Prospects -- 3.14 Conclusion -- References -- Chapter 4 Nanoparticle Formulations: A Sustainable Approach to Biodegradable and Non-Biodegradable Products -- 4.1 Introduction -- 4.2 Types of Nanoparticles -- 4.3 Preparation of Nanoparticles -- 4.4 Factors Affecting Selection of Method -- 4.4.1 Pressure -- 4.4.2 Particle Shape and Size -- 4.4.3 Environment -- 4.4.4 Pore Size.; 4.4.5 Particular Method or Technique -- 4.4.6 Cost of Preparation -- 4.4.7 Proximity -- 4.4.8 Time -- 4.4.9 Other Variables -- 4.5 Polymers Used in NP Formulation -- 4.6 Nanoparticle Formulations Based on Biodegradable Polymers -- 4.7 Nanoparticle Formulations Based on Non-Biodegradable Polymers -- 4.8 Nanoparticle Formulations Based on Natural Polymers -- 4.9 Challenges in NPs from Laboratory to Industrial Scale-Up -- 4.10 Nanoparticle-Based Approved &amp -- Marketed Formulations -- 4.11 Future Aspects &amp -- Conclusion -- References -- Chapter 5 Nanoparticle Properties: Size, Shape, Charge, Inertness, Efficacy, Morphology -- 5.1 Introduction -- 5.2 Applications of Nanoparticle Formulations -- 5.3 Interaction with Cells -- 5.4 Properties of Nanoparticles -- 5.4.1 Classification of Nanoparticle Properties -- 5.4.1.1 Physicochemical Properties -- 5.4.1.2 Optical Properties -- 5.4.1.3 Magnetic Properties -- 5.4.1.4 Catalytic Properties -- 5.4.1.5 Mechanical Properties -- 5.4.2 Different Properties -- 5.4.2.1 Size -- 5.4.2.2 Shape -- 5.4.2.3 Charge -- 5.4.2.4 Inertness -- 5.4.2.5 Efficacy -- 5.4.2.6 Morphology -- 5.5 Role of Physicochemical Properties in Nanoparticle Toxicity -- 5.6 Conclusion -- References -- Part 2 Nanoparticles to Deliver Antigen -- Chapter 6 Viral Vector-Based Nanoparticles -- 6.1 Introduction -- 6.2 Characteristics of Viral Vector-Based Nanoparticles -- 6.3 Applications -- 6.3.1 Viral Nanoparticles for Drug Delivery -- 6.3.1.1 Antimicrobial Therapies -- 6.3.1.2 Cardiovascular Therapies -- 6.3.2 Viral ; Nanoparticles for Imaging -- 6.3.2.1 Nanoparticles are Used in PET/SPECT Scans -- 6.3.2.2 Nanoparticles Used in Ultrasonic Tests -- 6.3.2.3 Nanoparticles Utilized in CT Scans -- 6.3.2.4 Nanoparticles Employed in MRI Biomedical Applications -- 6.3.2.5 Illustrations of Nanoparticles Utilized in Fluorescence-Based Biological Applications.; 6.3.3 Viral Nanoparticles for Immunotherapy -- 6.3.4 Viral Nanoparticles for Theranostic Applications -- 6.4 Novel Advancements in Applications of Viral Nanoparticles -- 6.5 Limitations and Prospects of Viral Vector-Based Nanoparticle Approach -- 6.6 Conclusion -- Acknowledgment -- References -- Chapter 7 Lipid-Based Nanoparticles -- 7.1 Introduction -- 7.2 Types of Lipid-Based Nanoparticles -- 7.2.1 Solid Lipid Nanoparticles (SLNs) -- 7.2.2 Nanostructured Lipid Carriers (NLCs) -- 7.3 Synthesis of Lipid-Based Nanoparticles -- 7.3.1 Introduction to Lipids -- 7.3.2 Methods for Formulating Lipid Nanoparticles -- 7.3.2.1 High-Pressure Homogenization -- 7.3.2.2 Solvent Emulsification-Evaporation -- 7.3.2.3 Microemulsion-Based Method -- 7.3.2.4 Hot-Melt Homogenization -- 7.3.2.5 Spray Drying -- 7.3.2.6 Solvent Injection Method -- 7.3.2.7 Microfludics -- 7.4 Characterization of Lipid Nanoparticles -- 7.4.1 Size and Shape -- 7.4.2 Surface Charge -- 7.4.2.1 Analytical Techniques for Surface Charge Characterization -- 7.4.2.2 Zeta Potential Measurement -- 7.4.2.3 Electrophoresis -- 7.4.2.4 Isoelectric Focusing -- 7.4.3 Encapsulation Efficiency -- 7.4.3.1 Factors Affecting Encapsulation Efficiency -- 7.4.3.2 Analytical Techniques for Encapsulation Efficiency Characterization -- 7.4.4 Stability -- 7.4.4.1 Factors Affecting Stability -- 7.4.4.2 Analytical Techniques for Stability Characterization -- 7.5 Applications of Lipid-Based Nanoparticles in Vaccines -- 7.5.1 Enhancement of Immune Response -- 7.5.2 Targeted Delivery -- 7.5.2.1 Cancer Immunotherapy -- 7.5.2.2 mRNA-Based Vaccines -- 7.5.2.3 Gene Therapy -- 7.5.3 Adjuvant Effects -- 7.5.3.1 mRNA COVID-19 Vaccines -- 7.5.3.2 Human Papillomavirus (HPV) Vaccine -- 7.5.3.3 Influenza Vaccine -- 7.6 Challenges and Future Directions -- 7.6.1 Safety and Toxicity Concerns -- 7.6.1.1 Preclinical Safety Evaluation.; 7.6.1.2 Human Pharmacology Studies -- 7.6.1.3 Postmarketing Surveillance -- 7.6.1.4 Adverse Event Reporting -- 7.6.2 Stability Issues -- 7.6.2.1 Formulation Optimization -- 7.6.2.2 Analytical Method Development -- 7.6.2.3 Accelerated Stability Studies -- 7.6.2.4 Quality by Design (QbD) -- 7.6.3 Scale-Up Production Challenges -- 7.6.3.1 Equipment Design -- 7.6.3.2 Process Optimization -- 7.6.3.3 Regulatory Compliance -- 7.6.4 Opportunities for Future Research -- 7.6.4.1 Novel Antigen and Adjuvant Formulations -- 7.6.4.2 Targeted Delivery -- 7.6.4.3 Manufacturing Process Optimization -- 7.6.4.4 Immunological Mechanisms -- 7.6.4.5 Opportunities for Future Research -- 7.7 Conclusion -- References -- Chapter 8 Nanoparticle-Based mRNA Vaccines: Are We One Step Closer to Targeted Cancer Therapy? -- 8.1 Introduction -- 8.2 Use of mRNA in Vaccines: Advantages and Challenges -- 8.3 How Do mRNA Vaccines Work? -- 8.4 Nanocarriers for mRNA Delivery -- 8.4.1 Liposomes and RNA Lipoplexes -- 8.4.2 Lipid Nanoparticles -- 8.4.3 Polymer-Based Nanoparticles -- 8.4.4 Hybrid Nanoparticles -- 8.5 Nanoparticle-Based mRNA Vaccines in Cancer Therapy -- 8.5.1 Breast Cancer -- 8.5.2 Colorectal Cancer -- 8.5.3 Lung Cancer -- 8.5.4 Glioma Tumor -- 8.5.5 Other Tumors -- 8.6 Clinical Trials -- 8.6.1 Considerations for Clinical Translation -- 8.7 Conclusion -- References -- Chapter 9 Protein Delivery by Nanoparticles -- 9.1 Introduction -- 9.2 Major Challenges in Protein Delivery -- 9.3 Nanotechnology -- 9.4 Nanoparticles -- 9.4.1 Nanocarriers -- 9.4.2 Protein Nanocarrier -- ; 9.4.3 Protein and Its Type Used to Produce Protein Nanoparticles -- 9.4.3.1 Silk Protein Fibroin -- 9.4.3.2 Human Serum Albumin -- 9.4.3.3 Gliadin -- 9.4.3.4 Gelatin -- 9.4.3.5 Legumin -- 9.4.3.6 30Kc19 Protein Obtained from Silkworm Hemolymph -- 9.4.3.7 Ferritin -- 9.5 Methods of Preparation.; 9.5.1 Chemical Methods.
• Sommario/riassunto: This book, edited by Vivek P. Chavda, provides a comprehensive overview of nanocarrier vaccines, focusing on the fast-track development of these innovative solutions in immunology. It covers the history, types, and properties of nanoparticles, as well as their applications in vaccine delivery. The book delves into the advantages of using nanoparticles as vaccine carriers, exploring various types such as liposomes, polymer-based nanoparticles, and virus-like particles. Additionally, it addresses the synthesis, formulation, and characterization of nanoparticles, along with the potential risks associated with nanotoxicity. The text is targeted at researchers, professionals, and students in the fields of pharmacy, biotechnology, and nanotechnology, aiming to equip them with the knowledge to advance in vaccine development and nanoparticle technology.