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Record Nr. |
UNINA9910877133703321 |
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Titolo |
Charge transfer in DNA : from mechanism to application / / edited by Hans-Achim Wagenknecht |
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Pubbl/distr/stampa |
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Weinheim, Germany, : Wiley-VCH, c2005 |
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ISBN |
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1-280-52120-1 |
9786610521203 |
3-527-60662-9 |
3-527-60690-4 |
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Descrizione fisica |
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1 online resource (247 p.) |
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Altri autori (Persone) |
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Disciplina |
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Soggetti |
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Charge transfer in biology |
DNA |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references and index. |
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Nota di contenuto |
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Charge Transfer in DNA; Foreword; Preface; Contents; List of Contributors; 1 Principles and Mechanisms of Photoinduced Charge Injection, Transport, and Trapping in DNA; 1.1 Introduction; 1.2 Synthetic DNA-Donor-Acceptor Systems; 1.3 Photoinduced Oxidative Hole Transfer vs. Reductive Electron Transfer in DNA; 1.4 Hole Transfer and Hole Hopping in DNA; 1.4.1 Spectroscopic Studies and Mechanisms of Hole Transfer in DNA; 1.4.2 Biochemical and Chemical Hole Trapping in DNA; 1.4.3 Modulation of DNA-mediated Hole Transfer; 1.5 Reductive Electron Transfer in DNA |
1.5.1 Mechanisms of Electron Transfer in DNA1.5.2 Outlook: Electron Transfer in DNA Chip Technology; 1.6 Conclusions; References; 2 Sequence-dependent DNA Dynamics: The Regulator of DNA-mediated Charge Transport; 2.1 Introduction; 2.2 Experimental Approaches to Studies of DNA-mediated Charge Transport Over Varied Energetic and Time Regimes; 2.2.1 Metallointercalators, Organic Intercalators, and Modified Bases as Probes; 2.2.1.1 Metallointercalators; 2.2.1.2 Organic Intercalators; 2.2.1.3 Modified Bases; 2.2.2 Spectroscopic, Biochemical, and Electrochemical Approaches |
2.3 Understanding the Fundamental Parameters Governing DNA- |
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mediated Charge Transport2.3.1 The Base Pair π-Stack of Double-helical DNA Regulates Charge Transport; 2.3.1.1 Spectroscopic Investigations of Charge Transport through DNA; 2.3.1.2 Biochemical Investigations of Long-range Oxidative Damage; 2.3.2 The Role of the Oxidant in DNA-mediated Charge Transport: Energetics, Coupling, Lifetimes, and Back Electron Transfer; 2.3.2.1 Rate Constants and Net Yields of Charge Injection; 2.3.2.2 Long-range Oxidative Damage; 2.3.3 Conformational Dynamics of the DNA Bases |
2.3.4 Charge Delocalization and Participation of All DNA Bases2.3.5 Transport of Holes Versus "Excess Electrons"; 2.4 A Mechanistic Model for DNA-mediated Charge Transport: Beyond Superexchange and Incoherent Hopping; 2.5 DNA-mediated Charge Transport in Biology; 2.6 Conclusions and Outlook; References; 3 Excess Electron Transfer in DNA Probed with Flavin- and Thymine Dimer-modified Oligonucleotides; 3.1 Introduction; 3.2 Excess Electron Transfer-driven DNA Repair by DNA Photolyases; 3.3 Excess Electron Transfer in DNA; 3.3.1 Distance Dependence; 3.3.2 Directional Dependence |
3.3.3 Sequence Dependence3.4 The Catalytic Electron? Or, Can One Electron Repair More Than One Dimer Lesion?; 3.5 Future Directions; References; 4 Dynamics of Photoinitiated Hole and Electron Injection in Duplex DNA; 4.1 Introduction; 4.2 DNA Hairpin Synthesis, Structure, and Energetics; 4.2.1 Hairpin Synthesis and Structure; 4.2.2 Electron Transfer Energetics; 4.2.3 Electron Transfer Dynamics; 4.3 Hole Injection; 4.3.1 Distance Dependence; 4.3.2 Electron Donor-Acceptor End-capped Hairpins; 4.3.3 Variation of the Tunneling Energy Gap; 4.3.4 Driving Force Dependence |
4.3.5 GG and GGG as Hole Acceptors |
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Sommario/riassunto |
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The past few years have witnessed intense research in this fascinating field as well as many controversial discussions. Now the time is ripe for a comprehensive book covering not only theoretical aspects, but also such mechanistic topics as principles and mechanisms of photoinduced charge injection, transport and trapping in DNA, sequence-dependent DNA dynamics, spectroscopic investigations of hole transport and much more. From the contents:* Principles and Mechanisms of Photoinduced Charge Injection, Transport and Trapping in DNA* Sequence-Dependent DNA Dynamics: The Regulator |
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