Tissue engineering of cartilage and bone / / [editors, Gregory Bock, Jamie Goode]

• Record Nr.: UNINA9910876958403321
• Pubbl/distr/stampa: Chichester, West Sussex ; ; Hoboken, NJ, : J. Wiley, 2003
• ISBN: 1-280-27178-7; 9786610271788; 0-470-66888-1; 0-470-86423-0; 0-470-86797-3
• Descrizione fisica: 1 online resource (263 p.)
• Collana: Novartis Foundation symposium ; ; 249
• Altri autori (Persone): BockGregory; GoodeJamie
• Disciplina: 617.4/72
• Soggetti: Bone regeneration; Joints - Diseases; Cartilage - Diseases; Animal cell biotechnology; Tissue culture
• Lingua di pubblicazione: Inglese
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Note generali: Description based upon print version of record.
• Nota di bibliografia: Includes bibliographical references and index.
• Nota di contenuto: TISSUE ENGINEERING OF CARTILAGE AND BONE; Contents; Participants; Chair's introduction; Tissue engineering of cartilage: do we need it, can we do it, is it good and can we prove it?; Discussion; Embryonic development and the principles of tissue engineering; Discussion; The fundamentals of tissue engineering: scaffolds and bioreactors; Discussion; Tissue-engineered versus native cartilage: linkage between cellular mechano-transduction and biomechanical properties; Discussion; From the preclinical model to the patient; Discussion; Mesenchymal stem cell therapy in joint disease; Discussion; Differentiated chondrocytes for cartilage tissue engineeringDiscussion; Mesenchymal stem cells and bioceramics: strategies to regenerate the skeleton; Discussion; Bone marrow stromal cells and their use in regenerating bone; Discussion; Studying the effect of different macrostructures on in vitro cell behaviour and in vivo bone formation ; using a tissue engineering approach; General discussion I; Cartilage repair with chondrocytes: clinical and cellular aspects; Discussion; Qualitative and quantitative in vivo assessment of articular cartilage using magnetic resonance imaging; Discussion; Hyaluronan-based scaffolds (Hyalograft® C) in the treatment of knee cartilage defects: preliminary clinical findingsQuantitative analysis of repair tissue biopsies following chondrocyte implantation; Discussion; General discussion II Tissue engineering using recombinant human BMP2; Final discussion and summing-up; Index of contributors; Subject index
• Sommario/riassunto: Tissue engineering takes advantages of the combined use of cultured living cells and three-dimensional scaffolds to reconstruct adult tissues that are absent or malfunctioning. This book brings together scientists and clinicians working on a variety of approaches for regenerating of damaged or lost cartilage and bone to assess the progress of this dynamic field.In its early days, tissue engineering was driven by material scientists who designed novel bio-resorbable scaffolds on which to seed cells and grow tissues. This ground-breaking work generated high expectations, but there have b