Clinical applications of TGF-[beta]

• Record Nr.: UNINA9910876900903321
• Pubbl/distr/stampa: Chichester ; ; New York, : Wiley, 1991
• ISBN: 1-282-34770-5; 9786612347702; 0-470-51406-X; 0-470-51407-8
• Descrizione fisica: 1 online resource (266 p.)
• Collana: Ciba Foundation symposium ; ; 157
• Altri autori (Persone): BockGregory; MarshJoan
• Disciplina: 615/.7
• Soggetti: Transforming growth factors-beta - Therapeutic use
• Lingua di pubblicazione: Inglese
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Note generali: Based on the Symposium on Clinical Applications of TGF-[beta], held at the Ciba Foundation, London, June 12-14, 1990.; Editors: Gregory R. Bock and Joan Marsh.; "A Wiley-Interscience publication."
• Nota di bibliografia: Includes bibliographical references and indexes.
• Nota di contenuto: CLINICAL APPLICATIONS OF TGF-B; Contents; Introduction; Multiple forms of TGF-B: distinct promoters and differential expression; TGF-B receptors; Mechanisms in TGF-B action; Regulation of epithelial proliferation by TGF-B; Latent forms of TGF-B: molecular structure and mechanisms of action; General discussion I : The role of TGF-B in the nervous system; TGF-B: a possible autocrine immune regulator; TGF-B and wound healing; General discussion II : A stimulatory effect of transforming growth factors on skin tumour devdopmcnt in vivo; The effects of TGF-B on bone; TGF-B1 and fibroblast growth factors selectively up-regulate tissue-specific fetal genes in cardiac muscle cellsEffects of TGF-Bs in the liver : cell proliferation and fibrogenesis; Role of TGF-B1 in experimental glomerulonephritis; The role of TGF-B in pulmonary fibrosis; In vivo and in vitro effects of TGF-B1 on normal and neoplastic haemopoiesis; Expression of TGF-B2 in human glioblastoma : a role in resistance to immune rejection?; Index of contributors; Subject index
• Sommario/riassunto: TGF-beta, originally identified as a transforming growth factor with ; similar properties, is now known to exist as a family of factors with similar properties. These factors promote cell proliferation in some tissue types or conditions and induce cell differentiation in others. Features the latest information on the TGF-beta family and its receptors. Describes correlations between TGF-beta and certain cancers, including glioblastomas. Also contains reports of preliminary investigations of clinical applications for TGF-beta in many diseases, including leukemia and its use to accelerate wound hea