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Record Nr. |
UNINA9910876518203321 |
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Titolo |
Novel infectious agents and the central nervous system |
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Pubbl/distr/stampa |
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Chichester ; ; New York, : Wiley, 1988 |
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ISBN |
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1-282-34597-4 |
9786612345975 |
0-470-51361-6 |
0-470-51362-4 |
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Descrizione fisica |
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1 online resource (290 p.) |
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Collana |
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Ciba Foundation symposium ; ; 135 |
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Disciplina |
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Soggetti |
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Central nervous system - Diseases - Etiology |
Scrapie |
Prions |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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"A Wiley-Interscience publication." |
Papers and discussions from the Symposium on Novel Infectious Agents and the Central Nervous System, held at the Ciba Foundation, London, June 30-July 2, 1987. |
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Nota di bibliografia |
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Includes bibliographies and indexes. |
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Nota di contenuto |
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NOVEL INFECTIOUS AGENTSANDTHE CENTRAL NERVOUS SYSTEM; Contents; Participants; Introduction; The clinical neurology and epidemiology of Creutzfeldt-Jakob disease, with special reference to iatrogenic cases; Neuropathology of unconventional virus infections: molecu lar pathology of spongiform change and amyloid plaque deposit ion; Pathogenesis of experimental scrapie; Genetic aspects of unconventional virus infections: the basis of the virino hypothesis; Genetic control of prion incubation period in mice; Developmental regulation of prion protein mRNA in brain |
Potential involvement of retroviral elements in human dementiasScrapie: a virus-induced amyloidosis of the brain; Scrapie-associated fibrils, PrP protein and the Sinc gene; A modified host protein model of scrapie; Properties of scrapie prion proteins in liposomes and amyloid rods; In vitro expression of cloned PrP cDNA derived from scrapie-infected mouse brain: lack of transmission of |
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scrapie infectivity; Search for a scrapie-specific nucleic acid: a progress report; Pathogenesis of amyloid formation in Alzheimer's disease, Down's syndrome and scrapie |
Novel mechanisms of degeneration of the central newous system - prion structure and biologyFinal general discussion; Summary; Index of contributors; Subject index |
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Sommario/riassunto |
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The term ``unconventional virus'' refers to virus-like agents that differ from conventional viruses in significant respects--resistance to agents that inactivate normal viruses, for example. Certain rare and fatal neurological disorders, such as the Creutzfeldt-Jacob syndrome and the Gerstmann-Straussler syndrome, are clearly produced by virus-like infectious agents, but the nature of these agents is not understood. This volume brings together the latest information on one such disease: Scrapie, a disease occurring in sheep. It discusses the nature of this infectious agent and insights gained |
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