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Record Nr. |
UNINA9910864197203321 |
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Autore |
Kattoor Jayasree |
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Titolo |
Bone Tumors : Evidence-Based Approach in Diagnosis and Management |
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Pubbl/distr/stampa |
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Singapore : , : Springer, , 2024 |
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©2024 |
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ISBN |
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Edizione |
[1st ed.] |
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Descrizione fisica |
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1 online resource (364 pages) |
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Altri autori (Persone) |
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Nair PSindhu |
GeotheJayasree |
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Disciplina |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Nota di contenuto |
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Intro -- Foreword -- Preface -- Acknowledgements -- Contents -- Abbreviations -- 1: Human Skeletal System -- 1.1 Bone Development -- 1.1.1 Intramembranous Ossification -- 1.1.2 Endochondral Ossification -- 1.2 Bone Growth -- 1.3 Classification of Bones -- 1.3.1 Long Bones -- 1.3.2 Short Bones -- 1.3.3 Flat Bones -- 1.3.4 Irregular Bones -- 1.4 Divisions of the Skeleton -- 1.5 Joints -- 1.6 Anatomy of Bones -- 1.6.1 Types of Bones -- 1.6.2 Bone Marrow -- 1.6.3 Periosteum -- 1.6.4 Bone Matrix -- 1.6.5 Cells of Bone -- 1.6.6 Microscopy of Bone -- 1.6.6.1 Lamellar Bone -- 1.6.6.2 Woven Bone -- 1.7 Cartilage -- 1.7.1 Types of Cartilage -- 1.7.2 Cartilage Cells -- References -- 2: Approach to Bone Tumours and Tumour-Like Lesions -- 2.1 Introduction -- 2.2 Evaluation of the Patient (Table 2.1) -- 2.2.1 History -- 2.2.2 Physical Examination -- 2.2.3 Imaging Modalities -- 2.2.4 Plain Radiograph -- 2.2.4.1 Location of Tumour/Lesion in the Bone -- 2.2.4.2 Pattern of Bone Destruction -- 2.2.4.3 Borders and Extent of the Lesion: Zone of Transition (ZOT) -- 2.2.4.4 Periosteal Reaction -- 2.2.4.5 Type of Matrix -- 2.2.4.6 Mono-Ostotic or Polyostotic -- 2.3 Laboratory Findings and Handling of Specimens -- 2.3.1 Bone Tumour Specimens -- 2.3.2 General Handling of Bone Tumour Specimens Before Dissection -- 2.3.3 Decalcification -- 2.3.4 Stains -- 2.3.5 Frozen Section -- 2.3.6 Handling of Biopsy and Curettage Specimen -- 2.3.7 Handling |
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of Amputation and Segmental Resection Specimen -- 2.3.8 Grading of Bone Sarcomas -- 2.4 Ancillary Investigations -- 2.4.1 Immunohistochemistry -- 2.4.2 Molecular Genetic Analysis -- 2.4.3 Other Ancillary Investigations -- References -- 3: Primary Bone Tumours -- 3.1 Syndromes Associated with Bone Tumours -- 3.2 Classification -- 3.3 Staging -- References -- 4: Cartilage Tumours. |
4.1 Benign Cartilage Tumours -- 4.1.1 Subungual Exostoses -- 4.1.1.1 Clinical -- 4.1.1.2 Radiology -- 4.1.1.3 Microscopy -- 4.1.1.4 Differential diagnosis -- 4.1.1.5 Molecular -- 4.1.1.6 Treatment and prognosis -- 4.1.2 Bizarre Parosteal Osteochondromatous Proliferation (BPOP or Nora Lesion) -- 4.1.2.1 Clinical -- 4.1.2.2 Radiology -- 4.1.2.3 Pathology -- 4.1.2.4 DD -- 4.1.2.5 Molecular -- 4.1.2.6 Treatment and Prognosis -- 4.1.3 Enchondroma and Periosteal Chondroma -- 4.1.3.1 Clinical -- 4.1.3.2 Radiology -- 4.1.3.3 Pathology -- 4.1.3.4 Differential Diagnosis -- 4.1.3.5 Treatment and Prognosis -- 4.1.4 Enchondroma Protuberans -- 4.1.4.1 Radiology -- 4.1.4.2 DD -- 4.1.5 Enchondromatosis (Multiple Chondromas) -- 4.1.6 Osteochondromas (OC) [43-60] -- 4.1.6.1 Clinical -- 4.1.6.2 Radiological features -- 4.1.6.3 Pathology -- 4.1.6.4 Differential Diagnosis -- 4.1.6.5 Molecular -- 4.1.6.6 Treatment and prognosis -- 4.1.7 Osteochondromatosis (Multiple Hereditary Exostoses) -- 4.1.8 Chondroblastoma (CB) -- 4.1.8.1 Clinical -- 4.1.8.2 Radiological features -- 4.1.8.3 Pathology -- 4.1.8.4 Differential Diagnosis -- 4.1.8.5 Cytogenetics and Molecular Diagnostic Pathology -- 4.1.8.6 Treatment and Prognosis -- 4.1.9 Chondromyxoid Fibroma (CMF) -- 4.1.9.1 Clinical -- 4.1.9.2 Radiological Features -- 4.1.9.3 Pathology -- 4.1.9.4 Differential Diagnosis -- 4.1.9.5 Molecular -- 4.1.9.6 Treatment and Prognosis -- 4.1.10 Osteochondromyxoma (OMX) -- 4.1.10.1 Clinical -- 4.1.10.2 Radiology -- 4.1.10.3 Pathology -- 4.1.10.4 IHC -- 4.1.10.5 Molecular -- 4.1.10.6 Treatment and Prognosis -- 4.2 Intermediate (Locally Aggressive) Tumours -- 4.2.1 Synovial Chondromatosis -- 4.2.2 Atypical cartilaginous tumour/grade I chondrosarcoma (ACT/CS 1) -- 4.2.2.1 Radiology -- 4.2.2.2 Pathology -- 4.2.2.3 Treatment and Prognosis -- 4.3 Malignant. |
4.3.1 Chondrosarcoma (CS) -- 4.3.1.1 Conventional CS -- Clinical -- Radiology -- Pathogenesis -- Pathology -- Grading in CS -- DD -- Treatment and Prognosis -- 4.3.2 Variants of Chondrosarcoma -- 4.3.2.1 Periosteal Chondrosarcoma -- 4.3.2.2 Clear Cell Chondrosarcoma (CCCS) -- Clinical -- Radiology -- Pathology -- Differential diagnosis -- Treatment and prognosis -- 4.3.2.3 Mesenchymal CS -- Clinical -- Radiology -- Microscopy -- IHC -- Molecular -- DD -- Treatment and prognosis -- 4.3.2.4 Dedifferentiated CS (DDCS) -- Clinical -- Radiology -- Pathogenesis -- Both conventional and dedifferentiated CS show identical TP53 and IDH mutations [124, 127]. Pathology -- DD -- Treatment and prognosis -- 4.3.3 Myxoid CS of Bone (MCS) -- 4.3.3.1 Clinical -- 4.3.3.2 Radiology -- 4.3.3.3 Pathology -- 4.3.3.4 IHC -- 4.3.3.5 DD -- 4.3.3.6 Treatment and prognosis -- 4.4 Other Chondroid Lesions Mistaken for Neoplasm -- 4.4.1 Exuberant Callus -- 4.4.2 Intervertebral Disc -- References -- Subungual Exostosis -- BPOP -- Enchondroma and Enchondromatosis -- Osteochondroma and Osteochondromatosis -- Chondroblastoma -- Chondromyxoid Fibroma -- Chondrosarcoma -- Periosteal Chondrosarcoma -- Dedifferentiated Chondrosarcoma -- Mesenchymal Chondrosarcoma -- Clear Cell Chondrosarcoma -- Myxoid Chondrosarcoma -- Osteochondromyxoma -- Exuberrant Callus -- Costochondral Junction -- Intervertebral Disc -- 5: Osteogenic Tumours -- 5.1 Terminology -- 5.2 Benign |
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and Intermediate Osteoid-Producing Tumours -- 5.2.1 Osteoma -- 5.2.1.1 Clinical -- 5.2.1.2 Radiology -- 5.2.1.3 Pathology -- 5.2.1.4 Treatment -- 5.2.2 Osteoid Osteoma (OO) -- 5.2.2.1 Clinical -- 5.2.2.2 Radiology -- 5.2.2.3 Pathology -- 5.2.2.4 Molecular Findings -- 5.2.2.5 Treatment and Prognosis -- 5.2.3 Osteoblastoma (OB) -- 5.2.3.1 Clinical -- 5.2.3.2 Radiology -- 5.2.3.3 Pathology. |
5.2.3.4 IHC -- 5.2.3.5 Molecular -- 5.2.3.6 DD -- 5.2.3.7 Treatment and Prognosis -- 5.3 Malignant tumours-Osteosarcoma -- 5.3.1 Clinical -- 5.3.2 Radiology -- 5.3.3 Pathology -- 5.3.4 Immunohistochemistry -- 5.3.5 Molecular -- 5.3.6 Grading of Osteosarcoma -- 5.3.7 Morphological Subtypes -- 5.3.7.1 Low-Grade Central Osteosarcoma (LGCOS) -- Clinical -- Radiology -- Pathology -- IHC -- Molecular -- DD -- Treatment and Prognosis -- 5.3.7.2 Conventional Osteosarcoma (COS) -- 5.3.7.3 Telangiectatic Osteosarcoma (TAEOS) -- Radiology -- Pathology -- 5.3.7.4 Small Cell Osteosarcoma (SCOS) -- 5.3.7.5 Other Unusual Morphological Variants -- Giant Cell-Rich OS -- Differential Diagnosis -- Epithelioid OS -- Osteoblastoma-Like OS -- Chondromyxoid Fibroma-Like OS -- Chondroblastoma-Like OS -- Clear Cell OS -- MFH-Like OS -- 5.3.8 Surface Osteosarcomas -- 5.3.8.1 Parosteal OS -- Radiology -- Pathology -- IHC -- Molecular -- Differential Diagnosis -- Treatment -- 5.3.8.2 Periosteal Osteosarcoma -- Radiology -- Pathology -- DD -- Molecular -- Treatment and Prognosis -- 5.3.8.3 High-Grade Surface Osteosarcom -- Pathology -- Treatment and Prognosis -- 5.3.9 Osteosarcoma of Jaw -- 5.3.10 Secondary Osteosarcoma -- 5.3.11 Composite Sarcoma of Bone -- 5.3.12 Multicentric Osteosarcoma -- 5.3.13 Mimickers of Osteosarcoma -- 5.3.14 Osteosarcomatous Areas in Other Tumours -- 5.3.15 Treatment and Prognosis of Osteosarcoma -- 5.3.15.1 Assessment of the Effect of Chemotherapy -- 5.3.15.2 Prognosis -- 5.3.16 Cytogenetic [150] and Molecular [103, 124]findings in OS (Table 5.14) -- 5.4 Other Osteoid-Producing Lesions Mimicking Tumour -- 5.4.1 Heterotopic Ossification (Myositis Ossificans) -- 5.4.1.1 Clinical -- 5.4.1.2 Radiology -- 5.4.1.3 Pathology -- 5.4.1.4 Treatment and prognosis -- 5.4.2 Bone Island -- 5.4.2.1 Radiology. |
5.4.2.2 Pathology -- 5.4.2.3 DD -- 5.4.3 For stress Fracture, Insufficiency Fracture and Avulsion Injury, see Chap. 17. -- References -- Osteoma, Osteoid Osteoma, Osteoblastoma -- Osteosarcoma -- Low Grade Central OS -- Small Cell Osteosarcoma -- Parosteal -- Periosteal OS -- High Grade Surface OS -- Secondary OS -- Composite Sarcoma of Bone -- Myositis Ossificans -- Bone Island -- 6: Fibrous Tumours and Lesions of Bone -- 6.1 Fibrogenic Tumours: Classification [59, 62] -- 6.2 Desmoplastic Fibroma -- 6.2.1 Radiology -- 6.2.2 Pathology -- 6.2.3 Treatment and Prognosis -- 6.3 Other Benign Fibrous Tumours of Bone -- 6.3.1 Fibrous Dysplasia (FD) -- 6.3.1.1 Clinical -- 6.3.1.2 Radiology -- 6.3.1.3 Pathology -- 6.3.1.4 Differential diagnosis -- 6.3.1.5 Molecular -- 6.3.1.6 Treatment and Prognosis -- 6.3.1.7 Malignancy in Fibrous Dysplasia -- 6.3.2 Osteofibrous Dysplasia (OFD) -- 6.3.2.1 Clinical -- 6.3.2.2 Radiology -- 6.3.2.3 Pathology -- 6.3.3 Periosteal Desmoid -- 6.3.4 Fibrocartilaginous Mesenchymoma -- 6.3.5 Myofibroma (Infantile Myofibromatosis) -- 6.4 Malignant Tumours -- 6.4.1 Fibrosarcoma (FS) -- 6.4.1.1 Clinical -- 6.4.1.2 Radiology -- 6.4.1.3 Pathology -- 6.4.1.4 DD -- 6.4.1.5 Treatment and Prognosis -- 6.4.2 Sclerosing Epithelioid Fibrosarcoma of Bone -- 6.4.2.1 Clinical -- 6.4.2.2 Radiology -- 6.4.2.3 Pathology -- 6.4.2.4 IHC and Molecular -- 6.4.2.5 Treatment and Prognosis -- 6.5 Fibrohistiocytic Tumours -- 6.5.1 Malignant -- 6.5.1.1 Undifferentiated Pleomorphic Sarcoma (UPS) -- |
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Clinical -- Radiology -- Pathology -- DD -- Treatment and Prognosis -- References -- Desmoplastic Fibroma -- Fibrous Dysplasia -- Osteo Fibrous Dysplasia -- Myofibroma -- Fibrosarcoma and Undifferentiated Sarcoma -- 7: Giant Cell-Rich Tumours -- 7.1 Classification of Osteoclastic Giant Cell-Rich tumours [60] -- 7.2 Aneurysmal Bone Cyst (ABC). |
7.2.1 Clinical. |
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