| |
|
|
|
|
|
|
|
|
1. |
Record Nr. |
UNINA9910688344303321 |
|
|
Autore |
Erich Kombrink |
|
|
Titolo |
When Chemistry Meets Biology - Generating Innovative Concepts, Methods and Tools for Scientific Discovery in the Plant Sciences |
|
|
|
|
|
|
|
Pubbl/distr/stampa |
|
|
|
|
|
|
Descrizione fisica |
|
1 online resource (146 p.) |
|
|
|
|
|
|
Collana |
|
Frontiers Research Topics |
|
|
|
|
|
|
Soggetti |
|
|
|
|
|
|
Lingua di pubblicazione |
|
|
|
|
|
|
Formato |
Materiale a stampa |
|
|
|
|
|
Livello bibliografico |
Monografia |
|
|
|
|
|
Sommario/riassunto |
|
Biologically active small molecules have increasingly been applied in plant biology to dissect and understand biological systems. This is evident from the frequent use of potent and selective inhibitors of enzymes or other biological processes such as transcription, translation, or protein degradation. In contrast to animal systems, which are nurtured from drug research, the systematic development of novel bioactive small molecules as research tools for plant systems is a largely underexplored research area. This is surprising since bioactive small molecules bear great potential for generating new, powerful tools for dissecting diverse biological processes. In particular, when small molecules are integrated into genetic strategies (thereby defining "chemical genetics"), they may help to circumvent inherent problems of classical (forward) genetics. There are now clear examples of important, fundamental discoveries originating from plant chemical genetics that demonstrate the power, but not yet fully exploited potential, of this experimental approach. These include the unraveling of molecular mechanisms and critical steps in hormone signaling, activation of defense reactions and dynamic intracellular processes. The intention of this Research Topic of Frontiers in Plant Physiology is to summarize the current status of research at the interface between chemistry and biology and to identify future research challenges. The research topic covers diverse aspects of plant chemical biology, including the identification of bioactive small molecules through screening processes |
|
|
|
|
|
|
|
|
|
|
from chemical libraries and natural sources, which rely on robust and quantitative high-throughput bioassays, the critical evaluation and characterization of the compound's activity (selectivity) and, ultimately, the identification of its protein target(s) and mode-of-action, which is yet the biggest challenge of all. Such well-characterized, selective chemicals are attractive tools for basic research, allowing the functional dissection of plant signaling processes, or for applied purposes, if designed for protection of crop plants from disease. New methods and data mining tools for assessing the bioactivity profile of compounds, exploring the chemical space for structure-function relationships, and comprehensive chemical fingerprinting (metabolomics) are also important strategies in plant chemical biology. In addition, there is a continuing need for diverse target-specific bioprobes that help profiling enzymatic activities or selectively label protein complexes or cellular compartments. To achieve these goals and to add suitable probes and methods to the experimental toolbox, plant biologists need to closely cooperate with synthetic chemists. The development of such tailored chemicals that beyond application in basic research can modify traits of crop plants or target specific classes of weeds or pests by collaboration of applied and academic research groups may provide a bright future for plant chemical biology. The current Research Topic covers the breadth of the field by presenting original research articles, methods papers, reviews, perspectives and opinions. |
|
|
|
|
|
|
|
|
|
|
|
|
|
2. |
Record Nr. |
UNINA9910861945303321 |
|
|
Autore |
Sato Jin |
|
|
Titolo |
The Semantics of Development in Asia : Exploring ‘Untranslatable’ Ideas Through Japan / / edited by Jin Sato, Soyeun Kim |
|
|
|
|
|
|
|
Pubbl/distr/stampa |
|
|
Singapore : , : Springer Nature Singapore : , : Imprint : Springer, , 2024 |
|
|
|
|
|
|
|
ISBN |
|
|
|
|
|
|
Edizione |
[1st ed. 2024.] |
|
|
|
|
|
Descrizione fisica |
|
1 online resource (250 pages) |
|
|
|
|
|
|
Collana |
|
The University of Tokyo Studies on Asia, , 2731-7641 |
|
|
|
|
|
|
Altri autori (Persone) |
|
|
|
|
|
|
Disciplina |
|
|
|
|
|
|
Soggetti |
|
Economic development |
Asia - Politics and government |
Ethnology - Asia |
Culture |
Philosophy, Japanese |
International relations |
Business |
Asia |
Development Studies |
Asian Politics |
Asian Culture |
Japanese Philosophy |
International Relations |
Asian Business |
|
|
|
|
|
|
|
|
Lingua di pubblicazione |
|
|
|
|
|
|
Formato |
Materiale a stampa |
|
|
|
|
|
Livello bibliografico |
Monografia |
|
|
|
|
|
Nota di contenuto |
|
Chapter 1 Civil Engineering -- Chapter 2 Hands-on Approach -- Chapter 3 Development-Import Scheme -- Chapter 4 Human Resources Development -- Chapter 5 Endogenous Development. |
|
|
|
|
|
|
|
|
Sommario/riassunto |
|
This open access book explores Japanese involvement in Asian development through selected development ideas and lexemes that are widely regarded in Japan as 'untranslatable' into other languages. Each chapter traces the genealogy of locally nuanced development ideas and lexemes in Japan and the process by which they have spread across Asia and beyond through Japan's development cooperation. The |
|
|
|
|
|
|
|
|
|
|
Semantics of Development in Asia critically examines the diverse (Western and non-Western) roots of Japanese development ideas and lexemes and their shifting semantics, shaped by the ever-changing national/international political economies and dominant development thinking of different eras. The volume contributes to a more pluriversal approach to knowledge production in development studies through its in-depth examination of vernacular Japanese ideas. This book is useful to researchers, students and teachers in the fields of Asian studies, development studies andinternational relations. It is also of value to policymakers and practitioners whose professional interests include development cooperation by, and with, Asian countries. |
|
|
|
|
|
| |