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1. |
Record Nr. |
UNINA9910143176103321 |
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Autore |
Lee Mike S. <1960-> |
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Titolo |
LC/MS applications in drug development [[electronic resource] /] / Mike S. Lee |
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Pubbl/distr/stampa |
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New York, : J. Wiley & Sons, c2002 |
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ISBN |
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1-280-36642-7 |
9786610366422 |
0-470-35636-7 |
0-471-45930-5 |
0-471-21881-2 |
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Descrizione fisica |
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1 online resource (257 p.) |
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Collana |
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Wiley-Interscience series on mass spectrometry |
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Disciplina |
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Soggetti |
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Drug development - Methodology |
Drugs - Analysis |
Liquid chromatography |
Mass spectrometry |
Combinatorial chemistry |
Gel permeation chromatography |
Drugs - Testing - Methodology |
Electronic books. |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references (p. 205-234) and index. |
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Nota di contenuto |
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LC/MS APPLICATIONS IN DRUG DEVELOPMENT; CONTENTS; Preface; Acknowledgments; 1. Introduction; Emerging Analytical Needs; Integration of LC/MS into Drug Development; Partnerships and Acceptance; Overview; 2. Drug Development Overview; Analysis Perspectives; The Four Stages of Drug Development; Drug Discovery; Preclinical Development; Clinical Development; Manufacturing; 3. Accelerated Drug Development; Accelerated Development Strategies; Quantitative and Qualitative Process Elements; Quantitative Process Pipeline; Qualitative Process Pipeline; Motivating Factors |
Analysis Opportunities for Accelerated DevelopmentFull-Time |
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Equivalent; Sample Throughput Model; Elimination Model; Rate-Determining Event Model; Accelerated Development Perspectives; 4. LC/MS Development; The Elements of LC/MS Application; HPLC; Mass Spectrometry; LC/MS Interface; LC/MS Growth; 5. Strategies; Standard Methods; Template Structure Identification; Databases; Screening; Integration; Miniaturization; Parallel Processing; Visualization; Automation; Summary; 6. LC/MS Applications; Drug Discovery; Proteomics; Protein Expression Profiling; Quantitation; Glycoprotein Mapping |
Natural Products DereplicationLead Identification Screening; Bioaffinity Screening; Combinatorial Library Screening; Open-Access LC/MS; Structure Confirmation; High Throughput; Purification; Combinatorial Mixture Screening; In Vivo Drug Screening; Pharmacokinetics; In Vitro Drug Screening; Metabolic Stability Screening; Membrane Permeability; Drug-Drug Interaction; Metabolite Identification; Preclinical Development; Metabolite Identification; Impurity Identification; Degradant Identification; Clinical Development; Quantitative Bioanalysis-Selected Ion Monitoring |
Quantitative Bioanalysis-Selected Reaction MonitoringQuantitative Bioanalysis-Automated Solid-Phase Extraction; Quantitative Bioanalysis-Automated On-Line Extraction; Metabolite Identification; Degradant Identification; Manufacturing; Impurity Identification Using Data-Dependent Analysis; Peptide Mapping in Quality Control; Patent Protection; 7. Future Applications and Prospects; Workstations; Multidimensional Analysis; Miniaturization; Information Management; Strategic Outsourcing; Summary; 8. Perspectives on the Future Growth of LC/MS; 9. Conclusions; Glossary; References; Index |
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Sommario/riassunto |
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Breakthroughs in combinatorial chemistry and molecular biology, as well as an overall industry trend toward accelerated development, mean the rate of sample generation now far exceeds the rate of sample analysis in the pursuit of producing new and better pharmaceuticals. LC/MS is an analytical tool that helps the researcher identify the most promising sample early in the selection process, effectively creating a shortcut to finding new drugs. This book is the first to describe LC/MS applications within the context of drug development, including the discovery, preclinical, clinical, and manufac |
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2. |
Record Nr. |
UNINA9910856994703321 |
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Autore |
Fitz Earl E |
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Titolo |
Clarice Lispector : From Brazil to the World |
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Pubbl/distr/stampa |
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West Lafayette, IN : , : Purdue University Press, , 2024 |
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©2024 |
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ISBN |
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9781612499437 |
1612499430 |
9781612499444 |
1612499449 |
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Edizione |
[1st ed.] |
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Descrizione fisica |
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1 online resource (241 pages) |
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Collana |
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Purdue Studies in Romance Literatures Series |
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Disciplina |
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Soggetti |
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Litterature bresilienne - 20e siecle - Histoire et critique |
Brazilian literature - 20th century - History and criticism |
Electronic books. |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Nota di bibliografia |
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Includes bibliographical references and index. |
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Nota di contenuto |
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Acknowledgments -- Introduction -- Clarice and politics -- Clarice and humor -- Clarice, writing, and language -- Clarice and eroticism -- Clarice and God -- Clarice, world literature, and translation -- Conclusion -- Notes -- Works cited -- Index |
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Sommario/riassunto |
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Clarice Lispector: From Brazil to the World explains why the Brazilian master was so transformative of modern Brazilian literature and why she has become such a celebrity in the world literature arena. This book also shows why Lispector is not one writer, as many think, but many writers. By offering close readings of her novels, stories, and nonfiction pieces, Earl E. Fitz shows the diverse sides of her literary world. Chapters cover Lispector's devotion to language and its connection to identity; her political engagement; and her humor, eroticism, and struggle with the concept of God. The last chapter seeks to explain why this most singular of modern Brazilian writers commands such a passionate global following. |
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