Intro -- Foreword 1 -- Foreword 2 -- References -- Preface -- References -- Contents -- Contributors -- I: Basic Principles in the Assessment and Treatment of Late-Life Neuropsychiatric Syndromes -- 1: Physiology and Pathology of Aging -- 1.1 Background -- 1.1.1 Normal Versus Normative Aging -- 1.1.2 Loss of Resilience -- 1.1.3 Construct of Frailty -- 1.1.4 Multimorbidity -- Prevalence of Multimorbidity in Older Adults -- Physiological Mechanisms Underlying Multimorbidity and Functional Decline -- The Aging Effects of Chronic Inflammation -- Chronic Inflammation and Physical Performance -- Inflammation and Geriatric Depression -- 1.1.5 Telomere Length, Inflammation, and Multimorbidity -- Significance of Telomeres and Aging -- 1.1.6 Aging in Individual Organ Systems and Implications for Disease and Treatment -- The Aging Nervous System -- Morphological and Metabolic Changes in the Brain -- Cognitive Changes with Aging -- Changes in the Peripheral Nervous System -- Aging and the Perception of Pain -- 1.1.7 Age-Related Changes in the Heart -- Ventricular Function -- Atrial Fibrillation and Cognitive Function -- Autonomic Changes -- Orthostatic Hypotension -- Aging of the Cardiac Conduction System -- 1.1.8 The Aging Lung -- 1.1.9 The Aging Endocrine System -- Thyroid Disorders -- Sex Hormones, Aging, and Cognition -- Estrogen Replacement |