1.

Record Nr.

UNINA9910841726003321

Titolo

Plasminogen-related growth factors [[electronic resource] /] / [editors, Gregory R. Bock (organizer) and Jamie A. Goode]

Pubbl/distr/stampa

Chichester ; ; New York, : Wiley, 1997

ISBN

1-282-45544-3

9786612455445

0-470-51545-7

0-470-51547-3

Descrizione fisica

1 online resource (272 p.)

Collana

Ciba Foundation symposium ; ; 212

Altri autori (Persone)

BockGregory

GoodeJamie

Disciplina

571.8/4

571.84

573.15921

Soggetti

Growth factors

Plasminogen

Plasminogen activators

Lingua di pubblicazione

Inglese

Formato

Materiale a stampa

Livello bibliografico

Monografia

Note generali

Symposium on plasminogen-related growth factors was held at the Ciba Foundation, London, Apr. 8-10, 1997.

Nota di bibliografia

Includes bibliographical references and indexes.

Nota di contenuto

PLASMINOGEN-RELATED GROWTH FACTORS; Contents; Participants; Chairman's introduction; Evolution of vertebrate fibrin formation and the process of its dissolution; Evolution of plasminogen-related growth factors (HGF/SF and HGFl/MSP); General discussion I; The kringle domains of human plasminogen; Structure and function of microplasminogen: reconstitution of microplasminogen and microplasmin from isolated fragments; Domain structure of hepatocyte growth factor/scatter factor (HGF/SF); General discussion II; Plasminogen/plasminogen activator and growth factor activation

Met-HGF/SF: tumorigenesis, invasion and metastasisScatter factor receptors are key players in a unique multistep program leading to invasive growth; General discussion III; Competence for neural induction: HGF/SF, HGFl/MSP and the c-Met receptor; The functions of HGF/SF and its receptor, the c-Met tyrosine kinase, in mammalian



development; Biological aspects of macrophage- stimulating protein (MSP) and its receptor; HGF: its organotrophic role and therapeutic potential; HGF/SF in angiogenesis; Role of HGF/SF and c-Met in morphogenesis and metastasis of epithelial cells; General discussion IV

Chairman's summing-upIndex of contributors; Subject index

Sommario/riassunto

A timely volume dealing with the evolutionary and structural links between the clotting and fibrinolytic proteins and plasminogen-related growth factors. The role of individual domains for enzymatic proteins and plasminogen-related growth factors is also comprehensively examined.