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Record Nr. |
UNINA9910841344003321 |
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Titolo |
Mucus hypersecretion in respiratory disease [[electronic resource]] |
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Pubbl/distr/stampa |
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Chichester, West Sussex, England ; ; Hoboken, NJ, USA, : Wiley, 2002 |
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ISBN |
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1-280-27111-6 |
9786610271115 |
0-470-66827-X |
0-470-85929-6 |
0-470-86079-0 |
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Descrizione fisica |
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1 online resource (304 p.) |
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Collana |
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Novartis Foundation symposium ; ; 248 |
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Altri autori (Persone) |
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Disciplina |
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Soggetti |
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Mucous membrane |
Respiratory organs - Diseases |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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"Editors, Derek J. Chadwick and Jamie A. Goode"--P. [v]. |
"Symposium on Mucus Hypersecretion in Respiratory Disease, held at the Novartis Foundation, London, 26-28 February 2002"--P. [v]. |
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Nota di bibliografia |
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Includes bibliographical references and indexes. |
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Nota di contenuto |
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MUCUS HYPERSECRETION IN RESPIRATORY DISEASE; Contents; Participants; Chair's introduction; Epidemiological studies in mucus hypersecretion; Discussion; Post-secretory fate of host defence components in mucus; Discussion; Mechanisms of submucosal gland morphogenesis in the airway; Discussion; Mucin-producing elements and inflammatory cells; Discussion; Respiratory tract mucins: structure and expression patterns; Discussion; Development and validation of a lectin-based assay for the quantitation of rat respiratory mucin; Discussion; Regulation of mucin secretion from in vitro cellular models |
DiscussionOscillations of pH inside the secretory granule control the gain of Ca(2+) release for signal transduction in goblet cells exocytosis; Discussion; A calcium-activated chloride channel blocker inhibits goblet cell metaplasia and mucus overproduction; Discussion; Mechanisms by which Gram-positive bacteria and tobacco smoke stimulate mucin induction through the epidermal growth factor receptor (EGFR); Discussion; Non-allergic models of mucous cell |
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metaplasia and mucus hypersecretion in rat nasal and pulmonary airways; Discussion |
Cytokine regulation of mucus production in a model of allergic asthmaDiscussion; The role of apoptotic regulators in metaplastic mucous cells; Discussion; Current and future therapies for airway mucus hypersecretion; Discussion; Clinical evaluation of new therapies for treatment of mucus hypersecretion in respiratory diseases; Discussion; Final general discussion; Index of contributors; Subject index |
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Sommario/riassunto |
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A number of chronic respiratory diseases including chronic bronchitis, asthma, cystic fibrosis and bronchiectasis are characterized by mucus hypersecretion. Following damage to the airway epithelium, a repair process of dedifferentiation, regenerative proliferation and redifferentiation takes place that is invariably accompanied by mucus hypersecretion as a key element in the host defence mechanism. In chronic respiratory diseases, however, excessive mucus production leads to a pathological state with increased risk of infection, hospitalization and morbidity. An understanding of the mechanism |
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