| |
|
|
|
|
|
|
|
|
1. |
Record Nr. |
UNINA9910841169403321 |
|
|
Autore |
Zur Hausen Harald |
|
|
Titolo |
Infections causing human cancer / / Harald zur Hausen ; with a contribution of James G. Fox, Timothy C. Wang and Julie Parsonnet |
|
|
|
|
|
|
|
Pubbl/distr/stampa |
|
|
Weinheim, : Wiley-VCH |
|
Chichester, : John Wiley [distributor], c2006 |
|
|
|
|
|
|
|
|
|
ISBN |
|
1-281-08786-6 |
1-282-13982-7 |
9786612139826 |
9786611087869 |
3-527-60931-8 |
3-527-60929-6 |
|
|
|
|
|
|
|
|
Descrizione fisica |
|
1 online resource (533 p.) |
|
|
|
|
|
|
Disciplina |
|
|
|
|
|
|
Soggetti |
|
Viral carcinogenesis |
Microbial carcinogenesis |
|
|
|
|
|
|
|
|
Lingua di pubblicazione |
|
|
|
|
|
|
Formato |
Materiale a stampa |
|
|
|
|
|
Livello bibliografico |
Monografia |
|
|
|
|
|
Note generali |
|
Description based upon print version of record. |
|
|
|
|
|
|
Nota di bibliografia |
|
Includes bibliographical references and index. |
|
|
|
|
|
|
Nota di contenuto |
|
Infections Causing Human Cancer; Table of Contents; Preface; 1 Historical Review; 1.1 The Early Period (1898-1911); 1.2 Frustration and Successes (1912-1950); 1.3 The Period from 1950 to 1965; 1.4 A First Human Tumorvirus?; 1.5 The Difficult 1970s; 1.6 The Re-Emergence of a Concept; References; 2 The Quest for Causality; 2.1 Infectious Agents as Direct Carcinogens; 2.2 Infectious Agents as Indirect Carcinogens; 2.2.1 Induction of Chromosomal Aberrations; References; 3 Tumors Linked to Infections: Some General Aspects; 3.1 Tumor Types Linked to Infections |
3.2 Global Contributions of Infections to Human Cancers3.3 Host Interactions with Potentially Carcinogenic Infections: The CIF Concept; 3.3.1 The CIF-I Cascade; 3.3.2 The CIF-II Cascade; 3.3.3 The CIF-III Cascade; References; 4 Herpesviruses and Oncogenesis; References; 4.1 Alphaherpesvirinae; 4.1.1 Herpes Simplex Viruses Types 1 and 2; 4.1.2 Varicella-Zoster Virus; References; 4.2 Betaherpesvirinae; 4.2.1 Human Cytomegalovirus; 4.2.2 Human Herpesvirus Type 6; References; |
|
|
|
|
|
|
|
|
|
|
|
4.3 Gammaherpesvirinae (Lymphocryptoviruses); 4.3.1 Epstein-Barr Virus |
4.3.1.1 Characterization of the Virus, and its Biological Properties4.3.1.2 EBV Gene Products in Latent Infection; 4.3.1.3 Transforming Properties of EBV and Tumor Induction in Animals; 4.3.1.4 Various Stages of Epstein-Barr Viral Latency; 4.3.1.5 EBV in Infectious Mononucleosis; 4.3.1.6 EBV in X-Chromosome-Linked Lymphoproliferative Disease; 4.3.1.7 EBV in Immunoblastic Lymphoma; 4.3.1.8 EBV in Burkitt's Lymphoma; 4.3.1.9 EBV in Nasopharyngeal Carcinoma; 4.3.1.10 EBV in Hodgkin's Disease; 4.3.1.11 EBV in Gastric and Esophageal Carcinomas; 4.3.1.12 EBV in NK/T-Cell Lymphomas |
4.3.1.13 EBV and Other Human CancersReferences; 4.4 Rhadinoviruses; 4.4.1 Human Herpesvirus Type 8 (HHV-8, Kaposi's sarcoma-associated herpesvirus); 4.4.1.1 Historical Background; 4.4.1.2 Epidemiology and Mode of Transmission; 4.4.1.3 Pathogenesis: Other Diseases Associated with HHV-8 Infections; 4.4.1.4 Viral Genes Expressed in Viral Latency; 4.4.1.5 Cellular Genes Regulating Viral Latency; 4.4.1.6 Interaction Between HIV and HHV-8; 4.4.1.7 Viral Homologues to Host Cell Genes and Evasion from the Host's Immune Mechanisms; 4.4.1.8 HHV-8-Related Herpesviruses in Nonhuman Primates |
4.4.2 Marek's Disease of ChickensReferences; 5 Papillomavirus Infections: A Major Cause of Human Cancers; 5.1 Introduction; 5.1.1 Structure of the Viral Particle, Transcriptional Regulation, and Taxonomy; 5.1.2 Transmission and Natural History of Papillomavirus Infections; 5.1.3 Functions of Viral Proteins; 5.1.3.1 E6; 5.1.3.2 E6*; 5.1.3.3 E7; 5.1.3.4 E5; 5.1.3.5 E1; 5.1.3.6 E2; 5.1.3.7 E4; 5.2 The Concept of Cellular Interfering Cascades: Immunological, Intracellular and Paracrine Host Factors Influencing Viral Oncogene Expression or Function; 5.2.1 Immunological Control |
5.2.2 CIF-I: Recognition System and its Disturbance |
|
|
|
|
|
|
Sommario/riassunto |
|
Written by the Nobel Prize Laureate in Physiology or Medicine 2008 In the 1970s, the author of this work and his co-workers initially found Epstein-Barr virus DNA in Burkitt's lymphomas and nasopharyngeal cancer and made the connection between HPV infection and cervical cancer. It was also during this period and subsequently that scientists all over the world discovered tumor-inducing bacteria, viruses, parasites, and protozoa, opening up entirely new prospects for the prevention and treatment of infection-induced cancer by vaccination. Adopting a unifying concept and a consistent s |
|
|
|
|
|
|
|
| |