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Record Nr. |
UNINA9910831177003321 |
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Titolo |
Growth factors and psychiatric disorders [[electronic resource]] |
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Pubbl/distr/stampa |
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Chichester, UK ; ; Hoboken, NJ, : John Wiley & Sons, 2008 |
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ISBN |
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1-281-32226-1 |
9786611322267 |
0-470-75125-8 |
0-470-75126-6 |
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Descrizione fisica |
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1 online resource (260 p.) |
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Collana |
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Novartis Foundation symposium ; ; 289 |
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Altri autori (Persone) |
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Disciplina |
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Soggetti |
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Growth factors |
Mental illness - Genetic aspects |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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"Editors: Derek J. Chadwick (organizer) and Jamie Goode"--P. v. |
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Nota di bibliografia |
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Includes bibliographical references and indexes. |
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Nota di contenuto |
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GROWTH FACTORS AND PSYCHIATRIC DISORDERS; Contents; Chair's introduction; Phenomenology, aetiology and treatment of schizophrenia; DISCUSSION; Genetic variants in major depression; DISCUSSION; Neurotrophins in depression and antidepressant effects; DISCUSSION; Genetics of bipolar disorder: focus on BDNF Val66Met polymorphism; DISCUSSION; Mechanisms of neuregulin action; DISCUSSION; General discussion I; The fibroblast growth factor family and mood disorders; DISCUSSION; Trajectories of anatomic brain development as a phenotype; DISCUSSION |
Cell biology of BDNF and its relevance to schizophreniaDISCUSSION; Functions and mechanisms of BDNF mRNA trafficking; DISCUSSION; Hippocampal neurogenesis and depression; DISCUSSION; Neuregulins and neuronal plasticity: possible relevance in schizophrenia; DISCUSSION; Impact of genetic variant BDNF (Val66Met) on brain structure and function; DISCUSSION; General discussion II; Growth and schizophrenia: aetiology, epidemiology and epigenetics; DISCUSSION; What can we learn from the disrupted in schizophrenia 1 interactome: lessons for target identification and disease biology?; DISCUSSION |
Neurotrophins and cytokines in neuronal plasticityDISCUSSION; Closing |
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remarks; Contributor Index; Subject Index |
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Sommario/riassunto |
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The recent identification of susceptibility genes for schizophrenia, depression and learning and memory dysfunction suggest that psychiatric disorders may be influenced by a small number of genes with multiple actions. This is the first book to investigate the role of growth factors in these disorders, which should provide clues to the underlying biochemical mechanisms. For example, recent studies have substantiated the provocative finding that neuregulin 1 (NRG1)is a candidate gene for schizophrenia. Neuregulin and its receptors, the ErbB tyrosine kinases, are essential for development |
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