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1. |
Record Nr. |
UNINA9910831095603321 |
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Titolo |
Preparative enantioselective chromatography [[electronic resource] /] / edited by Geoffrey B Cox |
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Pubbl/distr/stampa |
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Ames, Iowa, : Blackwell Pub., 2005 |
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ISBN |
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1-280-19691-2 |
9786610196913 |
0-470-98842-8 |
1-4051-4471-8 |
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Edizione |
[1st ed.] |
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Descrizione fisica |
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1 online resource (346 p.) |
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Altri autori (Persone) |
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Disciplina |
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Soggetti |
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Liquid chromatography |
Enantiomers - Separation |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references and index. |
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Nota di contenuto |
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Preparative Enantioselective Chromatography; Contents; Contributors; Preface; 1. Chiral chromatography in support of pharmaceutical process research; 1.1 Introduction; 1.2 A brief introduction to chirality; 1.3 Why chirality is important; 1.4 Accessing enantiopurity: a brief overview of approaches; 1.4.1 Enantiopure starting materials: the chiral pool; 1.4.2 Removable enantioenriched auxiliaries; 1.4.3 Enantioselective catalysis; 1.4.4 Resolution technologies: introduction; 1.4.5 Chromatographic productivity is the key metric for preparative chromatography |
1.4.6 Stationary phases for preparative chiral chromatography1.4.7 Advantages of preparative chiral chromatography over other approaches for accessing enantiopure materials; 1.4.8 Simulated moving bed enantioseparation; 1.5 Green enantioseparation; 1.6 What is the appropriate role of preparative chromatography in organic synthesis?; 1.7 Fording the river at the easiest point: some observations on the appropriate placement of a chromatographic resolution within a chiral synthesis; 1.8 Origins of preparative chiral chromatography |
1.9 Practical tips for preparative chromatographic enantioseparation1. |
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10 Conclusion; 2. Introduction to preparative chromatography; 2.1 Introduction; 2.2 Adsorption isotherms; 2.2.1 The simple case - the Langmuir isotherm; 2.2.2 Other isotherms; 2.2.3 Competitive isotherms; 2.3 Kinetics; 2.4 Metrics for preparative operations; 2.4.1 Throughput; 2.4.2 Production rate; 2.4.3 Productivity; 2.4.4 Specific productivity; 2.4.5 Cost; 2.5 The influence of chromatographic parameters on preparative chromatography; 2.5.1 Effect of particle size on preparative performance; 2.5.2 Effects of pressure |
2.5.3 Effects of column efficiency2.5.4 Effect of column length; 2.5.5 The effects of selectivity; 2.6 Economics of preparative separations; 2.6.1 Point of insertion of the chromatographic resolution in the synthetic route; 3 Chiral stationary phases for preparative enantioselective chromatography; 3.1 Summary; 3.2 Introduction; 3.3 Historical development of CSPs for preparative chromatography; 3.4 Preparative CSPs; 3.4.1 Classification of CSPs; 3.4.2 Polymeric phases; 3.4.3 Brush-type CSPs; 3.4.4 Chiral phases for ligand-exchange chromatography; 3.4.5 Imprinted phases |
3.5 Chemical and physical properties of CSPs3.5.1 Loading capacity; 3.5.2 Chemical and physical stability; 3.5.3 Solubility of the chiral solute; 3.6 New and future developments in the field of preparative CSPs; 3.6.1 CSPs with improved loading capacity; 3.6.2 CSPs with improved selectivity; 3.6.3 Immobilised polysaccharide-based CSPs; 3.7 Conclusion; 4 Method development for preparative enantioselective chromatography; 4.1 Introduction; 4.2 Chiral stationary phases for enantioselective chromatography; 4.3 Screening and optimisation strategy for preparative chiral chromatography |
4.3.1 Choice of the stationary phase |
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Sommario/riassunto |
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The development of chiral liquid chromatography, facilitating the straightforward separation of enantiomers, was a significant advance in chromatography, leading to widespread application in analytical chemistry. Application in preparative chromatography has been less rapid, but with the development of single enantiomer pharmaceuticals its use is increasingly common in chemical synthesis at laboratory, pilot plant and even full production scale. Brings non-experts up to speed quickly and comprehensively, facilitating the rapid development of effective separations of enantiomeri |
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2. |
Record Nr. |
UNINA9910131274203321 |
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Autore |
Natsuume Makoto |
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Titolo |
AdS/CFT Duality User Guide / / by Makoto Natsuume |
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Pubbl/distr/stampa |
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Tokyo : , : Springer Japan : , : Imprint : Springer, , 2015 |
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ISBN |
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Edizione |
[1st ed. 2015.] |
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Descrizione fisica |
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1 online resource (XI, 294 p. 75 illus., 11 illus. in color.) |
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Collana |
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Lecture Notes in Physics, , 0075-8450 ; ; 903 |
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Disciplina |
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Soggetti |
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Quantum field theory |
String models |
Nuclear physics |
Heavy ions |
Phase transformations (Statistical physics) |
Condensed matter |
Particles (Nuclear physics) |
Gravitation |
Quantum Field Theories, String Theory |
Nuclear Physics, Heavy Ions, Hadrons |
Quantum Gases and Condensates |
Elementary Particles, Quantum Field Theory |
Classical and Quantum Gravitation, Relativity Theory |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Bibliographic Level Mode of Issuance: Monograph |
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Nota di bibliografia |
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Includes bibliographical references and index. |
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Nota di contenuto |
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Introduction -- General relativity and black holes -- Black holes and thermodynamics -- Strong interaction and gauge theories -- The road to AdS/CFT -- The AdS spacetime -- AdS/CFT - equilibrium -- AdS/CFT - adding probes -- Basics of nonequilibrium physics -- AdS/CFT - non-equilibrium -- Other AdS spacetimes -- Applications to quark-gluon plasma -- Basics of phase transition -- AdS/CFT - phase transition. |
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Sommario/riassunto |
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This book describes applications of the AdS/CFT duality to the "real world." The AdS/CFT duality is an idea that originated from string theory and is a powerful tool for analyzing strongly-coupled gauge theories using classical gravitational theories. In recent years, it has |
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been shown that one prediction of AdS/CFT is indeed close to the experimental result of the real quark–gluon plasma. Since then, the AdS/CFT duality has been applied to various fields of physics; examples are QCD, nuclear physics, condensed-matter physics, and nonequilibrium physics. The aim of this book is to provide background materials such as string theory, black holes, nuclear physics, condensed-matter physics, and nonequilibrium physics as well as key applications of the AdS/CFT duality in a single volume. The emphasis throughout the book is on a pedagogical and intuitive approach focusing on the underlying physical concepts. It also includes step-by-step computations for important results, which are useful for beginners. This book will be a valuable reference work for graduate students and researchers in particle physics, general relativity, nuclear physics, nonequilibrium physics, and condensed-matter physics. . |
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