Development of the cardiac conduction system [[electronic resource]]

• Record Nr.: UNINA9910831050903321
• Pubbl/distr/stampa: Chichester, UK ; ; Hoboken, NJ, : J. Wiley, 2003
• ISBN: 1-280-27213-9; 9786610272136; 0-470-66781-8; 0-470-86803-1; 0-470-86806-6
• Descrizione fisica: 1 online resource (301 p.)
• Collana: Novartis Foundation symposium ; ; 250
• Altri autori (Persone): ChadwickDerek; GoodeJamie
• Disciplina: 612.1/71; 612.17
• Soggetti: Heart conduction system; Heart - Growth
• Lingua di pubblicazione: Inglese
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Note generali: "Symposium on Development of the Cardiac Conduction System, held at the Novartis Foundation, London, May 21-23, 2002"--P. v.; Includes bibliographical references and index.; "Editors, Derek J. Chadwick (organizer) and Jamie Goode"--Contents p.
• Nota di bibliografia: Includes bibliographical references and index.
• Nota di contenuto: DEVELOPMENT OF THE CARDIAC CONDUCTION SYSTEM; Contents; Participants; Chair's introduction; The morphology of the cardiac conduction system; Discussion; Development of the cardiac conduction system: a matter of chamber development; Discussion; Mouse models for cardiac conduction system development; Discussion; Developmental transitions in cardiac conduction; Discussion; Gap junctional connexins in developing mouse cardiac conduction system; Discussion; His-Purkinje lineages and development; Discussion; The role of neural crest and epicardium-derived cells in conduction system formation; DiscussionInduction and patterning of the Purkinje fibre network; Discussion; The oldest, toughest cells in the heart; Discussion; Transcriptional regulation in the mouse atrioventricular conduction system; Discussion; Patterning of the mouse conduction system; Discussion; Clinical pathology of the cardiac conduction system; ; Discussion; Cardiac conduction and arrhythmia: insights from Nkx2.5 mutations in mouse and humans; Discussion; The genetic origin of atrioventricular conduction disturbance in humans; Discussion; Defects in cardiac conduction system lineages and malignant arrhythmias: developmental pathways and diseaseDiscussion; Final general discussion; Index of contributors; Subject index
• Sommario/riassunto: The pacemaking and conduction system (PCS) is vital for generating and synchronizing the heart beat. Dysfunction of this system can be a direct cause of cardiac conduction disturbance, arrhythmias and sudden cardiac death. A wealth of information has been collected over many years on the unique histological, morphological and phenotypic characteristics of specialized cardiac tissues. The cellular and molecular mechanisms that govern development of the PCS are now starting to be understood. This book draws together contributions from an international and interdisciplinary group of experts w