1.

Record Nr.

UNINA9910831014603321

Autore

Mori Keita

Titolo

Metal-Responsive Base Pair Switching of Ligand-type Uracil Nucleobases [[electronic resource] /] / by Keita Mori

Pubbl/distr/stampa

Singapore : , : Springer Nature Singapore : , : Imprint : Springer, , 2024

ISBN

981-9994-00-4

Edizione

[1st ed. 2024.]

Descrizione fisica

1 online resource (137 pages)

Collana

Springer Theses, Recognizing Outstanding Ph.D. Research, , 2190-5061

Disciplina

620.19

547.7

Soggetti

Biomaterials

Nucleic acids

Coordination compounds

Nanotechnology

Self-assembly (Chemistry)

Biocompatible Materials

Nucleic Acids

Layer-by-Layer Nanoparticles

Nucleic Acid

Coordination Chemistry

Self-assembly

Lingua di pubblicazione

Inglese

Formato

Materiale a stampa

Livello bibliografico

Monografia

Nota di contenuto

1. General introduction -- 2. Metal-responsive DNA strand displacement reactions driven by base pair switching of 5-hydroxyuracil nucleobases -- 3. Metal-dependent base pair switching of N,N,-dicarboxymethyl-5-aminouracil nucleosides -- 4. Metal-responsive DNA tweezers driven by base pair switching of 5-hydroxyuracil nucleobases -- 5. Conclusion and perspectives.

Sommario/riassunto

In this thesis, the author proposes "metal-responsive base pair switching" of ligand-modified nucleobases as a novel tool for stimuli-responsive control of DNA assemblies. It is written to demonstrate broad applicability of the base pair switching in dynamic DNA



nanotechnology and inspire researchers to use this technique. Based on specific interactions between ligand-type nucleobases and target metal ions, in this volume, DNA hybridization was dynamically controlled through strand displacement reactions. The base pair switching was further applied to develop metal-dependent DNA molecular machines. This novel strategy for stimuli-responsive regulation of DNA assemblies will greatly expand the scope of dynamic DNA nanotechnology. This volume uniquely features importance of elaborate molecular design based on chemistry for imparting stimuli responsiveness to DNA assemblies.