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Record Nr. |
UNINA9910831001003321 |
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Titolo |
Growth factors as drugs for neurological and sensory disorders [[electronic resource] /] / [editors, Gregory R. Bock (organizer) and Jamie A. Goode] |
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Pubbl/distr/stampa |
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Chichester ; ; New York, : Wiley, 1996 |
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ISBN |
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1-282-12246-0 |
9786612122460 |
0-470-51486-8 |
0-470-51487-6 |
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Descrizione fisica |
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1 online resource (265 p.) |
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Collana |
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Ciba Foundation symposium ; ; 196 |
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Altri autori (Persone) |
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Disciplina |
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Soggetti |
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Nervous system - Degeneration - Chemotherapy |
Nerve growth factor - Therapeutic use |
Neurotropin - Therapeutic use |
Growth factors - Therapeutic use |
Afferent pathways - Diseases - Chemotherapy |
Sensory disorders - Chemotherapy |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Papers presented at a symposium held at the Ciba Foundation, London, 25-27 April 1995. |
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Nota di bibliografia |
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Includes bibliographical references and indexes. |
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Nota di contenuto |
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GROWTH FACTORS AS DRUGS FOR NEUROLOGICAL AND SENSORY DISORDERS; Contents; Participants; Introduction; Motor neuron disease and model systems: aetiologies, mechanisms and therapies; Potential utility of rhlGF-1 in neu romuscular and/or degenerative disease; Therapeutic potential of the n e u rot ro p h i n s and n e u rot ro p h i n-C NT F combinations in peripheral neuropathies and motor neuron diseases; Development of neurotrophic factor therapy for Alzheimer's disease |
Growth factor function in the development and maintenance of midbrain dopaminergic neurons: concepts, facts and prospects for TGF-bSomatic gene therapy for nervous system disease; Neurotrophic |
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factors in the treatment of peripheral neuropathy; General discussion I; Growth factors in the treatment of degenerative retinal disorders; Effects of neurotrophins on the survival and regrowth of injured retinal neurons; Neurotrophic factors as pharmacological agents for the treatment of injured auditory neurons; Growth factors as potential drugs for the sensory epithelia of the ear |
Factors affecting neuronal birth and death in the mammalian olfactory epithelium The problems of delivering neuroactive molecules to the CNS; Closing remarks; Index of contributors; Subject index |
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Sommario/riassunto |
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Degeneration of sensory receptors or of the nerves innervating them leads to a sensory deficit. Various strategies have been tried for promoting regrowth of sensory receptors, particularly in the eye and ear. The latest data from experimental studies in animals are presented in the book including applications of BDNF and CNTF in the eye and epidermal growth factor in the ear. |
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2. |
Record Nr. |
UNINA9910484548903321 |
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Autore |
Zimmerman Dale L. |
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Titolo |
Linear Model Theory : Exercises and Solutions / / by Dale L. Zimmerman |
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Pubbl/distr/stampa |
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Cham : , : Springer International Publishing : , : Imprint : Springer, , 2020 |
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ISBN |
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Edizione |
[1st ed. 2020.] |
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Descrizione fisica |
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1 online resource (VII, 353 p. 4 illus.) |
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Disciplina |
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Soggetti |
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Statistics |
Algebras, Linear |
Statistical Theory and Methods |
Linear Algebra |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Nota di contenuto |
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1 A Brief Introduction -- 2 Selected Matrix Algebra Topics and Results -- 3 Generalized Inverses and Solutions to Sytems of Linear Equations |
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-- 4 Moments of a Random Vector and of Linear and Quadratic Forms in a Random Vector -- 5 Types of Linear Models -- 6 Estimability -- 7 Least Squares Estimation for the Gauss-Markov Model -- 8 Least Squares Geometry and the Overall ANOVA -- 9 Least Squares Estimation and ANOVA for Partitioned Models -- 10 Constrained Least Squares Estimation and ANOVA -- 11 Best Linear Unbiased Estimation for the Aitken Model -- 12 Model Misspecification -- 13 Best Linear Unbiased Prediction -- 14 Distribution Theory -- 15 Inference for Estimable and Predictable Functions -- 16 Inference for Variance-Covariance Parameters -- 17 Empirical BLUE and BLUP. |
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Sommario/riassunto |
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This book contains 296 exercises and solutions covering a wide variety of topics in linear model theory, including generalized inverses, estimability, best linear unbiased estimation and prediction, ANOVA, confidence intervals, simultaneous confidence intervals, hypothesis testing, and variance component estimation. The models covered include the Gauss-Markov and Aitken models, mixed and random effects models, and the general mixed linear model. Given its content, the book will be useful for students and instructors alike. Readers can also consult the companion textbook Linear Model Theory - With Examples and Exercises by the same author for the theory behind the exercises. |
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