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Record Nr. |
UNINA9910830927203321 |
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Autore |
Latgé Jean-Paul |
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Titolo |
Aspergillus fumigatus and Aspergillosis / / Jean-Paul Latgé, William J. Steinbach |
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Pubbl/distr/stampa |
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Washington, D.C. : , : ASM Press, , 2009 |
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ISBN |
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Descrizione fisica |
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1 online resource (xviii, 568 pages) : illustrations (some color) |
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Collana |
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Disciplina |
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Soggetti |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Nota di bibliografia |
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Includes bibliographical references and index. |
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Nota di contenuto |
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Morphology and reproductive mode of Aspergillus fumigatus / Robert A. Samson, János Varga, and Paul S. Dyer -- Molecular methods for species identification and strain typing of Aspergillus fumigatus / S. Arunmozhi Balajee and Corné H.W. Klaassen -- Aspergillus fumigatus specificities as deduced from comparative genomics / Amandine Gastebois [and others] -- Essential genes in Aspergillus fumigatus / Wenqi Hu, Bo Jiang, and Terry Roemer -- Aspects of primary carbon and nitrogen metabolism / Sven Krappmann -- Phospholipases of Aspergillus fumigatus / Geoffrey D. Robson -- Aspergillus fumigatus secreted proteases / Michel Monod, Olivier Jousson, and Utz Reichard -- Cations (Zn, Fe) / José Antonio Calera and Hubertus Haas -- Conidial germination in Aspergillus fumigatus / Nir Osherov -- Growth polarity / Michelle Momany and Yainitza Hernández-Rodriguez -- Biofilm formation in Aspergillus fumigatus / Anne Beauvais and Frank-Michael Müller -- Signal transduction / Gregory S. May and Taylor Schoberle -- Cell wall of Aspergillus fumigatus: a dynamic structure / Isabelle Mouyna and Thierry Fontaine -- Genetic regulation of Aspergillus secondary metabolites and their role in fungal pathogenesis / Robert A. Cramer, Jr, E. Keats Schwab, and Nancy P. Keller -- Aspergillus fumigatus: survival and death under stress / David S. Askew and Judith C. Rhodes -- Reactive Oxygen intermediates, pH, and Calcium / Elaine Bignell -- Innate defense against Aspergillus: the phagocyte / Michel Chignard -- Interactions of Aspergillus with the mucosa / William W. Hope and Scott G. Filler -- Dendritic cells in |
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Aspergillus infection and allergy / Luigina Romani -- CD4+ T-Cell responses to Aspergillus fumigatus / Amariliz Rivera and Eric G. Pamer -- Innate recognition of Aspergillus fumigatus by the mammalian immune system / Lisa M. Graham and Gordon D. Brown -- Invasive pulmonary aspergillosis / Aimee K. Zaas and Barbara D. Alexander -- Aspergillus sinusitis and cerebral aspergillosis / Stefan Schwartz and Markus Ruhnke -- Chronic aspergillosis / David W. Denning -- Allergic bronchopulmonary aspergillosis / Richard B. Moss -- Histology and radiology / Reginald Greene, Kazutoshi Shibuya, and Tsunihiro Ando -- Galactomannan and anti-aspergillus antibody detection for the diagnosis of invasive aspergillosis / Paul E. Verweij -- Aspergillus PCR / P. Lewis White and Rosemary A. Barnes -- Polyenes in the treatment of aspergillosis / Andreas H. Groll and Thomas J. Walsh -- Azoles in the treatment of aspergillosis / Raoul Herbrecht and Yasmine Nivoix -- Echinocandins in the treatment of aspergillosis / Johan Maertens and Vincent Maertens -- Antifungal drug interactions / Russell E. Lewis -- Antifungal mechanisms of action and resistance / David S. Perlin and Emilia Mellado -- Immunotherapy / Brahm H. Segal and Luigina R. Romani -- Prophylaxis against invasive aspergillosis / Jo-Anne H. Young -- Therapy of invasive aspergillosis: current consensus and controversies / Dimitrios P. Kontoyiannis and Kieren A. Marr -- Invasive aspergillosis in solid organ transplant recipients / Hsin-Yun Sun [and others] -- Invasive aspergillosis in malignancy and stem cell transplant recipients / Elio Castagnola and Claudio Viscoli -- Invasive aspergillosis in pediatric patients / Emmanuel Roilides and Paraskevi Panagopoulou -- A perspective view of Aspergillus fumigatus research for the next ten years / Jean-Paul Largé and William J. Steinbach. |
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Sommario/riassunto |
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Modern medical technologies are repairing the human body in ways never imagined only a few years ago, but they are leaving an increasing population of patients who are newly susceptible to opportunistic pathogens. Invasive and chronic fungal infections have become a formidable clinical opponent, and foremost among them is Aspergillus fumigatus. Aspergillus fumigatus and Aspergillosis assembles chapters from a large and international contingent of experts in the field to explore every major aspect of A. fumigatus and how it kills so many patients. This volume offers the latest insights into the fundamental biology and pathogenesis of A. fumigatus and how it establishes disease, as well as the newest strategies for characterizing, diagnosing, and treating its spectrum of clinical infection. This valuable book is an instrumental resource for both scientists and clinicians tackling the current problems with Aspergillosis. It presents chapters on the species itself, including morphology and unique and specific genes, the importance of polarized growth, as well as the organism's response to environmental stress by moving from a saprophyte to a pathogen. The interface with the host immune system paramount to disease phenotype is detailed, as are the many faces of disease created by A. fumigatus. Newer diagnostic and treatment strategies are covered, including the optimal timing of antifungal therapy and the strategic choice of which agent to use. |
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