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1. |
Record Nr. |
UNINA9910830901403321 |
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Titolo |
Handbook of ATPases [[electronic resource] ] : biochemistry, cell biology, pathophysiology / / edited by Masamitsu Futai, Yoh Wada, and Jack H. Kaplan |
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Pubbl/distr/stampa |
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Weinheim, : Wiley-VCH, c2004 |
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ISBN |
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1-280-52094-9 |
9786610520947 |
3-527-60612-2 |
3-527-60628-9 |
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Descrizione fisica |
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1 online resource (495 p.) |
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Altri autori (Persone) |
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Disciplina |
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Soggetti |
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Adenosine triphosphatase |
Adenosine triphosphatase - Pathophysiology |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references and index. |
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Nota di contenuto |
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Handbook of ATPases; Contents; Preface; List of Contributors; Part I P-type ATPases; 1 Yeast Plasma-membrane H(+)-ATPase: Model System for Studies of Structure, Function, Biogenesis, and Regulation; 1.1 Introduction; 1.2 Structure; 1.2.1 Ca(2+)-ATPase as a Model; 1.2.2 Applicability of the Ca(2+)-ATPase Structure to Other P(2)-ATPases, Including the Pma1 H(+)-ATPase; 1.2.3 H(+)-ATPase Oligomers; 1.2.4 Associated Proteolipids; 1.3 Reaction Mechanism; 1.3.1 Overview of the Reaction Cycle; 1.3.2 ATP Binding and Phosphorylation; 1.3.3 E1-E2 Conformational Change; 1.3.4 H(+) Pumping |
1.4 Biogenesis1.4.1 Pma1 Mutants with Defects in Folding and Biogenesis; 1.4.2 Use of Pma1 Mutants to Screen for Other Genes that Play a Role in Biogenesis and Quality Control; 1.4.3 Role of Lipid Rafts; 1.5 Regulation; 1.6 Emerging Knowledge of Other Yeast P-type ATPases; Acknowledgments; References; 2 Regulation of the Sarco(endo)plasmic Reticulum Ca(2+)-ATPase by Phospholamban and |
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Sarcolipin; 2.1 Introduction; 2.1.1 Background to Ca(2+) Signaling; 2.1.2 β-Adrenergic Signaling in the Heart; 2.2 Phospholamban-SERCA Interactions; 2.2.1 SERCA Structure and Function |
2.2.2 PLN Structure and Function2.2.3 Approaches to the Study of PLN-SERCA Interactions; 2.2.4 SERCA Residues Essential for Cytoplasmic Interaction with PLN; 2.2.5 PLN Residues Essential for Cytoplasmic Interaction with SERCA; 2.2.6 PLN Residues Essential for Transmembrane Interactions with SERCA; 2.2.7 SERCA Residues Essential for Transmembrane Interactions with PLN; 2.2.8 Structural Modeling of the PLN-SERCA Inhibitory Interaction; 2.3 Physiological Role of PLN in Basal Cardiac Function; 2.3.1 Alterations in PLN Levels and Function by Transcription and Phosphorylation |
2.3.2 Targeting of PLN2.3.3 Role of PLN in Smooth and Skeletal Muscles; 2.3.4 Overexpression of PLN; 2.3.5 Physiological Role of PLN in β-Adrenergic Stimulation; 2.3.6 Superinhibitory PLN Mutants; 2.4 Phospholamban in Heart Failure; 2.4.1 Introduction; 2.4.2 Potential Therapies; 2.5 Human PLN Mutations as a Cause of Cardiomyopathy; 2.5.1 PLN R9C Mutant; 2.5.2 PLN L39stop Mutant; 2.6 Sarcolipin; 2.6.1 Introduction; 2.7 Physiological Role of SLN; 2.7.1 SLN Expression; 2.7.2 Overexpression of SLN; 2.7.2.1 Response of the SLN Gene to Chronic Stimulation |
2.7.3 Inhibition of SERCA Function by SLN Plus PLN2.7.4 Modeling of the SLN-SERCA and SLN-PLN-SERCA Interactions; Acknowledgments; References; 3 Catalytic and Transport Mechanism of the Sarco-(Endo)Plasmic Reticulum Ca(2+)-ATPase (SERCA); Summary; 3.1 Introduction; 3.2 Experimental Systems; 3.3 Functional Characterization; 3.4 Structural Characterization; 3.4.1 Extramembranous Region and the Catalytic Domains of E1·2Ca(2+); 3.4.2 Transmembrane region of E1·2Ca(2+); 3.4.3 Enzyme Structure in the Absence of Ca(2+) (E2·TG); 3.4.4 Thapsigargin-binding Domain; 3.4.5 Interaction with Phospholamban |
3.5 Binding of Ligands, Catalytic Events and Conformational Changes |
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Sommario/riassunto |
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As the first comprehensive overview of this important class of enzymes, this two-volume handbook summarizes recent knowledge about the molecular mechanism of ATPases, relating this information to the physiology and pathopyhsiology of ion transport, mitochondrial function, vesicle transport and lysosomal acidification. All important P-type, F-type and V-type ATPases are treated systematically, complemented by a special section on the cell biology and physiology of acidic compartments, and backed by an extensive bibliography and index. This premier reference source for physiologists, molecular |
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2. |
Record Nr. |
UNINA9910830828203321 |
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Titolo |
Urban regeneration in Europe [[electronic resource] /] / edited by Chris Couch, Charles Fraser, and Susan Percy |
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Pubbl/distr/stampa |
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Oxford ; ; Malden, MA, : Blackwell Science, 2003 |
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ISBN |
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1-281-31852-3 |
9786611318529 |
0-470-70920-0 |
0-470-69060-7 |
0-470-68033-4 |
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Descrizione fisica |
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1 online resource (256 p.) |
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Collana |
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Altri autori (Persone) |
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CouchChris |
FraserCharles |
PercySusan <1965-> |
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Disciplina |
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307.3/416/094 |
307.3416094 |
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Soggetti |
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Urban renewal - Europe, Western |
Deindustrialization - Europe, Western |
Land use, Urban - Europe, Western |
Urban policy - Europe, Western |
Urban ecology (Sociology) - Europe, Western |
Europe, Western Social conditions |
Europe, Western Economic conditions |
Europe, Western Environmental conditions |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references (p. [217]-226) and index. |
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Nota di contenuto |
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Urban Regeneration in Europe; Contents; Contributors; Preface; Acknowledgements; Acronyms; 1 Introduction: the European Context and Theoretical Framework; The contemporary European context; Issues in international comparative urban research; Research methodology; The choice of localities; The structure of the case studies; 2 Change in the European Industrial City; The origins of the industrial city; The decline of the industrial city; The case for intervention; National policy responses; The impact of the European |
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Union; New challenges; The response to the challenge |
3 Urban Regeneration in LiverpoolThe city centre and docklands; Vauxhall and North Liverpool; Conclusions; 4 Dundee: a City Discovering Inclusion and Regeneration; Introduction; Historic context; Decline and change; Revival; Culture, partnership and regionalism; Emerging agendas; Conclusion; 5 Urban Regeneration in Belfast; Historical background; Recent population changes; Political context; Belfast City Council; Planning; Housing; Urban regeneration; Economic growth; Conclusion; 6 Lille: from Textile Giant to Tertiary Turbine; Decline and the seeds of renewal; A changing image in the Nord |
Economic restructuringThe Channel Tunnel; Administrative reform; The spatial planning context; The development results; An international profile; Case studies; The evolution of French regeneration; Summary; 7 Rotterdam: Structural Change and the Port; Renewing older inner-city neighbourhoods; Rebuilding and maintaining the city centre; Kop van Zuid; Conclusions; 8 Belgium: the Case of Wallonie; Historical background; A new beginning and a new programme; The process in action; Summary; 9 Milan: the Bovisa District; The historic context; Decline and change; Revival; Emerging agendas; Notes |
10 The Ruhr: from Dereliction to RecoveryBackground; Regeneration and development in the Ruhr region; Emscher Park International Building Exhibition (IBA); Conclusion; 11 Economic and Physical Influences on Urban Regeneration in Europe; Geographical location; The strength of the regional economy; The use of land and buildings; Conclusions; 12 The Institutional and Financial Conditions of Urban Regeneration in Europe; Administrative structures; Political processes; Financial structures; Summary; 13 New Agendas; Globalisation and place marketing; New industries and links to education |
Social exclusionNew alliances and partnerships; Promoting sustainability; Conclusions; 14 Review; Bibliography; Index |
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Sommario/riassunto |
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This book provides a comparative account of the process of urban regeneration and examines the factors influencing these processes, as well as the consequences of their implementation. Through a mixture of theoretical discussion and a series of case studies a thorough examination is made of the extent to which these different European old industrial conurbations are facing similar problems. |
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3. |
Record Nr. |
UNINA9910137152103321 |
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Titolo |
Bulletin on the rheumatic diseases / / Arthritis Foundation |
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Pubbl/distr/stampa |
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Atlanta, Ga., : The Foundation |
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Descrizione fisica |
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Disciplina |
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Soggetti |
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Rheumatism |
Arthritis |
Rheumatic Diseases |
Rhumatisme |
Arthrite |
Periodical |
Periodicals. |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Periodico |
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Note generali |
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