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Record Nr. |
UNINA9910830864303321 |
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Titolo |
Protein degradation . Vol. 4 The ubiquitin-proteasome system and disease / / edited by R. John Mayer, Aaron Ciechanover, Martin Rechsteiner |
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Pubbl/distr/stampa |
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Weinheim, Germany : , : WILEY-VCH Verlag GmbH & Co. KGaA, , 2008 |
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©2008 |
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ISBN |
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1-283-14037-3 |
9786613140371 |
3-527-62023-0 |
3-527-62030-3 |
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Descrizione fisica |
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1 online resource (260 p.) |
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Collana |
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Protein Degradation ; ; v.8 |
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Disciplina |
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Soggetti |
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Proteins - Metabolism |
Ubiquitin |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references at the end of each chapters and index. |
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Nota di contenuto |
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Protein Degradation; Contents; Preface; List of Contributors; 1 Ubiquitin Signaling and Cancer Pathogenesis; 1.1 Introduction; 1.1.1 Ubiquitin Signaling Networks; 1.1.2 Ubiquitin-like Proteins; 1.2 Ubiquitin in Cancer Pathogenesis; 1.2.1 Ubiquitin in Cell Cycle Control; 1.2.2 Ubiquitin in the NF-κB Pathway; 1.2.3 Ubiquitin as a Signal in DNA Repair; 1.2.3.1 p53 Pathway; 1.2.3.2 BRCA1 and FANCD2; 1.2.3.3 PCNA and TLS Polymerases; 1.2.4 Ubiquitin Networks in Angiogenesis; 1.2.5 Ubiquitin Networks in Receptor Endocytosis; 1.3 Targeting Ubiquitin Networks in Cancers |
1.3.1 Targeting Interactions between E3s and their Substrates1.3.2 Targeting the Proteasome; 1.3.3 Other Approaches; 1.4 Conclusions and Future Perspectives; 2 Regulation of the p53 Tumor-suppressor Protein by Ubiquitin and Ubiquitin-like Molecules; 2.1 Functional Domains of p53; 2.2 The Family of Ubiquitin-like Molecules; 2.3 E3 Ligases for p53; 2.4 Modification of p53 with Ubiquitin; 2.5 |
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