The power of functional resins in organic synthesis [[electronic resource] /] / edited by Judit Tulla-Puche and Fernando Albericio

• Record Nr.: UNINA9910830805603321
• Pubbl/distr/stampa: Weinheim, : Wiley-VCH, c2008
• ISBN: 1-282-02535-X; 9786612025358; 3-527-62617-4; 3-527-62618-2
• Descrizione fisica: 1 online resource (685 p.)
• Classificazione: 540; VK 5500
• Altri autori (Persone): AlbericioFernando; Tulla-PucheJudit
• Disciplina: 547.2
• Soggetti: Gums and resins, Synthetic; Organic compounds - Synthesis
• Lingua di pubblicazione: Inglese
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Note generali: Description based upon print version of record.
• Nota di bibliografia: Includes bibliographical references and index.
• Nota di contenuto: The Power of Functional Resins in Organic Synthesis; Contents; Preface; Part One: Introduction; 1: The (Classic Concept of) Solid Support; 1.1 Introduction; 1.2 Linkers/Handles; 1.3 Solid Supports; 1.3.1 Gel-Type Support; 1.3.1.1 Polystyrene (PS) Resins; 1.3.1.2 Poly(Ethylene Glycol)-Polystyrene (PEG-PS) Resins; 1.3.1.3 Hydrophilic PEG-Based Resins; 1.3.2 Modified Surface Type Supports; 1.3.2.1 Cellulose Membranes; 1.3.2.2 Polyolefinic Membranes; 1.3.2.3 Pellicular Solid Supports; Acknowledgments; References; 2: Molecularly Imprinted Polymers; 2.1 Introduction; 2.2 The Concept of Molecular Imprinting2.2.1 Non-covalent Molecular Imprinting; 2.2.2 Covalent Molecular Imprinting; 2.2.3 Semi-covalent Molecular Imprinting; 2.2.4 Metal Ion Mediated Molecular Imprinting; 2.3 Formats of Molecularly Imprinted Polymers; 2.3.1 Irregularly Shaped Particles; 2.3.2 Beads; 2.3.2.1 Homogeneous Polymerization; 2.3.2.2 Heterogeneous Polymerization; 2.3.2.3 Two-Step Swelling Polymerization; 2.3.2.4 Core-Shell Polymerization; 2.3.2.5 Silica Composite Beads; 2.3.3 Films and Membranes; 2.4 Design of MIPs; ; 2.4.1 Functional Monomers; 2.4.2 Cross-linking Monomers; 2.4.3 The Porogen2.4.4 Initiation of Polymerization; 2.4.5 Optimization of Imprinting Conditions; 2.5 Characterization of Molecularly Imprinted Polymers; 2.5.1 Characterization of Binding Properties of MIPs; 2.5.2 Characterization of Chemical and Physical Properties of MIPs; 2.6 Applications of Molecularly Imprinted Polymers; 2.6.1 Liquid Chromatography; 2.6.2 Solid-Phase Extraction; 2.6.3 Solid-Phase Binding Assay; 2.6.4 Sensors; 2.6.4.1 Optical Sensors; 2.6.4.2 Mass Sensitive Sensors; 2.6.4.3 Electrochemical Sensors; 2.6.5 Synthetic Enzymes; 2.7 Conclusions; References; 3: Nanoparticles Functionalized with Bioactive Molecules: Biomedical Applications3.1 Introduction; 3.2 MNPs; 3.2.1 Gold Nanoparticles; 3.2.1.1 Synthesis and Properties; 3.2.1.2 Functionalization of GNPs with Bioactive Compounds and Biomedical Applications of Functionalized GNPs; 3.2.2 Nanoshells and Metal Heterodimers; 3.2.3 Iron Oxide NPs; 3.2.3.1 Synthesis and Properties; 3.2.3.2 Functionalization of IONPs; 3.2.4 Silver NPs; 3.2.5 Quantum Dots; 3.2.6 Nanowires; 3.3 CNTs; 3.4 Organic Nanoparticles (ONPs); 3.4.1 Synthesis and Properties of ONPs; 3.4.2 Functionalization Strategies; 3.4.3 ONPs Types and Applications3.4.3.1 Fluorescent ONPs; 3.4.3.2 Cancer-Aimed ONPs; 3.4.3.3 Delivery of ONPs through the Blood-Brain Barrier (BBB); 3.4.3.4 Nucleic Acids/Gene Delivery; 3.4.3.5 Other Biomedical Uses of ONPs; 3.5 Conclusions; Acknowledgments; List of Abbreviations; References; Part Two: Solid-Supported Reagents and Scavengers; 4: Oxidizing and Reducing Agents; 4.1 Introduction; 4.2 Considerations Concerning the Nature of the Solid Support Used for Polymer-Supported Redox Reagents; 4.3 Oxidizing Resins; 4.3.1 Novel Oxidative Resins; 4.3.1.1 Solid-Supported Hypervalent Iodine Reagents
• Sommario/riassunto: While many books cover solid phase synthesis and combinatorial synthesis, this one is unique in its exclusive coverage of the other aspects of solid-phase synthesis. As such, it contains everything you need to know -- from supported reagents, to scavengers, resins, and the synthesis of biomolecules and natural products.An invaluable companion for all chemists and biochemists working in university research and industry.