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Record Nr. |
UNINA9910830794403321 |
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Titolo |
Fragment-based drug discovery [[electronic resource] ] : a practical approach / / editors, Edward R. Zartler, Michael J. Shapiro |
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Pubbl/distr/stampa |
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Chichester, U.K., : John Wiley & Sons, 2008 |
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ISBN |
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1-282-34275-4 |
9786612342752 |
0-470-72155-3 |
0-470-72156-1 |
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Descrizione fisica |
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1 online resource (297 p.) |
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Altri autori (Persone) |
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ZartlerEdward |
ShapiroMichael (Michael J.) |
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Disciplina |
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Soggetti |
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Drug development |
Drugs - Design |
Ligands (Biochemistry) |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references and index. |
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Nota di contenuto |
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Fragment-Based Drug Discovery; Contents; List of Contributors; 1 Introduction to Fragment-based Drug Discovery; 2 Designing a Fragment Process to Fit Your Needs; 3 Assembling a Fragment Library; 4 Practical Aspects of Using NMR in Fragment-based Screening; 5 Application of Protein-Ligand NOE Matching to the Rapid Evaluation of Fragment Binding Poses; 6 Target-immobilized NMR Screening: Validation and Extension to Membrane Proteins; 7 In Situ Fragment-based Medicinal Chemistry: Screening by Mass Spectrometry; 8 Computational Approaches to Fragment and Substructure Discovery and Evaluation |
9 Virtual Fragment Scanning: Current Trends, Applications and Web-based Tools10 Capture Methods for Fragment-based Discovery; 11 Identification of High-affinity -Secretase Inhibitors Using Fragment-based Lead Generation; Index |
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Sommario/riassunto |
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Fragment-based drug discovery (FBDD) is a new paradigm in drug discovery that utilizes very small molecules - fragments of larger |
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