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1. |
Record Nr. |
UNINA990008232010403321 |
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Titolo |
Camera dei Deputati : indagini conoscitive e documentazioni legislative. Commissione I (affari costituzionali, della Presidenza del Consiglio e interni) N.11 |
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Pubbl/distr/stampa |
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Roma : Tip. Colombo, 1991 |
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Descrizione fisica |
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Locazione |
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Collocazione |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Sul frontespizio compare: Atti parlamentari X legislatura |
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2. |
Record Nr. |
UNINA9910830726003321 |
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Titolo |
Transcription factors [[electronic resource] ] : normal and malignant development of blood cells / / edited by Katya Ravid, Jonathan Licht |
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Pubbl/distr/stampa |
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New York, : Wiley-Liss, c2001 |
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ISBN |
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1-280-36661-3 |
9786610366613 |
0-470-34865-8 |
0-471-46106-7 |
0-471-22388-3 |
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Descrizione fisica |
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1 online resource (642 p.) |
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Altri autori (Persone) |
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RavidKatya |
LichtJonathan D |
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Disciplina |
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Soggetti |
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Hematopoiesis |
Genetic regulation |
Leukemia - Genetic aspects |
Transcription factors |
Genetic transcription |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Includes bibliographical references and index. |
Includes index. |
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Nota di contenuto |
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TRANSCRIPTION FACTORS; CONTENTS; Introduction; Contributors; I TRANSCRIPTION FACTORS AND THE MEGAKARYOCYTIC AND ERYTHROID LINEAGES; 1 The Role of GATA-1 and FOG in Erythroid and Megakaryocytic Differentiation; 2 Regulation of Megakaryocyte and Erythroid Differentiation by NF-E2; 3 Transcription Factors Involved in Lineage-Specific Gene Expression During Megakaryopoiesis; 4 Role of TAL1/SCL Transcription Factor in Normal and Leukemic Hematopoiesis; 5 EKLF and the Development of the Erythroid Lineage; II TRANSCRIPTION FACTORS AND THE MYELOID LINEAGE |
6 RUNX1(AML1) and CBFB: Genes Required for the Development of All Definitive Hematopoietic Lineages7 PU.1 and the Development of the Myeloid Lineage; 8 CCAAT/Enhancer-Binding Proteins in Myeloid Cells; 9 Homeobox Gene Networks and the Regulation of Hematopoiesis; 10 The Role of Retinoic Acid Receptors in Myeloid Differentiation; 11 Transcriptional Targets of the Vitamin D(3) Receptor During Myeloid Cell Differentiation; III TRANSCRIPTION FACTORS AND THE LYMPHOID LINEAGE; 12 The Role of Ikaros Family Genes in Lymphopcyte Differentiation and Proliferation |
13 The Role of PU.1 in B-Lymphocyte Development and Function14 The Role of Pax5 (BSAP) in Early and Late B-Cell Development; 15 Janus Kinases and STAT Family Transcription Factors: Their Role in the Function and Development of Lymphoid Cells; 16 E2A and the Development of B and T Lymphocytes; 17 The Role of BCL-6 in Normal Lymphoid System and non-Hodgkin's Lymphomas; 18 The Role of Octamer Factors and Their Coactivators in the Lymphoid System; 19 The Role of Early B-Cell Factor in B-Lymphocyte Development; IV. TRANSCRIPTION FACTORS INVOLVED IN LEUKEMIAS DUE TO CHROMOSOMAL TRANSLOCATION |
20 The Role of RARa and Its Fusion Partners in Acute Promyelocytic Leukemia21 The Leukemogenic Function of the inv(16) Fusion Gene CBFB-MYH11; 22 EVI1 Rearrangements in Malignant Hematopoiesis; 23 t(8; 21) AML and the AML1/ETO Fusion Gene: From Clinical Syndrome to Paradigm for the Molecular Basis of Acute Leukemia; 24 TEL/ETV6 Gene Rearrangements in Human Leukemias; 25 MLL in Normal and Malignant Hematopoiesis; 26 Coactivators and Leukemia: The Acetylation Connection with Translocations Involving CBP, p300, TIF2, MOZ, and MLL; 27 The LMO2 Master Gene |
Its Role as a Transcription Regulator Determining Cell Fate in Leukemogenesis and in Hematopoiesis28 The Acetyltransferases CBP and p300: Molecular Integrators of Hematopoietic Transcription Involved in Chromosomal Translocations; V. ONCOGENESIS AND HEMATOPOIESIS; 29 The Roles of the c-myc and c-myb Oncogenes in Hematopoiesis and Leukemogenesis; 30 NF-kB in Cell Life and Death; VI. SUMMARY OF TRANSCRIPTION FACTORS IMPLICATED IN HEMATOPOIESIS: IN VIVO STUDIES; 31 Transcription Factors Implicated in Hematopoiesis: In Vivo Studies |
32 Chromosomal Translocations Associated with Disruption of Transcriptional Regulators in Leukemia and Lymphoma |
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Sommario/riassunto |
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The role of transcription factors in activating specific genes in blood cells is an important facet of hematopoiesis. Equally important, |
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however, is the pursuit of genes rearranged and aberrantly activated in leukemias (blood malignancies). Transcription Factors: Normal and Malignant Development of Blood Cells focuses on those major transcription factors involved in activation of lineage-specific gene expression during normal versus malignant development of specific blood lineages, as revealed from gene promoter studies, knockout of transcription factors in mice models, and the |
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