Intracellular niches of microbes [[electronic resource] ] : a pathogens guide through the host cell / / edited by Ulrich E. Schaible & Albert Haas

• Record Nr.: UNINA9910830678003321
• Pubbl/distr/stampa: Weinheim, : Wiley-VCH, 2009
• ISBN: 1-282-30663-4; 9786612306631; 3-527-62917-3; 3-527-62918-1
• Descrizione fisica: 1 online resource (738 p.)
• Altri autori (Persone): SchaibleUlrich E; HaasAlbert, Prof
• Disciplina: 577.857
• Soggetti: Host-parasite relationships; Intracellular pathogens
• Lingua di pubblicazione: Inglese
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Note generali: Description based upon print version of record.
• Nota di bibliografia: Includes bibliographical references and index.
• Nota di contenuto: Intracellular Niches of Microbes: A Pathogens Guide Through the Host Cell; Foreword; Contents; List of Contributors; Part I: General Aspects; 1 Introduction: The Evolution of Intracellular Life Forms and their Niches; 1.1 A Short History of Theories and Discoveries; 1.2 A Look Through the Microscope of Evolution; 1.3 Continuous Exchange of Information; 1.4 Evolution of Intracellular Parasitism; 1.5 Intracellular Symbionts: Tamed or Acclimatized Parasites?; 1.6 An Ecological View of Intracellular Life; 1.7 The Immunologist's View; 1.8 The Public Health View; 1.9 The Book; References; 2 Limited Genomes and Gene Transfer in the Evolution of Intracellular Parasitism and Symbiosis2.1 Introduction to Gene Transfer and Evolution; 2.2 Gene Transfer in Intracellular Bacterial Parasites; 2.3 Gene Transfer in Intracellular Symbionts; 2.4 Gene Transfer in Intracellular Parasites and Fungi; 2.5 Summary and Outlook; References; 3 Phagocytosis: Early Events in Particle Recognition and Uptake; 3.1 Phagocytosis: An Overview; 3.2 Recognition of Target Particles; 3.3 Signaling Events Upon Ligand Recognition; 3.4 Membrane ; Dynamics During Phagocytosis; 3.5 Phagosome Maturation; 3.6 Inflammatory Signals Linked to Phagocytosis3.7 Concluding Remarks; References; 4 Cellular Model Systems Used to Study Phagosome Biogenesis; 4.1 From Grazing to Host Defense; 4.2 Dictyostelium, a Professional Phagocyte at the Border of Multicellularity; 4.3 Dictyostelium, a Surrogate Host for Legionella, Mycobacterium and Other Pathogens; 4.4 Legionella-directed Phagosome Biogenesis; 4.5 The Whole Animal Model Drosophila melanogaster; 4.6 Infection of Drosophila Phagocytes; 4.7 Conclusions; References; 5 Methods Used to Study Phagosome Biogenesis; 5.1 Describing the World Within - Whole-Cell Assays for Phagosome Contents5.2 Biochemical Analysis and Assays with Purified Phagosomes; 5.3 Use of Fluorescence-Activated Cell Sorting (FACS) in Phagosome Research; 5.4 Knockdown, Knockout and Phagosome Research; 5.5 Transcriptomics as a Phagosome Environmental Sensor; References; 6 In Vitro Fusion Assays with Phagosomes; 6.1 Introduction; 6.2 A Variety of Assays; 6.3 Studying Normal Maturation . . .; 6.4 . . . and the Pathogenic Case; References; 7 Phagosome Proteomes Unite! A Virtual Model of Maturation as a Tool to Study Pathogen-Induced Changes7.1 Background; 7.2 A Methods Guide to Phagosome Proteomics; 7.3 Particle-Induced Impact on Phagosome Isolation; 7.4 Comparative Proteomics of Microbe-Containing Vacuoles; 7.5 Conclusions; References; 8 Phagosome-Cytoskeleton Interactions; 8.1 Introduction; 8.2 The Actin Cytoskeleton. General Background; 8.3 The Microtubule Cytoskeleton - General Background; 8.4 Concluding Remarks; References; 9 Intracellular Microbe Whole-Genome Expression Profiling: Methodological Considerations and Biological Inferences
• Sommario/riassunto: The book describes the different and exciting pathways which have been developed by pathogenic microbes to manage living inside host cells. It covers intracellular life styles of all relevant pathogenic but also symbiotic microorganisms with respect to the cell biology of the host-microbe interactions and the microbial adaptations for intracellular survival. It features intracellular trafficking pathways and characteristics of intracellular niches of individual microbes. The book also asks questions on the benefits for the microbe with regard to physiological needs and nutritional aspects such