| |
|
|
|
|
|
|
|
|
1. |
Record Nr. |
UNINA9910830632603321 |
|
|
Titolo |
Antitargets [[electronic resource] ] : prediction and prevention of drug side effects / / edited by Roy J. Vaz and Thomas Klabunde |
|
|
|
|
|
|
|
Pubbl/distr/stampa |
|
|
Weinheim, : Wiley-VCH |
|
[Chichester, : John Wiley, distributor], c2008 |
|
|
|
|
|
|
|
|
|
ISBN |
|
1-282-78430-7 |
9786612784309 |
3-527-62147-4 |
3-527-62146-6 |
|
|
|
|
|
|
|
|
Descrizione fisica |
|
1 online resource (506 p.) |
|
|
|
|
|
|
Collana |
|
Methods and principles in medicinal chemistry ; ; v. 38 |
|
|
|
|
|
|
Altri autori (Persone) |
|
|
|
|
|
|
|
|
Disciplina |
|
|
|
|
|
|
Soggetti |
|
Drugs - Side effects |
Drugs - Side effects - Prevention |
Drug interactions |
Drug development |
Drugs - Structure-activity relationships |
|
|
|
|
|
|
|
|
Lingua di pubblicazione |
|
|
|
|
|
|
Formato |
Materiale a stampa |
|
|
|
|
|
Livello bibliografico |
Monografia |
|
|
|
|
|
Note generali |
|
Description based upon print version of record. |
|
|
|
|
|
|
Nota di bibliografia |
|
Includes bibliographical references and index. |
|
|
|
|
|
|
Nota di contenuto |
|
Antitargets; Contents; List of Contributors; Preface; I General Aspects; 1 Why Drugs Fail - A Study on Side Effects in New Chemical Entities; 1.1 Introduction; 1.2 Drugs Withdrawn from the Market between 1992 and 2006 Listed Alphabetically; 1.2.1 Amineptine; 1.2.2 Aminophenazone (Aminopyrine); 1.2.3 Astemizole; 1.2.4 Bromfenac Sodium; 1.2.5 Cerivastatin; 1.2.6 Chlormezanone; 1.2.7 Fenfluramine and Dexfenfluramine; 1.2.8 Flosequinan; 1.2.9 Glafenine; 1.2.10 Grepafloxacin; 1.2.11 Levacetylmethadol; 1.2.12 Mibefradil; 1.2.13 Rapacuronium Bromide; 1.2.14 Rofecoxib; 1.2.15 Temafloxacin |
1.2.16 Troglitazone1.2.17 Ximelagatran; 1.3 Borderline Cases; 1.4 Investigational Drugs That Failed in Clinical Phases from 1992 to 2002; 1.4.1 A Case Study: Fialuridine; 1.4.2 A Recent Case Study: Torcetrapib; 1.4.3 General Reasons for Project Failing in Clinical Phases I-III; 1.5 Strategies for Avoiding Failure; 1.6 An Unusual Case: The Revival of |
|
|
|
|
|
|
|
|
|
|
|
Thalidomide; References; 2 Use of Broad Biological Profiling as a Relevant Descriptor to Describe and Differentiate Compounds: Structure-In Vitro (Pharmacology-ADME)-In Vivo (Safety) Relationships; 2.1 Introduction |
2.1.1 Biological Profiling/Fingerprints and Drug Discovery Applications2.1.2 Polypharmacology of Drugs; 2.2 The BioPrint(®) Approach; 2.2.1 BioPrint(®) - General; 2.2.2 BioPrint(®) Assay Selection and Profile Description; 2.2.3 Compounds in BioPrint(®); 2.2.4 BioPrint(®) In Vivo Data sets; 2.2.4.1 Compound Details; 2.2.4.2 ADR Data; 2.2.4.3 Pharmacokinetics; 2.2.4.4 Toxicity Data; 2.3 Structure-In Vitro Relationships; 2.3.1 Similarity, Chemotypes - What Is a Biologically Relevant Descriptor?; 2.3.2 Using Biological Fingerprints as a Meaningful Descriptor for Drug Leads and Candidates |
2.3.2.1 Differentiation of Leads2.3.2.2 Analysis of Attrited Compounds; 2.3.3 Structural versus Experimental Differentiation - Dependence on Structure-Derived Descriptor Used; 2.3.4 Predictive Models from Pharmacological Data; 2.3.5 Predictive Models from ADME Data - BioPrint(®) Learnings; 2.4 Chemogenomic Analysis - Target-Target Relationships; 2.5 In Vitro-In Vivo Relationships - Placing Drug Candidates in the Context of BioPrint(®); 2.5.1 Analyzing Potential ADR Liabilities Based on Individual Hits; 2.5.2 Analyzing Potential ADR Liabilities Based on Profile Similarity |
2.6 A Perspective for the FutureReferences; II Antitargets: Ion Channels and GPCRs; 3 Pharmacological and Regulatory Aspects of QT Prolongation; 3.1 Introduction; 3.2 hERG: Target Versus Antitarget; 3.3 Pharmacology of QT Prolongation; 3.3.1 Multiple Mechanisms Leading to QT Prolongation; 3.3.2 hERG as the Key Mechanism for the Drug-Induced Long QT Syndrome; 3.3.3 Pharmacogenetic Aspects; 3.4 Significance of Drug-Induced QT Prolongation; 3.4.1 Prolonged QT/QTc and Occurrence of TdP; 3.4.2 Dose-Response Relationship for QT Prolongation; 3.5 Regulatory Aspects of QT Prolongation |
3.5.1 Regulatory Guidance Documents |
|
|
|
|
|
|
Sommario/riassunto |
|
This practice-oriented handbook surveys current knowledge on the prediction and prevention of adverse drug reactions related to off-target activity of small molecule drugs. It is unique in collating the current approaches into a single source, and includes several highly instructive case studies that may be used as guidelines on how to improve drug development projects.With its large section on ADME-related effects, this is key knowledge for every drug developer. |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
2. |
Record Nr. |
UNINA9910557717903321 |
|
|
Autore |
Congalton Russell G |
|
|
Titolo |
Mapping and Monitoring Forest Cover |
|
|
|
|
|
Pubbl/distr/stampa |
|
|
Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 |
|
|
|
|
|
|
|
|
|
Descrizione fisica |
|
1 online resource (144 p.) |
|
|
|
|
|
|
Soggetti |
|
Research and information: general |
|
|
|
|
|
|
Lingua di pubblicazione |
|
|
|
|
|
|
Formato |
Materiale a stampa |
|
|
|
|
|
Livello bibliografico |
Monografia |
|
|
|
|
|
Sommario/riassunto |
|
This book is a compilation of six papers that provide some valuable information about mapping and monitoring forest cover using remotely sensed imagery. Examples include mapping large areas of forest, evaluating forest change over time, combining remotely sensed imagery with ground inventory information, and mapping forest characteristics from very high spatial resolution data. Together, these results demonstrate effective techniques for effectively learning more about our very important forest resources. |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
3. |
Record Nr. |
UNINA9910557709303321 |
|
|
Autore |
Navrátilová Alice |
|
|
Titolo |
Nerovný vývoj světa a rozvojová teorie / Alice Navrátilová |
|
|
|
|
|
Pubbl/distr/stampa |
|
|
Brno [Czech Republic], : Masarykova univerzita nakladatelství, 2020 |
|
|
|
|
|
|
|
ISBN |
|
|
|
|
|
|
|
|
Edizione |
[1st ed.] |
|
|
|
|
|
Descrizione fisica |
|
1 electronic resource (190 p.) |
|
|
|
|
|
|
Soggetti |
|
History |
Human geography |
Political Sciences |
Social development |
Social Theory |
Economic development |
|
|
|
|
|
|
|
|
Lingua di pubblicazione |
|
|
|
|
|
|
Formato |
Materiale a stampa |
|
|
|
|
|
Livello bibliografico |
Collezione |
|
|
|
|
|
Nota di contenuto |
|
Intro -- Obsah -- Úvod -- 1. Kategorie rozvoje -- 1.1. PŘEHLED ROZVOJOVÝCH TERMÍNŮ -- 1.2. POKROK A ROZVOJ -- 1.3. ZÁPADNÍ MODERNITA12 -- 1.4. RŮZNÁ CHÁPÁNÍ ROZVOJE -- 1.4.1 ROZVOJ JAKO CÍLENÉ JEDNÁNÍ (ROZVOJ S VELKÝM R) -- 1.4.2. POLITICKÝ PROJEKT ROZVOJE -- 1.5. ROZVOJOVÁ TEORIE -- 1.6. TRENDY V ROZVOJOVÉ TEORII -- 1.7. KLASIFIKACE ROZVOJOVÉ TEORIE -- 2. Problematika nerovností a metodologie -- 2.1. KONCEPT CHUDOBY -- 2.2. KLASIFIKACE SVĚTOVÉHO SYSTÉMU -- 2.2.1. KLASIFIKACE PODLE PŘÍJMU/PER CAPITA -- 2.2.2. KLASIFIKACE ZALOŽENÁ NA VZORCÍCH OBCHODU -- 2.2.3. KLASIFIKACE ZALOŽENÉ NA INDIKÁTORECH KVALITY ŽIVOTA -- 3. Modernizační škola -- 3.2. HLAVNÍ TEZE A PERIODIZACE MODERNIZAČNÍ ŠKOLY -- 3.3. LINEÁRNÍ MODELY RŮSTU -- 3.4. MODERNIZAČNÍ ŠKOLA A ROLE KULTURY -- 3.5. EXKURS: INSTITUCIONALIZACE ROZVOJOVÝCH STUDIÍ A EXPERTNÍ VĚDĚNÍ -- 3.5.1. ANTROPOLOGIE A INSTITUCIONALIZACE ROZVOJOVÝCH STUDIÍ -- 4. Historická dynamika nerovností a škola závislosti -- 4.1. DEFINICE A PERIODIZACE KOLONIALISMU -- 4.1.1. PŘÍPADOVÁ STUDIE: BARANŮV KOLONIALISMUS V INDII -- 4.2. HLAVNÍ TEZE ŠKOLY |
|
|
|
|
|
|
|
|
|
|
|
ZÁVISLOSTI -- 4.2.1. STRUKTURALISTICKÁ VERZE ŠKOLY ZÁVISLOSTI -- 4.2.2. NEOMARXISTICKÁ VERZE ŠKOLY ZÁVISLOSTI -- 4.3. TEORIE SVĚTOVÉHO SYSTÉMU -- 5. Washingtonský a post-washingtonský konsensus a alternativy k neoliberální doktríně -- 5.1. NEOLIBERALISMUS -- 5.2. PROGRAMY STRUKTURÁLNÍHO PŘIZPŮSOBENÍ -- 5.3. SVĚTOVÁ BANKA -- 5.4. ROZVOJ JAKO ANTIPOLITICKÁ MAŠINÉRIE -- 6. Přístup základních potřeb, lidsko-právní přístup, občanská společnost a alternativní rozvoj -- 6.1. ZAMĚŘENO NA ČLOVĚKA: PŘÍSTUP ZÁKLADNÍCH POTŘEB -- 6.2. ROZVOJOVÉ CÍLE TISÍCILETÍ -- 6.3. LIDSKÁ PRÁVA A LIDSKO-PRÁVNÍ PŘÍSTUPY -- 6.4. SOCIÁLNÍ ZABEZPEČENÍ PRO MARGINALIZOVANÉ -- 7. Alternativní rozvoj, role občanského sektoru a globální občanská společnost -- 7.1. KATEGORIE OBČANSKÉ SPOLEČNOSTI. |
7.2. NEZISKOVÝ SEKTOR V ROZVOJI -- 7.3. PARTICIPATIVNÍ PŘÍSTUPY V ROZVOJI -- 7.4. MOC A PARTICIPATIVNÍ PŘÍSTUPY -- 7.5. ALTERNATIVNÍ ROZVOJ -- 8. Rozvoj a postmoderní obrat -- 8.1. POSTROZVOJ (POSTDEVELOPMENT) -- 8.2. STRUKTURALISMUS A POSTSTRUKTURALISMUS -- 8.3. CHARAKTERISTIKA ORIENTALISMU -- 8.4. HLAVNÍ ARGUMENTY POSTROZVOJE -- 9. Nerovný vývoj světa a globalizace -- 9.2. DEBATY O „GLOBÁLNÍCH TRANSFORMACÍCH" -- 9.2.1. HYPERGLOBALISTÉ -- 9.2.2. SKEPTIKOVÉ -- 9.2.3. TRANSFORMAČNÍ TEZE -- 9.3. PROJEKT NEOLIBERÁLNÍ GLOBALIZACE A ALTERNATIVNÍ NÁHLEDY -- 9.4. GLOBÁLNÍ NEROVNOSTI -- 10. Závěr -- LITERATURA. |
|
|
|
|
|
|
Sommario/riassunto |
|
The book explores contemporary theories of development and their historical trajectories. It provides an overview of the main development paradigms according to the Neederven Pieterse´s classification: modernization school, dependency school, human development, neoliberalism, alternative development and postdevelopment. All perspectives are narrated from critical post-structuralist perspective exploring the knowledge-power nexus and each paradigm is linked to actors and institutions that apply particular approach. Special attention is paid to the globalisation processes that have dramatically reshaped historical and contemporary patterns of uneven development. The textbook is tailored to introductory courses of human geography, development studies, social and political sciences as well as to answer to the interest of the general public. |
|
|
|
|
|
|
|
| |