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Record Nr. |
UNINA9910830578003321 |
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Titolo |
Molecular Approaches to Malaria / / edited by Irwin W. Sherman |
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Pubbl/distr/stampa |
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Washington, District of Columbia : , : John Wiley & Sons, Inc., , 2014 |
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ISBN |
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Descrizione fisica |
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1 online resource (xviii, 542 pages) : illustrations |
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Disciplina |
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Soggetti |
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Malaria - Molecular aspects |
Molecular biology |
Malaria - Treatment |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Nota di contenuto |
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The life of plasmodium: an overview / I.W. Sherman Plasmo DB / D. Roos -- Making a home for plasmodium post-genomics: ultrastructural organization of the blood stages / L. Bannister, G. Margos and J. Hopkins -- Genetic manipulation of plasmodium falciparum / A. Cowman and B. Crabb -- The transcriptome of the malaria parasite, plasmodium falciparum / K. Le Roch and E. Winzeler -- The plasmodium proteome / J. Johnson and J. Yates -- Evolutionary history and population genetics of human malaria parasites / M. Zilversmit and D. Hartl -- Merozoite / J. Barnwell and M. Galinski -- Ookinete / J. Vinetz -- The sporozoite / R. Sinden and K. Matuschewski -- Gametocytes and gametes / P. Alano and O. Billker -- Molecular approaches to malaria: glycolysis in asexual stage parasites / B. Woodrow and S. Krishna -- The mitochondrion / A. Vaidya -- Trafficking and the TVN / K. Haldar [and others] -- The apicoplast / S. Ralph -- Protein kinases regulating plasmoidum proliferation and development / C. Doerig. -- Proteases and hemoglobin degradation / P. Rosenthal -- Plasmodium lipids: metabolism and function / H. Vial and C. Ben Mamoun -- Plasmodium ribosomes and opportunities for drug intervention / T. McCutchan and I. Sharma -- Oxidative stress and antioxidant defence in malaria parasites / K. Becker, S. Koncarevic, and N. Hunt -- New permeation pathways / S. Thomas and S. Egée -- Molecular aspects of antigenic variation in plasmodium falciparum / P. |
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Horrocks [and others] -- Mechanisms of drug action and resistance / A. Uhlemann, Y. Yuthavong and D.A. Fidock -- Human genetic determinants of resistance to malaria / B.P. Kwiatkowski and G. Luoni -- Progress in development of a vaccine to aid malaria control / S. Moorthy and F. Dubovsky -- The anopheles gambiae genome / H. Collins and C.A. Hill -- The transcriptome of human malaria vectors / O. Marinotti and A.A. James. |
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Sommario/riassunto |
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Provides an overview of the rapid and significant developments that have occurred in malaria research, including the 2002 genome sequencing of Plasmodium falciparum and its mosquito vector, Anopheles gambiae. The book opens with an introduction to Plasmodium molecular biology, followed by several chapters on its genetics and evolution. The remaining five sections examine the intricate host-parasite relationship through comprehensive coverage of invasion and gamete formation; growth and metabolism; immune invasion; protection mechanisms; and the malaria vector. |
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