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Record Nr. |
UNINA9910830570303321 |
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Titolo |
Molecular biology in medicinal chemistry [[electronic resource] /] / edited by Th. Dingermann, D. Steinhilber and G. Folkers |
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Pubbl/distr/stampa |
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Weinheim, : Wiley-VCH, 2004 |
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ISBN |
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1-280-52027-2 |
9786610520275 |
3-527-60518-5 |
3-527-60266-6 |
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Descrizione fisica |
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1 online resource (437 p.) |
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Collana |
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Methods and principles in medicinal chemistry ; ; v. 21 |
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Altri autori (Persone) |
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DingermannTheodor |
FolkersGerd |
SteinhilberDieter <1959-> |
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Disciplina |
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Soggetti |
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Chiral drugs |
Genomics |
Molecular biology |
Molecular pharmacology |
Pharmacogenomics |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references and index. |
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Nota di contenuto |
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Molecular Biology in Medicinal Chemistry; Contents; Preface; Foreword; Contributors; Part I Molecular Targets; 1 Cellular Assays in Drug Discovery; 1.1 Introduction; 1.1.1 Positioning Cellular Assays; 1.1.2 Impact on Drug Discovery; 1.1.3 Classification of Cellular Assays; 1.1.4 Progress in Tools and Technologies for Cellular Compound Profiling; 1.2 Membrane Proteins and Fast Cellular Responses; 1.2.1 Receptors; 1.2.1.1 FLIPR Technology for Detection of Intracellular Calcium Release; 1.2.1.2 Competitive Immunoassay for Detection of Intracellular cAMP |
1.2.1.3 Enzyme Fragment Complementation (EFC) Technology1.2.2 Membrane Transport Proteins; 1.2.2.1 Ion Channels; 1.2.2.2 MDR Proteins; 1.3 Gene and Protein Expression Profiling in High-throughput Formats; 1.3.1 Reporter Gene Assays in Lead Finding; 1.3.2 Reporter Gene Assays in Lead Optimization; 1.4 Spatio-temporal Assays and Subpopulation Analysis; 1.4.1 Phosphorylation Stage-specific |
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