Biology of IGF-1 [[electronic resource] ] : its interaction with insulin in health and malignant states / / [edited by Gregory Bock, Jamie Goode]

• Record Nr.: UNINA9910830531903321
• Pubbl/distr/stampa: The Atrium, Southern Gate, Chichester, UK ; ; Hoboken, NJ, : John Wiley & Sons, c2004
• ISBN: 1-280-27251-1; 9786610272518; 0-470-66753-2; 0-470-86997-6; 0-470-86999-2
• Descrizione fisica: 1 online resource (294 p.)
• Collana: Novartis Foundation symposium ; ; 262
• Classificazione: 44.78
• Altri autori (Persone): BockGregory; GoodeJamie
• Disciplina: 612.01575; 612/.015756
• Soggetti: Somatomedin - Physiological effect; Somatomedin - Pathophysiology; Carcinogenesis
• Lingua di pubblicazione: Inglese
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Note generali: Description based upon print version of record.
• Nota di bibliografia: Includes bibliographical references and indexes.
• Nota di contenuto: Circulating IGF-I and its role in cancer: lessons from the IGF-1 gene-deletion (LID) mouse -- Physiology of the IGF system -- Molecular basis of insulin action -- IGF-1 and insulin as growth hormones -- Insulin-like growth factors and neoplasia -- Loss of IGF2 imprinting: mechanisms and consequences -- Insulin and IGF-1 receptor trafficking and signalling -- The mTOR/S6K signalling pathway: the role of the TSC1/2 tumour suppressor complex and the proto-oncogene Rheb -- Structural biology of insulin and IGF-1 receptors -- Genetic blockade of the insulin-like growth factor-I receptor for human malignancy -- IGF-1 and prostate cancer -- IGF-1 and breast cancer -- IGFBPs and cancer -- The IGF receptor as anticancer treatment target -- Nutrition, insulin, IGF-1 metabolism and cancer risk: a summary of epidemiological evidence.
• Sommario/riassunto: An invaluable book containing a series of interdisciplinary discussions ; between clinical and basic scientists. Biology of IGF-1: Its interaction with insulin and health and malignant states focuses on key issues such as:the definition of danger zonesthe development of methods for early recognition of malignant states linked to IGF-1 and/or insulinpossible approaches to preventative interventionthe relevance in this field of research to the development of novel therapeutic approaches to treating certain cancers.